DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAAM and inf2

DIOPT Version :9

Sequence 1:	NP_001188522.1	Gene:	DAAM / 31075	FlyBaseID:	FBgn0025641	Length:	1463	Species:	Drosophila melanogaster
Sequence 2:	NP_001072591.1	Gene:	inf2 / 780046	XenbaseID:	XB-GENE-5862185	Length:	1380	Species:	Xenopus tropicalis

Alignment Length:	1111	Identity:	276/1111 - (24%)
Similarity:	480/1111 - (43%)	Gaps:	229/1111 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   424 VVHISLSPEDSPSHELGN----------RLDGHAAFVD--ALKTALRTSTHSFVLRFVELDGLPA 476
            |:...|.|:| |....||          ||....:.|:  .||..|.:|...::::|:||.||..
Frog    13 VLKQKLGPQD-PEQIEGNMENADPELCIRLLQIPSVVNYSGLKKRLESSDDDWMVQFLELSGLDL 76

  Fly   477 LLDLLLQLD----IRVANSPLHTSLIGCIKALMNNSMGRAHVLAHPTAIDTIARSLAADNIRTKI 537
            ||:.|.:|.    .|:|::.|..:.|.|::.|||:..|..:::.:...:..::::|...|:..|.
Frog    77 LLEALDRLSGRGVARIADALLQLTCINCVRTLMNSHRGIEYIVNNEGYVRKLSQALDTSNVMVKK 141

  Fly   538 AALEILGAVCLV-PGGHRKVLQAMLHFQVFATERTRFQSIVNDLDRSTYAYRDNVNLKTALMSFV 601
            ...|:|.|:|:. |.||...|.|:.|::....::.||..|:|:|..|     |||.....|:|.:
Frog   142 QVFELLAALCIYSPEGHALSLDALEHYKAVKNQQYRFSVIMNELSTS-----DNVPYMVTLLSAI 201

  Fly   602 NAVLNYGPGQENLEFRLHLRYEFLMLGIQPVIDKLRTHENETLDRHLDFFEMVRAEDEKEFARRF 666
            ||::.   |.|.|..|:.||.||:.|.:..::.|||..|:|.|......||..::|||:|..:.:
Frog   202 NAIIF---GTEELRKRVQLRNEFIGLQLLDLLTKLRDLEDEDLLIQAIVFEEAKSEDEEELLKIY 263

  Fly   667 KEEHVDTKSAGSMFELLRRKLSHSPAYPHMLSLLQHMLLLPYTGHCTEH--WLLIDRVVQQIVLQ 729
              ..:|..:...:|..|..|:|.||....:||:||.:|.|..: |.:..  |..:|.:|.:.||.
Frog   264 --GGIDMNNHQEVFSTLFNKVSCSPLSVQLLSVLQGLLHLDQS-HPSSPLLWEALDILVNRAVLL 325

  Fly   730 VE--QRPNSDLIVDPDDPEKQLKLAAESPVHDPDVAPLQIDVAKLVRLLVKEEQLTQARKRADEL 792
            .:  |..|.:.::|                                ||:..::..::.:::.|:.
Frog   326 ADDCQNNNVEEVMD--------------------------------RLVTSKKHPSKEKRKPDKC 358

  Fly   793 ERE-NFDVQSRLAKKEQELDLRMQEKEDLETGL----ARMRERL----------------EKESA 836
            ..: |..:|:. ..|::..:.:..:|:.:.:|:    .::.:.|                :..|.
Frog   359 TNQVNKSIQTD-KPKDESCEEKTVKKDPVSSGIPADSLQLSDALLALPACVSPLHTPLSGDITSP 422

  Fly   837 QH---------SQAVQRAQTAEMRAEDLQHRLISEQQERARLERLVTEGSI--PDDQKVAGLTGC 890
            .|         |.|:.|..|:......|...|..            ||.|:  |....:.|:.|.
Frog   423 SHFPSPPSPVVSNAIDRISTSSSLPPPLPPPLPG------------TELSLPPPPPPPLPGMGGI 475

  Fly   891 N------------GAVSPPPAPP---MLKAIPPPPPP------MAP----------SMMPPPPPP 924
            :            |.:.|||.||   |...:||||||      |.|          .|:||||||
Frog   476 SLTPPPPPPLPGMGGMLPPPPPPLPGMGGMLPPPPPPLPGMGGMLPPPPPPLPGMGGMLPPPPPP 540

  Fly   925 CP---GAPPPPPSMAQT--MAPAPP---------------KVD-----LPKK--NVPQPTNPLKS 962
            .|   |.|||||.:...  |.|.||               :||     |||.  .|.:||..:|.
Frog   541 LPGMGGMPPPPPPLPGMGGMPPPPPPMFGMGTFTDEVVVARVDYSLGYLPKAYFKVNKPTLKMKK 605

  Fly   963 FNWSKLPDAKLQGT--VWSELDESKLYNNMELESIDKLFSAYQKNGVSATDGSYEDLRVTGKAAK 1025
            .||.|||...:..|  :|:....|.........||::||...|                  ..||
Frog   606 LNWQKLPPNVINDTHSMWASASSSNDTPEPNYSSIEQLFCLPQ------------------AVAK 652

  Fly  1026 Q---------KVLSVIDGRRAQNCTILLSKLKMSDMEISKAILSMDSNEQLQLDMVEQLLKFTPS 1081
            :         |.:|.:|.::..|..|.|.:.|..:.|:.:.|...| ..:..:::::|.||..|.
Frog   653 EPAAPVKKPPKEISFLDSKKNLNLNIFLKQFKCPNEEVIQLIEKGD-RSRFDIEILKQFLKLLPE 716

  Fly  1082 AEERALLDEHSEDIESLARADRFLYEISKIPHYEQRLKSLHYKKRFMLTINDLVPRITSVMEASR 1146
            ..|...|..:.||...|:.||:|...:..||.|:.|::.:...:...|..:.|.|:...|..|..
Frog   717 KHEVENLKSYQEDKAKLSNADQFYLLLLGIPCYQLRIECMLICEEVNLMTDVLRPKAKVVSSACD 781

  Fly  1147 EVARSRRLRKLLELVLALGNYMNRGAR-GNASGFRLASLNRLADTKSSAAKGTTLLHYLVQVIER 1210
            ::..|.||....:|:|.:||::|.|:. |||:||::.:|.:|.:||::..: .||||::::.||:
Frog   782 DIISSHRLPLFCQLILKVGNFLNYGSHTGNANGFKIGTLLKLTETKANQNR-ITLLHHILEEIEQ 845

  Fly  1211 KFKDLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEFHRSSGPAQQGDRFLPVMRE 1275
            ...|||:|..|:.:|..|:.:::..|..:    .:|.....|:::...|:......|::...::|
Frog   846 NHTDLLQLPSDLENVSTAAGINIENMYSE----TSGNLKKLRDLQNKISTAATDVKDQYEKSIQE 906

  Fly  1276 FHAQASVRFAELEDKFQDMKTRFDRAVRLFGEDGSVLQPDEFFGIFDSFLAAFAEARHDNESFRR 1340
                ......|:|::..|:..:..:......||.:.|..:|.|....:|...|.:|:.||:..:.
Frog   907 ----CMDALKEVEEQLTDITQKKVKLADYLCEDSAKLSLEETFSTMKAFRDLFLKAKKDNKDRKE 967

  Fly  1341 RQEEEEKRAKQEAELKKRTIERKNKTG------------------LMTSVARNLGL-KSGSSNGD 1386
            :..:.|||.||.|:.:.:  .:|.:.|                  |:..:.:...| |:..:..:
Frog   968 QAVKAEKRKKQLADEEAK--RQKGENGKIIRKGAAKLEEGCIIDALLADIKKGFQLRKTAKTKTE 1030

  Fly  1387 PDSPAK 1392
            .||..|
Frog  1031 ADSCPK 1036

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:283920	38/139 (27%)
		Drf_FH3	551..737	CDD:283917	60/189 (32%)
		FliJ	779..>875	CDD:280262	15/125 (12%)
		FH2	950..1328	CDD:280362	97/391 (25%)
inf2	NP_001072591.1	Drf_GBD	<94..152	CDD:368864	13/57 (23%)
		Drf_FH3	156..332	CDD:368862	59/186 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..391		7/50 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	440..541		30/112 (27%)
		FH2	595..955	CDD:388631	96/387 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1026..1049		3/11 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1188..1244
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1260..1380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950