DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAAM and FH19

DIOPT Version :9

Sequence 1:	NP_001188522.1	Gene:	DAAM / 31075	FlyBaseID:	FBgn0025641	Length:	1463	Species:	Drosophila melanogaster
Sequence 2:	NP_196395.1	Gene:	FH19 / 830671	AraportID:	AT5G07780	Length:	464	Species:	Arabidopsis thaliana

Alignment Length:	491	Identity:	146/491 - (29%)
Similarity:	239/491 - (48%)	Gaps:	51/491 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   887 LTGCNGAVS----PPPAPPMLK---AIPPPPPPMAPSMMPPPPPPCP----GAPPPPPSMAQTMA 940
            |...:||.|    |||.||:::   .:||||||.......|||||.|    .||||||
plant     3 LVDISGAYSLVPLPPPPPPLMRRRAPLPPPPPPPLMRRRAPPPPPPPLMRRRAPPPPP------- 60

  Fly   941 PAPPKVDLPKKNVPQPTNPLKSFNWSKLPDAKLQGTVWSELDESKLYNNMELESIDKLFSAYQKN 1005
              ||.:..|....|:....||..:|.|...| |.|::|.||...:...::|.|.|
plant    61 --PPPLPRPCSRPPKTKCSLKPLHWVKKTRA-LPGSLWDELQRRQECRDIEDEQI---------- 112

  Fly  1006 GVSATDGSYEDLR-VTGKAAKQK------VLSVIDGRRAQNCTILLSKLKMSDMEISKAILSMDS 1063
             :.|.:.|..::. :....||.|      .:.:||.|||.|..|.|..|.:...::..|.::||.
plant   113 -LCAIELSVSEIETIFSLGAKPKPKPEPEKVPLIDLRRATNTEIRLMLLNIRLPDMIAAAMAMDE 176

  Fly  1064 NEQLQLDMVEQLLKFTPSAEERALLDEHSEDIESLARADRFLYEISKIPHYEQRLKSLHYKKRFM 1128
            :.....|.:|.|:...|:.|:...|..::.|..:..:..::|.|:.|:|..|.:|:...:|.:|.
plant   177 SRLDDFDQIENLINLFPTKEDMKFLLTYTGDKGNCEQLFQYLQEVVKVPRVESKLRVFSFKIQFG 241

  Fly  1129 LTINDLVPRITSVMEASREVARSRRLRKLLELVLALGNYMNRG-ARGNASGFRLASLNRLADTKS 1192
            ..|..|...:.:|..|..|:..|::|:.::|.:|.|||.:|:| .||.|.||||.||..|::|::
plant   242 TQITKLTKGLNAVNSACEEIRTSQKLKDIMENILCLGNILNQGTGRGRAVGFRLDSLLILSETRA 306

  Fly  1193 SAAKGTTLLHYLVQVIERKFKDLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEFH 1257
            ..:| .||:|||.:|:..|..|||....|:..:..|||:.|..:.::||.:..||..:.:|:...
plant   307 DNSK-MTLMHYLCKVLASKASDLLDFHKDLESLESASKIQLKSLAEEIQAITKGLEKLKQELTAS 370

  Fly  1258 RSSGPAQQGDRFLPVMREFHAQASVRFAELEDKFQDMKTRFDRAVRLFGEDGSVLQP-DEFFGIF 1321
            .:.||..|  .|..:::||.:.|..:.|.:...:...:...:.....||..    .| ::.....
plant   371 ETDGPVSQ--VFRKLLKEFISNAETQVATVMALYYPARGNAEALAHYFGYH----YPFEQVTATL 429

  Fly  1322 DSFLAAFAEARHDNESFRRRQEEEEKRAKQEAELKK 1357
            .||:..|.:|..:|.   ::.|.|:|:|.:|||::|
plant   430 LSFIRLFKKAHEENV---KQAELEKKKAAKEAEMEK 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:283920
		Drf_FH3	551..737	CDD:283917
		FliJ	779..>875	CDD:280262
		FH2	950..1328	CDD:280362	105/386 (27%)
FH19	NP_196395.1	FH2	68..437	CDD:396655	105/387 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	185	1.000	Domainoid score	I993
eggNOG	1	0.900	-	-		E1_KOG1922
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	1	1.000	-	-		otm2452
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820