DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAAM and FHDC1

DIOPT Version :9

Sequence 1:	NP_001188522.1	Gene:	DAAM / 31075	FlyBaseID:	FBgn0025641	Length:	1463	Species:	Drosophila melanogaster
Sequence 2:	NP_001358045.1	Gene:	FHDC1 / 85462	HGNCID:	29363	Length:	1143	Species:	Homo sapiens

Alignment Length:	659	Identity:	177/659 - (26%)
Similarity:	290/659 - (44%)	Gaps:	123/659 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   877 SIPDDQKVAGLTGCNGAV---SPPPAPPMLKAIPPPPPPMAP-----------SMMPPPPPPCPG 927
            |:..|::...:....|.:   :||||||.    ||||||.:|           |..||||||.||
Human     8 SLVSDKENGNIATAPGFMIGQTPPPAPPP----PPPPPPPSPPCSCSREECPSSPPPPPPPPLPG 68

  Fly   928 ---APPPPPSMAQTMAPAPPKVDLPKKNVPQPTNPLKSFNWSKLPDAKLQG--TVWSELDESKLY 987
               .|||||.:       ||...:...:.......::||.|..:|:.:::|  .:|:.....:.:
Human    69 EPPIPPPPPGL-------PPTTHMNGYSHLGKKKRMRSFFWKTIPEEQVRGKTNIWTLAARQEHH 126

  Fly   988 NNMELESIDKLFSAYQKNGVSATDGSYEDLRVTGKAAKQKVLSVIDGRRAQNCTILLSKLKMSDM 1052
            ..::.::|::||...:....|:.......|..:.:.|:::: :::|.:|:.|..|.|.:.|.|..
Human   127 YQIDTKTIEELFGQQEDTTKSSLPRRGRTLNSSFREAREEI-TILDAKRSMNIGIFLKQFKKSPR 190

  Fly  1053 EISKAILSMDSNEQLQLDMVEQLLKFTPSAEERALLDEHSEDIESLARADRFLYEISKIPHYEQR 1117
            .|.:.| ....:|....:.:.:.|||.|.:||...|...|.|:..|:.||.|||.:.::|:|..|
Human   191 SIVEDI-HQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLADSFLYGLIQVPNYSLR 254

  Fly  1118 LKSLHYKKRFMLTINDLVPRITSVMEASREVARSRRLRKLLELVLALGNYMNRGA-RGNASGFRL 1181
            ::::..||.|:.:.:.|...||.:..|.:|:.....|..:|.|||..||.||.|. .|||.||:|
Human   255 IEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIMNAGGYAGNAVGFKL 319

  Fly  1182 ASLNRLADTKSSAAKGTTLLHYLVQVIERKFKDLLKLEDDIPHVREASKVSLGEMDKDIQMLRTG 1246
            :||.:|||||:: ..|..|||::.|..::|...||...:.:.||::.:::||...:.::.:|...
Human   320 SSLLKLADTKAN-KPGMNLLHFVAQEAQKKDTILLNFSEKLHHVQKTARLSLENTEAELHLLFVR 383

  Fly  1247 LADVAREIEFHRSSGPAQQGDRFLPVMREFHAQASVRFAELEDKFQDMKTRFDRAVRLFGEDGSV 1311
            ...:...|:  |.....||       |.:|...|..:..|||...|:::......:..|.||...
Human   384 TKSLKENIQ--RDGELCQQ-------MEDFLQFAIEKLRELECWKQELQDEAYTLIDFFCEDKKT 439

  Fly  1312 LQPDEFFGIFDSFLAAFAEA---RHDNES-----FRRRQEEEEKR-------------------- 1348
            ::.||.|.||..|...|.:|   .||.|:     .:|.:|:|:|:
Human   440 MKLDECFQIFRDFCTKFNKAVKDNHDREAQELRQLQRLKEQEQKQRSWATGELGAFGRSSSENDV 504

  Fly  1349 ---AKQEAE-----LKKRTIE-----------RKNKTGLMTSVARNLGLKSGSSNGDPDSPAKGG 1394
               .|:.||     |..|.|.           |:::..|..|..|.|.....||.|.|:.|.|
Human   505 ELLTKKGAEGLLPFLHPRPISPSSPSYRPPNTRRSRLSLGPSADRELLTFLESSTGSPEEPNK-- 567

  Fly  1395 DNKGEFDDL-----------ISALRTGDVFGEDMAKFKRSRKARVLNGG-------GSSTGH--- 1438
                 |..|           |:.|...:|..:| :.|....:|   :||       .|:..|
Human   568 -----FHSLPRSSPRQARPTIACLEPAEVRHQD-SSFAHKPQA---SGGQEEAPNPPSAQAHQLA 623

  Fly  1439 -TSPPRHGS 1446
             ..|..|.|
Human   624 AAQPENHAS 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:283920
		Drf_FH3	551..737	CDD:283917
		FliJ	779..>875	CDD:280262
		FH2	950..1328	CDD:280362	104/380 (27%)
FHDC1	NP_001358045.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..89		30/83 (36%)
		FH2	93..457	CDD:366959	104/375 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	517..638		29/127 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	706..1143
		PHA03307	730..>1136	CDD:223039
		MTBD, microtubule-binding domain. /evidence=ECO:0000269\|PubMed:18815276	960..1086
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1922
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820