DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAAM and FH4

DIOPT Version :9

Sequence 1:	NP_001188522.1	Gene:	DAAM / 31075	FlyBaseID:	FBgn0025641	Length:	1463	Species:	Drosophila melanogaster
Sequence 2:	NP_001319073.1	Gene:	FH4 / 839028	AraportID:	AT1G24150	Length:	763	Species:	Arabidopsis thaliana

Alignment Length:	565	Identity:	149/565 - (26%)
Similarity:	243/565 - (43%)	Gaps:	111/565 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   894 VSPPPAPPMLKAIPPPPP--PMAPSMMPPPPPPCP------GAPPPPPSMAQTMAPAPPKVDLPK 950
            |.|.|.||     |||||  |:..|..|||||| |      .:|||||.:.:|.|.:.   ...|
plant   237 VKPDPTPP-----PPPPPPIPVKQSATPPPPPP-PKLKNNGPSPPPPPPLKKTAALSS---SASK 292

  Fly   951 KNVPQPTN-----------PLKSFNWSKL-PDAKLQGTVWSELDESKLYNNMELESIDKLFSAYQ 1003
            |..|.|..           .||..:|.|: ||:. ...||.::|....  :.:.:.::.||....
plant   293 KPPPAPRGSSSGESSNGQVKLKPLHWDKVNPDSD-HSMVWDKIDRGSF--SFDGDLMEALFGYVA 354

  Fly  1004 KNGVSATDGSYEDLRVTGKAAKQKVLSVIDGRRAQNCTILLSKLKMSDMEISKAILSMDSNEQLQ 1068
            ....|..||.  |.:.:..:..|  :.::|.|::||..|:|..|.|:..|:.::::   ......
plant   355 VGKKSPDDGG--DKKPSSASPAQ--IFILDPRKSQNTAIVLKSLGMTRDELVESLM---EGHDFH 412

  Fly  1069 LDMVEQLLKFTPSAEERALLDEHSEDIESLARADRFLYEISK-IPHYEQRLKSLHYKKRFMLTIN 1132
            .|.:|:|.:..|:.||::.:.:...|.:.||.|:.||:.:.| :|....||.:|.::..:...|:
plant   413 PDTLERLSRIAPTKEEQSAILQFDGDTKMLADAESFLFHLLKAVPCAFTRLNALLFRANYYPEIS 477

  Fly  1133 DLVPRITSVMEASREVARSRRL-RKLLELVLALGNYMNRG-ARGNASGFRLASLNRLADTKSSAA 1195
            :....:.::..|..|: |||.| .||||.:|..||.||.| || :|..|.|.:|.:|:|.||...
plant   478 NHNKNLQTLDLACTEL-RSRGLFVKLLEAILKSGNRMNAGTARXDAQAFNLTALLKLSDVKSVDG 541

  Fly  1196 KGTTLLHYLVQVI--------------------------------ERKFKDLLK--------LED 1220
            | ||||:::|:.:                                |.:.|:.|:        |..
plant   542 K-TTLLNFVVEEVVRSEGKRCVLNRRTNRSFSRSSSSSISEVISKEEQEKEYLRLGLPVVGGLSS 605

  Fly  1221 DIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEFHRSSGPAQQGDRFLPVMREF--HAQASVR 1283
            :..:|::|:.|....:......|.:...|..|.:.  :|.|..::|.||:..|.||  ..:..|:
plant   606 EFTNVKKAAAVDYDTVAATCLALTSRAKDARRVLA--QSEGDNKEGVRFVKKMNEFLDSVEEEVK 668

  Fly  1284 FAELEDK----FQDMKTRFDRAVRLFGEDGSVLQPDEFFGIFDSFLAAFAEARHDN---ESFRRR 1341
            .|:.|:|    .....|.:.:|..:.|::     |...|.|...|||..     |.   |..|..
plant   669 LAKEEEKKVLELVKRTTEYYQAGAVKGKN-----PLHLFVIVRDFLAMV-----DKVCVEIARNL 723

  Fly  1342 QEEEEKRAKQEAELKKRTIERKNKTGLMTSVARNLGLKSGSSNGD 1386
            |......:.|:....|..:...|   .|:..:|:   .||.|:.|
plant   724 QRRSSMGSTQQRNAVKFPVLPPN---FMSDRSRS---DSGGSDSD 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:283920
		Drf_FH3	551..737	CDD:283917
		FliJ	779..>875	CDD:280262
		FH2	950..1328	CDD:280362	110/438 (25%)
FH4	NP_001319073.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1922
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	116	1.000	Inparanoid score	I2015
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.860