DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tsp2A and Tspan2

DIOPT Version :9

Sequence 1:	NP_001188523.1	Gene:	Tsp2A / 31080	FlyBaseID:	FBgn0024361	Length:	244	Species:	Drosophila melanogaster
Sequence 2:	NP_072111.1	Gene:	Tspan2 / 64521	RGDID:	620982	Length:	221	Species:	Rattus norvegicus

Alignment Length:	245	Identity:	60/245 - (24%)
Similarity:	100/245 - (40%)	Gaps:	60/245 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 CVKYTLFCFNIVAWMISTALFALTVWLRAEPGFNDWLRILEAQS-----FYIGVYVLIGISIVMM 77
            |:||.|..||::.|:..:|:.|..:|.|    |...::.|.::.     ||:|:|||:|...:||
  Rat    10 CIKYLLLGFNLLFWLAGSAVIAFGLWFR----FGGTIKDLSSEEKSPEYFYVGLYVLVGAGALMM 70

  Fly    78 AVSFLGCLSALMEN--------TLALFVF---VGTQVFGFIAIVAGSAVLLQFSTINSSLQPLLN 131
            ||.|.||..|:.|:        |..|.:|   |.|.||.||.                     .:
  Rat    71 AVGFFGCCGAMRESQCVLGSFFTCLLVIFAAEVTTGVFAFIG---------------------KD 114

  Fly   132 VSLRGFVATSEYTYSNYV---------LTMIQENIGCCGATGPWDYLDLRQPLPSSCRDTVSGNA 187
            |::|...:..|..||:||         |........|||.       :..:.:..:|...:.|:
  Rat   115 VAIRHVQSMYEEAYSDYVRDRGRGNGTLITFHSAFQCCGK-------ESSEQVQPTCPKELPGH- 171

  Fly   188 FFNGCVDELTWFFEGKTGWIVALAMTLGLLNVICAVMSFVLVQAVKKEEE 237
              ..|:|::......|...|..:.:.:..|.:...:.|.||..|::...:
  Rat   172 --KNCIDKIETIISVKLQLIGIVGIGIAGLTIFGMIFSMVLCCAIRNSRD 219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsp2A	NP_001188523.1	Tetraspannin	18..232	CDD:278750	59/238 (25%)
Tsp2A	NP_001188523.1	tetraspanin_LEL	116..204	CDD:239401	15/96 (16%)
Tspan2	NP_072111.1	Tetraspannin	10..214	CDD:278750	59/238 (25%)
Tspan2	NP_072111.1	CD81_like_LEL	110..186	CDD:239404	17/106 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3882
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1205716at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X522
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820