Protein Alignment Tsp2A and PRPH2

DIOPT Version :10

• Sequence 1: NP_525037.1
• Gene: Tsp2A / 31080
• FlyBaseID: FBgn0024361
• Length: 244
• Species: Drosophila melanogaster
• Sequence 2: NP_000313.2
• Gene: PRPH2 / 5961
• HGNCID: 9942
• Length: 346
• Species: Homo sapiens
• Alignment Length: 272
• Identity: 53/272 - (19%)
• Similarity: 90/272 - (33%)
• Gaps: 95/272 - (34%)

  Fly    26 FNIVAWMISTALFALTVWLRAEPGFNDWLR----ILEAQSFYIGVYVLIGISIVMMAVSFLG--- 83
            |:::|.:|   :|:|.::|:.|      ||    ::.....:.....|||:.::....:.|.
Human    26 FSVLAGII---IFSLGLFLKIE------LRKRSDVMNNSESHFVPNSLIGMGVLSCVFNSLAGKI 81

  Fly    84 CLSAL-----------MENTLALFVFVGTQVFGFIAIVAGSAVLLQFSTINSSLQPLLNVSLRGF 137
            |..||           ::..||:.|.....:|    :||....||:.|..|:..|.|.| .::.:
Human    82 CYDALDPAKYARWKPWLKPYLAICVLFNIILF----LVALCCFLLRGSLENTLGQGLKN-GMKYY 141

  Fly   138 --VATSEYTYSNYVLTMIQENIGCCGATGPWD----------YLD------------------LR 172
              ..|....:....:.|:|....|||..|..|          |||                  |.
Human   142 RDTDTPGRCFMKKTIDMLQIEFKCCGNNGFRDWFEIQWISNRYLDFSSKEVKDRIKSNVDGRYLV 206

  Fly   173 QPLPSSC------------------------RDTVSGNAFFNGCVDELTWFFEGKTG-------- 205
            ..:|.||                        ..|...|.:..||...|..::.....
Human   207 DGVPFSCCNPSSPRPCIQYQITNNSAHYSYDHQTEELNLWVRGCRAALLSYYSSLMNSMGVVTLL 271

  Fly   206 -WIVALAMTLGL 216
             |:..:.:|:||
Human   272 IWLFEVTITIGL 283

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp2A	NP_525037.1	Tetraspanin	19..230	CDD:459767	53/272 (19%)
PRPH2	NP_000313.2	Tetraspanin	16..181	CDD:459767	37/168 (22%)
		peripherin_like_LEL	120..262	CDD:239415	27/142 (19%)
		Interaction with MREG. /evidence=ECO:0000250	341..346