Protein Alignment Tsp2A and TSPAN18

DIOPT Version :10

• Sequence 1: NP_525037.1
• Gene: Tsp2A / 31080
• FlyBaseID: FBgn0024361
• Length: 244
• Species: Drosophila melanogaster
• Sequence 2: XP_005253274.1
• Gene: TSPAN18 / 90139
• HGNCID: 20660
• Length: 258
• Species: Homo sapiens
• Alignment Length: 257
• Identity: 66/257 - (25%)
• Similarity: 106/257 - (41%)
• Gaps: 65/257 - (25%)

  Fly    16 IGCVKYTLFCFNIVAWMISTALFALTVWLRAEP-GFNDWLRILEAQSFYI-GVYVLIGISIVMMA 78
            :.|:||.:|.||...::....|.|:.:|:..:| ||.:   |:.|....: |.|:|:.:..::..
Human    16 LSCMKYLMFVFNFFIFLGGACLLAIGIWVMVDPTGFRE---IVAANPLLLTGAYILLAMGGLLFL 77

  Fly    79 VSFLGCLSALMENTLALFVFVGTQVFGFIAIV---AGSAVLLQFSTINSSLQPLLNVSLRGFVAT 140
            :.||||..|:.||...|..|     |.||.|:   ..||.:|.|....:..:......|     |
Human    78 LGFLGCCGAVRENKCLLLFF-----FLFILIIFLAELSAAILAFIFRENLTREFFTKEL-----T 132

  Fly   141 SEY-----------TYSNYVLTMIQENIGCCGATGPWDY----------LDLRQPLPSSC----- 179
            ..|           |:::.::|     .||||..||.|:          || .:.:|.:|
Human   133 KHYQGNNDTDVFSATWNSVMIT-----FGCCGVNGPEDFKFASVFRLLTLD-SEEVPEACCRREP 191

  Fly   180 --RDTV--------SGNAFF---NGCVDELTWFFEGKTGWIVALAMTLGLLNVICAVMSFVL 228
              ||.|        .|.:.|   .||...:...||  |...:|.|:.:|:|.:....|.|.:
Human   192 QSRDGVLLSREECLLGRSLFLNKQGCYTVILNTFE--TYVYLAGALAIGVLAIELFAMIFAM 251

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp2A	NP_525037.1	Tetraspanin	19..230	CDD:459767	65/254 (26%)
TSPAN18	XP_005253274.1	Tetraspanin	20..255	CDD:459767	65/253 (26%)
		uroplakin_I_like_LEL	115..228	CDD:239409	26/125 (21%)