DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAAM and AFH14

DIOPT Version :9

Sequence 1:	NP_001188522.1	Gene:	DAAM / 31075	FlyBaseID:	FBgn0025641	Length:	1463	Species:	Drosophila melanogaster
Sequence 2:	NP_001321171.1	Gene:	AFH14 / 840068	AraportID:	AT1G31810	Length:	1230	Species:	Arabidopsis thaliana

Alignment Length:	594	Identity:	171/594 - (28%)
Similarity:	274/594 - (46%)	Gaps:	120/594 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   886 GLTGCNGAVSPPPAP--------PMLKAIPPPPPPM-----------APSMMPPPPPPCPGA--- 928
            |.||......|||.|        |..|..||||||.           .||..||||||.|.|
plant   651 GSTGNKRQAQPPPPPPPPPPTRIPAAKCAPPPPPPPPTSHSGSIRVGPPSTPPPPPPPPPKANIS 715

  Fly   929 ----------------------PPPPPSMAQTMAPAPP---KVDLPK------------------ 950
                                  |||||.:::|.||.||   |..:|.
plant   716 NAPKPPAPPPLPPSSTRLGAPPPPPPPPLSKTPAPPPPPLSKTPVPPPPPGLGRGTSSGPPPLGA 780

  Fly   951 --KNVPQPTNP---------------------------LKSFNWSKLPDAKLQGTVWSELDESKL 986
              .|.|.|..|                           ||..:|||:..| .:|::|:  |..|.
plant   781 KGSNAPPPPPPAGRGRASLGLGRGRGVSVPTAAPKKTALKPLHWSKVTRA-AKGSLWA--DTQKQ 842

  Fly   987 YN-----NMELESIDKLFSAYQKNGVSATDGSYEDLRVTGKAAKQKVLSVIDGRRAQNCTILLSK 1046
            .|     .:::..::.||||     ||.|.......|.....:|.:.:.::|.|||.||.|:|:|
plant   843 ENQPRAPEIDISELESLFSA-----VSDTTAKKSTGRRGSSISKPEKVQLVDLRRANNCEIMLTK 902

  Fly  1047 LKMSDMEISKAILSMDSNEQLQLDMVEQLLKFTPSAEERALLDEHSEDIESLARADRFLYEISKI 1111
            :|:...::..|:|::|| ..|.:|.||.|:||.|:.||..||..::.|.|.|.:.::|..|:.|:
plant   903 IKIPLPDMLSAVLALDS-LALDIDQVENLIKFCPTKEEMELLRNYTGDKEMLGKCEQFFMELMKV 966

  Fly  1112 PHYEQRLKSLHYKKRFMLTINDLVPRITSVMEASREVARSRRLRKLLELVLALGNYMNRG-ARGN 1175
            |..|.:|:...:|..|...:.:|...:.::..|::||..|.:||::::.:|.|||.:|:| |||:
plant   967 PRIEAKLRVFGFKITFASQVEELKSCLNTINAATKEVKESAKLRQIMQTILTLGNALNQGTARGS 1031

  Fly  1176 ASGFRLASLNRLADTKSSAAKGTTLLHYLVQVIERKFKDLLKLEDDIPHVREASKVSLGEMDKDI 1240
            |.||:|.||.:|:||::...| .||:|||.:::..|..:||...:|:.|:..|||:.|..:.:::
plant  1032 AVGFKLDSLLKLSDTRARNNK-MTLMHYLCKLVGEKMPELLDFANDLVHLEAASKIELKTLAEEM 1095

  Fly  1241 QMLRTGLADVAREIEFHRSSGPAQQGDRFLPVMREFHAQASVRFAELEDKFQDMKTRFDRAVRLF 1305
            |....||..|.:|:....:.|....|  |..|::||...|......|...:.::....|.....|
plant  1096 QAATKGLEKVEQELMASENDGAISLG--FRKVLKEFLDMADEEVKTLASLYSEVGRNADSLSHYF 1158

  Fly  1306 GEDGSVLQPDEFFGIFDSFLAAFAEARHDNESFRRRQEEEEKRAKQEAELKKRTIERK----NKT 1366
            |||.:....::...|...|:..|.::|.:||    :|.|.||:..::..:|:::..:|    |..
plant  1159 GEDPARCPFEQVTKILTLFMKTFIKSREENE----KQAEAEKKKLEKEAIKEKSATKKDGVDNDN 1219

  Fly  1367 GLMTSVARN 1375
            .|:..:.|:
plant  1220 DLIQQIHRH 1228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:283920
		Drf_FH3	551..737	CDD:283917
		FliJ	779..>875	CDD:280262
		FH2	950..1328	CDD:280362	121/430 (28%)
AFH14	NP_001321171.1	PTEN_C2	198..338	CDD:287393
AFH14	NP_001321171.1	FH2	814..1181	CDD:280362	117/378 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	185	1.000	Domainoid score	I993
eggNOG	1	0.900	-	-		E1_KOG1922
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	116	1.000	Inparanoid score	I2015
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	1	1.000	-	-		otm2452
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.870