Protein Alignment DAAM and BNI1

DIOPT Version :10

• Sequence 1: NP_001188522.1
• Gene: DAAM / 31075
• FlyBaseID: FBgn0025641
• Length: 1463
• Species: Drosophila melanogaster
• Sequence 2: NP_014128.2
• Gene: BNI1 / 855450
• SGDID: S000005215
• Length: 1953
• Species: Saccharomyces cerevisiae
• Alignment Length: 2015
• Identity: 376/2015 - (18%)
• Similarity: 618/2015 - (30%)
• Gaps: 811/2015 - (40%)

  Fly    32 HSANTEILQTSPESTLEKPKA-APSGGASTSVTSLNGSCIA--------INGGIGEGATATASAA 87
            ||.....:.|||.|:....|. |||...||....||.....        :||.: .|....:|..
Yeast    51 HSPVGNEVSTSPASSSSFRKLNAPSRSTSTEARPLNKKSTLNTQNLSQYMNGKL-SGDVPVSSQH 114

  Fly    88 TSTAAGVTKITITSDNGNGNASTSTKAPTTGSSIDGYKNSSLVSITSLNSCSDLSQGSTATLPIS 152
            ..:.:..:|.:.:..| :..||.......||.|   :..|||           |||||.
Yeast   115 ARSHSMQSKYSYSKRN-SSQASNKLTRQHTGQS---HSASSL-----------LSQGSL------ 158

  Fly   153 SNSCSGNNVSRHPLSNNNSGSDTSSNNFQERFDFEHWKGLLSDYNCFHGLYRYWTQCSGRSSSAN 217
                  .|:|:....:.....:..|:.::....||   .::...|.|..|
Yeast   159 ------TNLSKFTTPDGKIYLEMPSDPYEVEVLFE---DIMYKRNIFQSL--------------- 199

  Fly   218 DNGGGSDQQQSQSNHENGLGSEAGSFYTHNILGYTFGYPFGL-KEDLDGS-----GNCNSNCNGS 276
                ..|:|::                   ::||:....:.: |:||...     .|..|:...|
Yeast   200 ----SEDKQEA-------------------LMGYSIEKKWLIVKQDLQNELKKMRANTTSSSTAS 241

  Fly   277 SNTNGLGLRKWLSGNTS----------SNETPLQKHY----RHQQKKKMPG---FRGRRVWCGCF 324
            ..:........|:.|:|          |..:|....|    .|.......|   .:|:::..|..
Yeast   242 RTSMASDHHPILTANSSLSSPKSVLMTSASSPTSTVYSNSLNHSTTLSSVGTSTSKGKKLVSGSL 306

  Fly   325 KDDEPPEICVVEGAFTLQTLTPTQPMPSVDELDTKFAELVEELDLTAPNKEAMLSLPAQKKWQIY 389
            |                       ..||::.:....||          |..:..:||..:
Yeast   307 K-----------------------KQPSLNNIYRGGAE----------NNTSASTLPGDR----- 333

  Fly   390 CSRKLPLDAADGPDAAAVTQPPTAEHYIERLKELVVHISLSPEDSPSHELGNRLDGHAAFVDALK 454
                             ..:||.  ||::|:                  |.::|..     |.:|
Yeast   334 -----------------TNRPPI--HYVQRI------------------LADKLTS-----DEMK 356

  Fly   455 ---TALRTSTHSFVLRFVELDGLPALLDLLLQLDIRVANSPLHT--------SLIGCIKALMNNS 508
               ..|||....:|..|::..|..|:.::|:....:.|.....|        |...|.:.|...|
Yeast   357 DLWVTLRTEQLDWVDAFIDHQGHIAMANVLMNSIYKTAPRENLTKELLEKENSFFKCFRVLSMLS 421

  Fly   509 MGRAHVLAHPTAIDTIARSLAADNIRTKIAALEILGAVCLVP----------------------- 550
            .|......|....||:|..|.:..:.|:..|.||.  ||::.
Yeast   422 QGLYEFSTHRLMTDTVAEGLFSTKLATRKMATEIF--VCMLEKKNKSRFEAVLTSLDKKFRIGQN 484

  Fly   551 -------------------GGHRKVLQAMLHFQVFATERT-----RFQSIVNDLDRSTYAYRDNV 591
                               ..|.|::||.|    ||.|:|     :..|:|...|.......:|.
Yeast   485 LHMIQNFKKMPQYFSHLTLESHLKIIQAWL----FAVEQTLDGRGKMGSLVGASDEFKNGGGENA 545

  Fly   592 NLKTA--LMSFVNAVLNYGPGQENLEFRLHLRYEFLMLGI------------QPVIDKLRTHENE 642
            .|:..  .|.|:|.:.:.   .:|:..|:.||.:....||            ..|||::..::|.
Yeast   546 ILEYCQWTMVFINHLCSC---SDNINQRMLLRTKLENCGILRIMNKIKLLDYDKVIDQIELYDNN 607

  Fly   643 TLDRHLDFFEMVRA--------------------------EDEKEF----------ARRFKEEHV 671
            .||   ||...:.|                          |:||..          :.:..||:.
Yeast   608 KLD---DFNVKLEANNKAFNVDLHDPLSLLKNLWDICKGTENEKLLVSLVQHLFLSSSKLIEENQ 669

  Fly   672 DTKSAGSMFELL------------------------------------RRKLSHSPA-------- 692
            ::.......:|:                                    ||.:..|.|
Yeast   670 NSSKLTKQLKLMDSLVTNVSVASTSDEETNMNMAIQRLYDAMQTDEVARRAILESRALTKKLEEI 734

  Fly   693 ------YPHMLSLLQHMLLLPYTGHCTEHWLLI---DRVVQQIVLQVEQ---------------- 732
                  ....||..:|.|:........|...::   .||:||:..::|:
Yeast   735 QAERDSLSEKLSKAEHGLVGQLEDELHERDRILAKNQRVMQQLEAELEELKKKHLLEKHQQEVEL 799

  Fly   733 ---------RP-------------NSDL-----------IVD---------PDD---------PE 746
                     ||             ||.|           :.|         .||         |.
Yeast   800 RKMLTILNSRPEESFNKNEGTRGMNSSLNSSEKANIQKVLQDGLSRAKKDYKDDSKKFGMTLQPN 864

  Fly   747 KQLKL--------------------------AAESPVH--------------DPDVAPLQIDVAK 771
            |:||:                          ..|.|:|              .|.|.|.:.||.|
Yeast   865 KRLKMLRMQMENIENEARQLEMTNFAEFEKDRLEPPIHIKKPKVKKMKNKDRKPLVKPQEADVNK 929

  Fly   772 L---------------------VRLLVKE---EQLTQARKRADELERE------NFDV------- 799
            |                     |...|.|   |:.:.|.||..|||.:      :|:|
Yeast   930 LNDLRRALAEIQMESNDISKFNVEERVNELFNEKKSLALKRLKELETKYKGFGIDFNVDEIMDSP 994

  Fly   800 -----------------------QSRLAK----KEQELDLRMQEKEDLE---------------- 821
                                   |.:|.:    .:|.||::.|.:.:::
Yeast   995 KKNTGDVETEEDANYASLDPKTYQKKLDEINRITDQLLDIQTQTEHEIQVEEDGESDLSSSSSDD 1059

  Fly   822 ---------------------------------------------------------TGLARMRE 829
                                                                     :|:..:..
Yeast  1060 ESEEIYQDASPTQELRSEHSELSSGSGPGSFLDALSQKYGTGQNVTASAAFGENNNGSGIGPLHS 1124

  Fly   830 RLEK-----------ESAQH----SQAVQRAQTAEMRA-EDLQHRLISEQQ-------------- 864
            ::||           .||.:    :|.|.:.:..|... |.|..:.:.|..
Yeast  1125 KVEKTFMNRLRKSTVSSAPYLEELTQKVNKVEPYEQNEDEGLDKKSLPENSTASAASAFDKAEKD 1189

  Fly   865 -----ERARLERLVT--EGSIPDDQKVAGLTGCNGA---------VSPPPAPPMLKAIPPPPPPM 913
                 |..:..|:|.  |....|...|:.|...:||         :|..|.||     ||||||:
Yeast  1190 MRQHVENGKQGRVVNHEEDKTADFSAVSKLNNTDGAEDLSTQSSVLSSQPPPP-----PPPPPPV 1249

  Fly   914 -----------------------------APSMMPPPPPPCPGA---------PPPPP------- 933
                                         ||...||||||.|.|         |||||
Yeast  1250 PAKLFGESLEKEKKSEDDTVKQETTGDSPAPPPPPPPPPPPPMALFGKPKGETPPPPPLPSVLSS 1314

  Fly   934 SMAQTMAPAPPKVD------------LPK-----KNVPQPTNPLKSFNWSKL--PDAKLQGTVWS 979
            |....:.||||.:.            ||:     :..|:|...||..:|.||  .|..:.||..:
Yeast  1315 STDGVIPPAPPMMPASQIKSAVTSPLLPQSPSLFEKYPRPHKKLKQLHWEKLDCTDNSIWGTGKA 1379

  Fly   980 ELDESKLYNNMELESIDKLFSAYQKNGVSATDGSYEDLRVTGKAAKQKVLSVIDGRRAQNCTI-- 1042
            |.....||....|..::|.|:|.:...:::.  ..|||        ||: :.:....:|...|
Yeast  1380 EKFADDLYEKGVLADLEKAFAAREIKSLASK--RKEDL--------QKI-TFLSRDISQQFGINL 1433

  Fly  1043 -LLSKLKMSDMEISKAILSMDSNEQLQLDMVEQLLK-------------FTPSAEE----RALLD 1089
             :.|.|.::|  :.|.||:.|.:......:||.|.|             :.|.:.:    |.|.|
Yeast  1434 HMYSSLSVAD--LVKKILNCDRDFLQTPSVVEFLSKSEIIEVSVNLARNYAPYSTDWEGVRNLED 1496

  Fly  1090 EH--SEDIESLARADRFLYE--ISKIPHYEQRLKSLHYKKRFMLTINDLVPRITSVMEASREVAR 1150
            ..  .:|...|.|||:...:  ::...::..|:::|.....:....|:|:.::..|.:|...:..
Yeast  1497 AKPPEKDPNDLQRADQIYLQLMVNLESYWGSRMRALTVVTSYEREYNELLAKLRKVDKAVSALQE 1561

  Fly  1151 SRRLRKLLELVLALGNYMNRGARGNASGFRLASLNRLA---DTKSSAAKGTTLLHYLVQVIERKF 1212
            |..||.:..::||:||:||..:: .|.||:|::|.||.   ||.:|    .|.|:|:.:::...:
Yeast  1562 SDNLRNVFNVILAVGNFMNDTSK-QAQGFKLSTLQRLTFIKDTTNS----MTFLNYVEKIVRLNY 1621

  Fly  1213 KDLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEFHRSSGPAQQGDRF-------- 1269
            ........::..|.:..|||:.::..|.:.....:.:|.|.:|.    |......:|
Yeast  1622 PSFNDFLSELEPVLDVVKVSIEQLVNDCKDFSQSIVNVERSVEI----GNLSDSSKFHPLDKVLI 1682

  Fly  1270 --LPVMREFHAQASVRFAELEDKFQDMKTRFDRAVRLFGED-GSVLQPDEFFGIFDSFLAAFAEA 1331
              |||:.|...:..:    |||:.:.....|:..:..:||| |.......||..|..|:..:.:|
Yeast  1683 KTLPVLPEARKKGDL----LEDEVKLTIMEFESLMHTYGEDSGDKFAKISFFKKFADFINEYKKA 1743

  Fly  1332 RHDNESFRRRQ----------EEEEKRAKQEAELKKRTIERKNKTGLMTSVARNLGLKSGSSNGD 1386
            :..|.:....:          ||::||| ||.|.:|   |..|               |.||.|:
Yeast  1744 QAQNLAAEEEERLYIKHKKIVEEQQKRA-QEKEKQK---ENSN---------------SPSSEGN 1789

  Fly  1387 PDSPAKGGDNKGEFDDLISALRTGDVFGEDMAKFKRSRKARVLNGGGSSTGHTSPPRHGSLQREE 1451
            .:..|:  |.:...|.|:..|:.......|.:.   :||..::.....|....:|.....|..||
Yeast  1790 EEDEAE--DRRAVMDKLLEQLKNAGPAKSDPSS---ARKRALVRKKYLSEKDNAPQLLNDLDTEE 1849

  Fly  1452  1451
            Yeast  1850  1849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:461886	41/209 (20%)
		Drf_FH3	551..737	CDD:461885	55/331 (17%)
		Smc	<765..>875	CDD:440809	36/283 (13%)
		FH2	950..1328	CDD:396655	98/422 (23%)
BNI1	NP_014128.2	Drf_GBD	178..458	CDD:461886	66/402 (16%)
		Drf_FH3	511..707	CDD:461885	36/205 (18%)
		PTZ00491	<690..801	CDD:240439	14/110 (13%)
		FH2	1348..1741	CDD:396655	98/418 (23%)
		PTZ00121	<1739..1841	CDD:173412	27/125 (22%)