DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAAM and FH8

DIOPT Version :9

Sequence 1:	NP_001188522.1	Gene:	DAAM / 31075	FlyBaseID:	FBgn0025641	Length:	1463	Species:	Drosophila melanogaster
Sequence 2:	NP_177171.1	Gene:	FH8 / 843350	AraportID:	AT1G70140	Length:	760	Species:	Arabidopsis thaliana

Alignment Length:	574	Identity:	144/574 - (25%)
Similarity:	239/574 - (41%)	Gaps:	132/574 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   855 LQHRLISEQQERA-RLERLVTEGSIPDDQKV------------------AGLTGCNGAV------ 894
            |..|.:..|:||: ...:.:..|...|:::|                  .|.:..:.:|
plant   161 LYWRKLQSQRERSGSFRKQIVTGEEEDEKEVIYYKNKKKTEPVTEIPLLRGRSSTSHSVIHNEDH 225

  Fly   895 SPPPAPPMLKAIPPPPPP------MAPSMMPPPPPP-----CPGAPPPPP--------SMAQTMA 940
            .|||.....:..||||||      .||:  |.||||     .|..|||||        |.|....
plant   226 QPPPQVKQSEPTPPPPPPSIAVKQSAPT--PSPPPPIKKGSSPSPPPPPPVKKVGALSSSASKPP 288

  Fly   941 PAPPKVDLPKKNVPQPTNPLKSFNWSKL-PDAKLQGTVWSELDESKLYNNMELESIDKLFSAYQK 1004
            |||.:.....:...|.  .||..:|.|: ||:. ...||.::|....  :.:.:.::.|| .|..
plant   289 PAPVRGASGGETSKQV--KLKPLHWDKVNPDSD-HSMVWDKIDRGSF--SFDGDLMEALF-GYVA 347

  Fly  1005 NGVSATDGSYEDLRVTGKAAKQKVLSVIDGRRAQNCTILLSKLKMSDMEISKAILSMDSNEQLQL 1069
            .|..:.:...|      |..|...:.::|.|::||..|:|..|.|:..|:.::::  :.|:.:.
plant   348 VGKKSPEQGDE------KNPKSTQIFILDPRKSQNTAIVLKSLGMTREELVESLI--EGNDFVP- 403

  Fly  1070 DMVEQLLKFTPSAEERALLDEHSEDIESLARADRFLYEISK-IPHYEQRLKSLHYKKRFMLTIND 1133
            |.:|:|.:..|:.||::.:.|...|...||.|:.||:.:.| :|....||.:..::..:...:..
plant   404 DTLERLARIAPTKEEQSAILEFDGDTAKLADAETFLFHLLKSVPTAFTRLNAFLFRANYYPEMAH 468

  Fly  1134 LVPRITSVMEASREVARSRRL-RKLLELVLALGNYMNRG-ARGNASGFRLASLNRLADTKSSAAK 1196
            ....:.::..|.:|: |||.| .||||.:|..||.||.| |||||..|.|.:|.:|:|.||...|
plant   469 HSKCLQTLDLACKEL-RSRGLFVKLLEAILKAGNRMNAGTARGNAQAFNLTALLKLSDVKSVDGK 532

  Fly  1197 GTTLLHYLVQVI-------------------------------------ERKFKDLLK------- 1217
             |:||:::|:.:                                     |.:.|:.||
plant   533 -TSLLNFVVEEVVRSEGKRCVMNRRSHSLTRSGSSNYNGGNSSLQVMSKEEQEKEYLKLGLPVVG 596

  Fly  1218 -LEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEFHRSSGPAQQGD--RFLPVMREF--H 1277
             |..:..:|::|:.|....:......|.....|....|      |..:.|:  ||:..|..|  .
plant   597 GLSSEFSNVKKAACVDYETVVATCSALAVRAKDAKTVI------GECEDGEGGRFVKTMMTFLDS 655

  Fly  1278 AQASVRFAELEDK--FQDMKTRFDRAVRLFGEDGSVLQ---PDEFFGIFDSFLA 1326
            .:..|:.|:.|::  .:.:|...|     :.:.|:|.:   |...|.|...|||
plant   656 VEEEVKIAKGEERKVMELVKRTTD-----YYQAGAVTKGKNPLHLFVIVRDFLA 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:283920
		Drf_FH3	551..737	CDD:283917
		FliJ	779..>875	CDD:280262	5/20 (25%)
		FH2	950..1328	CDD:280362	107/435 (25%)
FH8	NP_177171.1	FH2	297..714	CDD:214697	107/436 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1922
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	116	1.000	Inparanoid score	I2015
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.870