DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAAM and FMNL3

DIOPT Version :9

Sequence 1:	NP_001188522.1	Gene:	DAAM / 31075	FlyBaseID:	FBgn0025641	Length:	1463	Species:	Drosophila melanogaster
Sequence 2:	XP_011537270.1	Gene:	FMNL3 / 91010	HGNCID:	23698	Length:	1047	Species:	Homo sapiens

Alignment Length:	1180	Identity:	323/1180 - (27%)
Similarity:	506/1180 - (42%)	Gaps:	275/1180 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 SGNTSSNETP-----LQKHYRHQQKKKMPGFRGRRVWCGCFKDDEPPEICVVEGAFTLQTLTPTQ 348
            ||:.||...|     |.:.|.:::|..:...:.|      |:...||...:.:    ||:...
Human    58 SGDRSSMNLPPDKARLLRQYDNEKKWDLICDQER------FQVKNPPHTYIQK----LQSFLD-- 110

  Fly   349 PMPSVDELDTKFAELVEELDLTAPNKEAMLSLPAQK-KWQ--------------------IYCSR 392
              |||..  .||...|:|  .|...:|..:||.... .|.                    ..||.
Human   111 --PSVTR--KKFRRRVQE--STKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSV 169

  Fly   393 KLPLDAADGPDAAAVTQPPTAEHYIERLKELVVHISLSPEDSPSHELGNRLDGHAAFVDALKTAL 457
            ....:..:..|..|..:..:....||         .|.|..:.|          |.|.::|..:.
Human   170 MFDFEGLESGDDGAFDKLRSWSRSIE---------DLQPPSALS----------APFTNSLARSA 215

  Fly   458 RTSTHSFVLRFVELDGLPALLD--LLLQLDIRVANSPLHTSLIGCIKALMNNSMGRAHVLAHPTA 520
            |.|    |||:..|.|..||.:  |:.|.|      .:|..:: |::|:||...|...|::||.|
Human   216 RQS----VLRYSTLPGRRALKNSRLVSQKD------DVHVCIL-CLRAIMNYQYGFNLVMSHPHA 269

  Fly   521 IDTIARSLAADNIRTKIAALEILGAVCLVPGGHRKVLQAMLHFQVFATERTRFQSIVNDLDRSTY 585
            ::.||.||...|.|||...||:|.|||||.|||..:|.|..:|:....|..||:.::.
Human   270 VNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKELHRFEKLME------- 327

  Fly   586 AYRD---NVNLKTALMSFVNAVLNYGPGQENLEFRLHLRYEFLMLGIQPVIDKLRTHENETLDRH 647
            .:|:   |::...|.|.|:|.|::   ..|::.||:||:|||..||::..:.|.|..|:|.|.
Human   328 YFRNEDSNIDFMVACMQFINIVVH---SVEDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQ-- 387

  Fly   648 LDFFEMVRAEDEKEFARRFKEEHVDTKSAGSMFELLRRKLSHSPAYPHMLSLLQHMLLLPYTGHC 712
                ..::|..:..|......|..:||:.               |...:..|.:|:      .|.
Human   388 ----VQIQAYLDNVFDVGGLLEDAETKNV---------------ALEKVEELEEHV------SHL 427

  Fly   713 TEHWLLIDRVVQQIVLQVEQRPNSDLIVDPDDPEKQLKLAAESPVHDPDVAPLQIDVAKLVRLLV 777
            ||                                   ||             |.::...::|:..
Human   428 TE-----------------------------------KL-------------LDLENENMMRVAE 444

  Fly   778 KEEQLTQARKRADELER--ENFDVQ----SRLAKKEQELDLRMQEKEDLETGLARMRERLEKESA 836
            .|:||.|..|..:.::.  ||...|    .||.|:::|...|....|....||         ||.
Human   445 LEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGL---------ESV 500

  Fly   837 QHSQAVQRAQTAEMRAEDLQHRLISEQQERARLERLVTEGSIPDDQKVAGLTGCNGAVSPPPAPP 901
            . |:|:.|...||:                       :||..|.|..:..           ||||
Human   501 D-SEALARVGPAEL-----------------------SEGMPPSDLDLLA-----------PAPP 530

  Fly   902 MLKAIPPPPPPMAPSMMPPPPPP----CPGAPPPP---PSMAQTMAPAPPKVDLPKKNVPQPTNP 959
            ..:.:|.||||..|  :||||||    ||.|||.|   ||:..|:..:..::..|.|...:
Human   531 PEEVLPLPPPPAPP--LPPPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFR---- 589

  Fly   960 LKSFNWSKLPDAKLQGTVWSELDESKLYNNMELESIDKLFSAYQKNGVSATDGSYEDLRVTGKAA 1024
            |..|||:.|...::.|||:||||:.|:..:::|:..::||.       :...|...||..:....
Human   590 LPVFNWTALKPNQISGTVFSELDDEKILEDLDLDKFEELFK-------TKAQGPALDLICSKNKT 647

  Fly  1025 KQKVLS---VIDGRRAQNCTILLSKLKMSDMEISKAILSMDSNEQLQLDMVEQLLKFTPSAEERA 1086
            .||..|   :::..||:|..|.|.|...|..||.:||.:.|. :.|.:|.||.|::|.|:..|..
Human   648 AQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDL-QTLPVDFVECLMRFLPTEAEVK 711

  Fly  1087 LLDEHSED---IESLARADRFLYEISKIPHYEQRLKSLHYKKRFMLTINDLVPRITSVMEASREV 1148
            ||.::..:   :|.||..|||:...||:....||:..:.:...|...:..|.|::.:::.||..|
Human   712 LLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASV 776

  Fly  1149 ARSRRLRKLLELVLALGNYMNRGARGNASGFRLASLNRLADTKSSAAKGTTLLHYLVQVIERKFK 1213
            ..|::|:::||::||||||||...||...||:|.||:.|.||||:..| .||||::...::.|:.
Human   777 KSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRK-MTLLHFIALTVKEKYP 840

  Fly  1214 DLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEFHRSSGPAQQGDRFLPVMREFHA 1278
            ||.....::..|.:|:.|||..:..|::.|..|:..:.||...|.:|           |:|.|
Human   841 DLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNS-----------VLRNF-- 892

  Fly  1279 QASVRFAELEDKFQDMKT---RFDRAVRLFGEDGSVLQPDEFFGIFDSFLAAFAEARHDNESFRR 1340
             .|....:|:...:|.||   .::..||.|||......|..||.:|..|:.::.||..:||: |:
Human   893 -LSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEA-RK 955

  Fly  1341 RQEE--EEKRAKQEA-ELKKRTIERKNK---TGLMTSVARNLGLKSGSSNGDPDSPAKGGDNKGE 1399
            :|||  .||:..||| :|..:|..::||   ..|:..:.|.        ......|...|.: |.
Human   956 KQEEVMREKQLAQEAKKLDAKTPSQRNKWQQQELIAELRRR--------QAKEHRPVYEGKD-GT 1011

  Fly  1400 FDDLISALRT 1409
            .:|:|:.|::
Human  1012 IEDIITVLKS 1021

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:283920	59/221 (27%)
		Drf_FH3	551..737	CDD:283917	42/188 (22%)
		FliJ	779..>875	CDD:280262	23/101 (23%)
		FH2	950..1328	CDD:280362	123/386 (32%)
FMNL3	XP_011537270.1	Drf_GBD	64..297	CDD:283920	69/280 (25%)
		Drf_FH3	300..497	CDD:283917	60/281 (21%)
		FH2	580..945	CDD:280362	124/391 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54599
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950