Protein Alignment DAAM and daam2

DIOPT Version :9

• Sequence 1: NP_001188522.1
• Gene: DAAM / 31075
• FlyBaseID: FBgn0025641
• Length: 1463
• Species: Drosophila melanogaster
• Sequence 2: XP_001338908.5
• Gene: daam2 / 798465
• ZFINID: ZDB-GENE-070709-1
• Length: 1095
• Species: Danio rerio
• Alignment Length: 1178
• Identity: 535/1178 - (45%)
• Similarity: 748/1178 - (63%)
• Gaps: 143/1178 - (12%)

  Fly   323 CFKDDEPPEICVVEGAFTLQTLTPTQPMPSVDELDTKFAELVEELDLTAPNKEAMLSLPAQKKWQ 387
            |||..||||| .::.:..||.|..:.|||..:||..:|:|||::||||..|:|||.:|||:||||
Zfish    16 CFKSGEPPEI-NLKDSVPLQLLEFSAPMPPEEELHARFSELVDDLDLTDKNREAMFALPAEKKWQ 79

  Fly   388 IYCSRKLPLDAADGPDAAAVTQPPTAEHYIERLKELVVHISLSPEDSPSHELGNRLDGHAAFVDA 452
            ||||:|   ...:.|:..|.:.|   ::||:|:..:....:|...|....|:.|::      |:.
Zfish    80 IYCSKK---KEQEDPNKLATSWP---DYYIDRINSMAAMQTLFAFDEAEIEMRNKV------VED 132

  Fly   453 LKTALRTSTHSFVLRFVELDGLPALLDLLLQLDIRVANSPLHTSLIGCIKALMNNSMGRAHVLAH 517
            |||||||....||.||:|||||..||..|..:|...:.|.:|||:|||||||||||.||||||||
Zfish   133 LKTALRTQPMRFVTRFIELDGLTCLLTFLRSMDYETSESRIHTSIIGCIKALMNNSQGRAHVLAH 197

  Fly   518 PTAIDTIARSLAADNIRTKIAALEILGAVCLVPGGHRKVLQAMLHFQVFATERTRFQSIVNDLDR 582
            |.:|:||::||..|||:||:|.|||||||||||.||:||||||.|:|.||.|||||||::|.|||
Zfish   198 PQSINTISQSLHQDNIKTKVAVLEILGAVCLVPDGHKKVLQAMAHYQKFAAERTRFQSLLNGLDR 262

  Fly   583 STYAYRDNVNLKTALMSFVNAVLNYGPGQENLEFRLHLRYEFLMLGIQPVIDKLRTHENETLDRH 647
            ||..|||.||||||:|||:||:||.|.|:|::|||||||||||||||||||:|||.|:|.|||||
Zfish   263 STGHYRDEVNLKTAIMSFINAMLNAGVGEESIEFRLHLRYEFLMLGIQPVIEKLRAHDNATLDRH 327

  Fly   648 LDFFEMVRAEDEKEFARRFKEEHVDTKSAGSMFELLRRKLSHSPAYPHMLSLLQHMLLLPY--TG 710
            ||||||||.|||.|.|:||...||||||||.||||:::||||:.||||:||:|||.|.:||  ..
Zfish   328 LDFFEMVRNEDELELAKRFDSMHVDTKSAGQMFELIKKKLSHTDAYPHLLSILQHCLKMPYKHDA 392

  Fly   711 HCTEHWLLIDRVVQQIVLQVEQRPNSDLIVDPDDPEKQLKLAAESPVHDPDVAPLQ-IDVAKLVR 774
            ...:.|.|:||::||||||.|...|                        |||:||: .:|..:::
Zfish   393 GSIQQWQLLDRILQQIVLQDENGEN------------------------PDVSPLENFNVRNIIK 433

  Fly   775 LLVKEEQLTQARKRADELERENFDVQSRLAKKEQELDLRMQEKEDLETGLARMRERLEKESAQHS 839
            :||.|.::.|.|.:|::..:|:.::.:||.:|::|.:.:.|||||:...|.:|:::|::|..:..
Zfish   434 MLVNENEVKQWRDQAEKFRKEHVELMTRLERKDRECETKTQEKEDMMKTLNKMKDKLQREGVELR 498

  Fly   840 QAVQRAQTAEMRAEDLQHRLISEQQERARLERLVTEGSIPDDQKVAGLTGCNGAVSPPPAPPM-- 902
            .|.::......|..|:.:..:                .:|....:.|    :....|||:||:
Zfish   499 SAKEQVLDMSSRISDISYVGV----------------PLPFPHPLPG----SPMPPPPPSPPIML 543

  Fly   903 ----LKAIPPPPPPMAPSMMPPPPPPCPGAPPPPPSMAQTMAPAPP------------------- 944
                |...||||||..|.:.||||||.|..||.|||.|.:..|.||
Zfish   544 GGSPLLFPPPPPPPPPPLLHPPPPPPPPLLPPLPPSFAFSSPPPPPPPPSFGCPQPPPGAPPIFS 608

  Fly   945 ----------KVDLPK-KNVPQPTNPLKSFNWSKLPDAKLQGTVWSELDESKLYNNMELESIDKL 998
                      ....|: |::|||:.||||||||||...::..|:|..:|:.:.:..::|:.|:|:
Zfish   609 GIPPGPASNSSTTSPQTKSIPQPSQPLKSFNWSKLGGNEITDTIWYGIDDRRAFKVLDLKDIEKM 673

  Fly   999 FSAYQKNGVSATDGSYEDLRVTGKAAKQKVLSVIDGRRAQNCTILLSKLKMSDMEISKAILSMDS 1063
            |||||:.  ....||.:||.::  |.|.|.||||||||||||.|||||||||:.|:.:|:|.||.
Zfish   674 FSAYQRQ--QKETGSMDDLNLS--ARKVKELSVIDGRRAQNCVILLSKLKMSNEELKRAVLEMDE 734

  Fly  1064 NEQLQLDMVEQLLKFTPSAEERALLDEHSEDIESLARADRFLYEISKIPHYEQRLKSLHYKKRFM 1128
            .|:|..||:||||||.|...:..||:||..::|.:|||||||:|:|:|.||:|||:||.:||:|.
Zfish   735 REELAKDMLEQLLKFVPEKSDMDLLEEHKHELERMARADRFLFEMSRIDHYQQRLQSLFFKKKFA 799

  Fly  1129 LTINDLVPRITSVMEASREVARSRRLRKLLELVLALGNYMNRGARGNASGFRLASLNRLADTKSS 1193
            ..:.:..|:..:::.|||||.||:.||::||:|||.||:||:|.||||.||:::|||::.|||||
Zfish   800 DRLAETKPKAEAILCASREVMRSKLLRQVLEVVLAFGNFMNKGQRGNAYGFKVSSLNKIIDTKSS 864

  Fly  1194 AAKGTTLLHYLVQVIERKFKDLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEF-H 1257
            ..:..|:||||:.:.|:.:.|:|.::.|:..|.||:||:|.|::|::..:|:||.  |.|:|. :
Zfish   865 IDRNITMLHYLIMIFEKNYPDILSIQQDLCSVSEAAKVNLAELEKEVSSIRSGLK--ALEVELRY 927

  Fly  1258 RSSGPAQQGDRFLPVMREFHAQASVRFAELEDKFQDMKTRFDRAVRLFGEDGSVLQPDEFFGIFD 1322
            :.|....:||:|:||:.:|...||..|:|||:...:.|.:|..|::.|||:...:||||||||||
Zfish   928 QQSRVCDRGDKFVPVVSDFITVASFSFSELEELLNEAKDKFSMALKHFGEEEGRMQPDEFFGIFD 992

  Fly  1323 SFLAAFAEARHDNESFRRRQEEEEKRAKQEAELK-KRTIERKNKTGLMTSVARNLGLKSGSSNGD 1386
            .||.:|:|||||.::.:|.:||||::.:.||.|| :|..||:.|.|...||:..:
Zfish   993 IFLQSFSEARHDLKNMQRCKEEEERKIRLEAMLKDQRERERRAKKGTKGSVSEEV---------- 1047

  Fly  1387 PDSPAKGGDNKGEFDDLISALRTGDVFGEDMAKFKRSRKARVLNGGGSSTGHTSPPRHGSLQREE 1451
                       ||||||:||||:|:||.:| :|.||:||..|                 :...:.
Zfish  1048 -----------GEFDDLVSALRSGEVFDKD-SKLKRNRKRSV-----------------NQLADA 1083

  Fly  1452 SGRERERT 1459
            .||||..|
Zfish  1084 GGRERSVT 1091

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:283920	102/198 (52%)
		Drf_FH3	551..737	CDD:283917	128/187 (68%)
		FliJ	779..>875	CDD:280262	21/95 (22%)
		FH2	950..1328	CDD:280362	182/379 (48%)
daam2	XP_001338908.5	Drf_GBD	41..228	CDD:283920	102/198 (52%)
		Drf_FH3	231..428	CDD:283917	133/220 (60%)
		FH2	626..999	CDD:280362	182/378 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	397	1.000	Domainoid score	I718
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1041	1.000	Inparanoid score	I261
OMA	1	1.010	-	-		QHG54599
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102298
Panther	1	1.100	-	-	LDO	PTHR45725
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1795
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.980