DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAAM and DIAPH3

DIOPT Version :9

Sequence 1:	NP_001188522.1	Gene:	DAAM / 31075	FlyBaseID:	FBgn0025641	Length:	1463	Species:	Drosophila melanogaster
Sequence 2:	NP_001035982.1	Gene:	DIAPH3 / 81624	HGNCID:	15480	Length:	1193	Species:	Homo sapiens

Alignment Length:	1204	Identity:	323/1204 - (26%)
Similarity:	536/1204 - (44%)	Gaps:	202/1204 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   290 GNTSSNETPLQKHYRHQQKKKMPGFRGRRVWCGCFKDDEPPEICVVEGAFTLQTLTPTQPM---- 350
            |:.:....|.....|..::.|||..:|.:........:||.|   ....|.|...|.|..|
Human    14 GSAAGTPYPSSASLRGCRESKMPRRKGPQHPPPPSGPEEPGE---KRPKFHLNIRTLTDDMLDKF 75

  Fly   351 ------------PSVDELDTKFAELVEELDLTAPNKEAMLSL--PAQKKWQIYCSRKLPLDAADG 401
                        |.:..|.|.||    ..|.:|...|.|.:.  |..:...:....|:..|....
Human    76 ASIRIPGSKKERPPLPNLKTAFA----SSDCSAAPLEMMENFPKPLSENELLELFEKMMEDMNLN 136

  Fly   402 PDAAAVTQPPTAEHYIERLKELVVH----------ISLSPEDSPS---HEL--GNRLDGHAAFVD 451
            .|..|    |..|......||:|:.          :..|.:.||.   |||  |:..:.....::
Human   137 EDKKA----PLREKDFSIKKEMVMQYINTASKTGSLKRSRQISPQEFIHELKMGSADERLVTCLE 197

  Fly   452 ALKTALRTSTHSFVLRFVELDGLPALLDLLLQL-----DIRVANSPLHTSLIGCIKALMNNSMGR 511
            :|:.:|.::..|:|..|.. :||..|||:|.:|     ..:|.....| .:|.|:|||||...|.
Human   198 SLRVSLTSNPVSWVESFGH-EGLGLLLDILEKLISGKIQEKVVKKNQH-KVIQCLKALMNTQYGL 260

  Fly   512 AHVLAHPTAIDTIARSLAAD----NIRTKIAALEILGAVCLVPGGHRKVLQAMLHFQVFATER-- 570
            ..:::...::..:|:  |.|    |:.|.:  :::|.|||:|  |...:|:.:|.....|.|.
Human   261 ERIMSEERSLSLLAK--AVDPRHPNMMTDV--VKLLSAVCIV--GEESILEEVLEALTSAGEEKK 319

  Fly   571 -TRFQSIVNDLDRSTYAYRDNVNLKTALMSFVNAVLNYGPGQENLEFRLHLRYEFLMLGIQPVID 634
             .||..||..|      ..::|.|:.|.|..:||::.   ..::|:||||:|.||:..|::.::.
Human   320 IDRFFCIVEGL------RHNSVQLQVACMQLINALVT---SPDDLDFRLHIRNEFMRCGLKEILP 375

  Fly   635 KLRTHENETLDRHLDFFEMVRAEDEKEFARRFKEEHVDTKSAGSMFELLRRKLSHSPAYPHMLSL 699
            .|:..:|:.||..|..|:..:.||..|.:.|.::...:...|..::.::...:..:.|..:.:|:
Human   376 NLKCIKNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISI 440

  Fly   700 LQHMLLLPYTGHCTEHWL-LIDRVVQQIVLQVEQRPNSDLIVDPDDPEKQLKLAAESPVHDPDVA 763
            |||:||:.......:.:. |||..|.||||..:.       :|||...::
Human   441 LQHLLLIRNDYFIRQQYFKLIDECVSQIVLHRDG-------MDPDFTYRK--------------- 483

  Fly   764 PLQIDVAKLVRLLVKEEQLTQARKRADELERENFDVQSRLAKKEQELDLRMQEKEDLETGLARMR 828
            .|.:|:.:.|.:.:.:.:|.:..::|.||.:
Human   484 RLDLDLTQFVDICIDQAKLEEFEEKASELYK---------------------------------- 514

  Fly   829 ERLEKESAQHSQAVQRAQTAEMRAEDLQHRLISEQQERARLERLVTEGSIPDDQKVAGLTGCNGA 893
             :.|||...|.:.....|..|.:..:||..|   |..:::...|..:.:||......|.|| :.|
Human   515 -KFEKEFTDHQETQAELQKKEAKINELQAEL---QAFKSQFGALPADCNIPLPPSKEGGTG-HSA 574

  Fly   894 VSPPPAPPMLKAIPPPPPPMAPSMMPPPPPPCPG--------APPPPP---SMAQTMAPAP--PK 945
            :.|||..|....:|||||       ||||||.||        .|||||   ...|...|.|  |.
Human   575 LPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGPVPPPPPLGFLGGQNSPPLPILPF 632

  Fly   946 VDLPKKNVPQPTNPLKSFNWSKL-PDAKLQGTVWSELDESKLYNNMELE-SIDKLFSAYQKNGVS 1008
            ...|||.. :|...::..||.|: |....:...|.:::|:| |.|::|. .::..|...||.
Human   633 GLKPKKEF-KPEISMRRLNWLKIRPHEMTENCFWIKVNENK-YENVDLLCKLENTFCCQQKE--- 692

  Fly  1009 ATDGSYEDLRVTGKAAKQKV--LSVIDGRRAQNCTILLSKLKMSDMEISKAILSMDSNEQLQLDM 1071
              ....||:. ..|:.|:|:  |..:|.:.|||.:|.||..::...||...||.:|.. :|...|
Human   693 --RREEEDIE-EKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDET-RLAESM 753

  Fly  1072 VEQLLKFTPSAEERALLDEHSEDIESLARADRFLYEISKIPHYEQRLKSLHYKKRFMLTINDLVP 1136
            ::.|:|..|..|:...|.:...:..:|...::|:..:|.:.....||.::.:|.:|...:|::.|
Human   754 IQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIKP 818

  Fly  1137 RITSVMEASREVARSRRLRKLLELVLALGNYMNRGARGNAS--GFRLASLNRLADTKSSAAKGTT 1199
            .|.:|..|..|:.:|:...|||||||.:|||||.|:| ||.  ||.|:||.:|.||||:..| ||
Human   819 DIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSR-NAQTFGFNLSSLCKLKDTKSADQK-TT 881

  Fly  1200 LLHYLVQVIERKFKDLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEFHRSSGPAQ 1264
            |||:||::.|.|:.|:|...||:..:.:|||||:..::|:::.:...|..:.:|:|  ....|..
Human   882 LLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEKELE--TFPPPED 944

  Fly  1265 QGDRFLPVMREFHAQASVRFAELEDKFQDMKTRFDRAVRLFGEDGSVLQPDEFFGIFDSFLAAFA 1329
            ..|:|:..|..|...|..::..|....::|:..:...:..:..|...:..::|....::|...|.
Human   945 LHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFM 1009

  Fly  1330 EARHDNESFRRRQEEEEKRAKQEAELKKR-TIERKNKTGLMTSVARNLGLKSGSSNGDPDSPAKG 1393
            :|..:|.. :|..||:|||.:...||.:| .:||:.|.      .|.|.:|:            .
Human  1010 QAIKENIK-KREAEEKEKRVRIAKELAERERLERQQKK------KRLLEMKT------------E 1055

  Fly  1394 GDNKGEFDDLISALRTGDVFGEDMAKFKRSRKAR 1427
            ||..|..|:|:.||::|..|        |.|:.|
Human  1056 GDETGVMDNLLEALQSGAAF--------RDRRKR 1081

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:283920	57/240 (24%)
		Drf_FH3	551..737	CDD:283917	51/189 (27%)
		FliJ	779..>875	CDD:280262	15/95 (16%)
		FH2	950..1328	CDD:280362	115/383 (30%)
DIAPH3	NP_001035982.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..57		10/45 (22%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q9Z207	36..60		5/26 (19%)
		Drf_GBD	115..297	CDD:283920	47/191 (25%)
		Drf_FH3	305..488	CDD:283917	53/213 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	558..622		28/71 (39%)
		FH2	636..1008	CDD:280362	116/384 (30%)
		Nuclear export signal. /evidence=ECO:0000250\|UniProtKB:Q9Z207	1184..1193
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950