DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAAM and Daam2

DIOPT Version :9

Sequence 1:	NP_001188522.1	Gene:	DAAM / 31075	FlyBaseID:	FBgn0025641	Length:	1463	Species:	Drosophila melanogaster
Sequence 2:	NP_001008232.2	Gene:	Daam2 / 76441	MGIID:	1923691	Length:	1115	Species:	Mus musculus

Alignment Length:	1230	Identity:	545/1230 - (44%)
Similarity:	755/1230 - (61%)	Gaps:	196/1230 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   308 KKKMPGFRGRRVWCGCFKDDEPPEICVVEGAFTLQTLTPTQPMPSVDELDTKFAELVEELDLTAP 372
            :|:.|  .|....| ||...:.||| .:..:..||.|..:.|:|:.:||:.:|||||:|||||..
Mouse     4 RKRSP--HGLGFLC-CFGGSDLPEI-DLRDSHPLQYLEFSGPIPNPEELNVRFAELVDELDLTDK 64

  Fly   373 NKEAMLSLPAQKKWQIYCSRKLPLDAADGPDAAAVTQPPTAEHYIERLKELVVHISLSPEDSPSH 437
            |:||:.:||.:||||||||::   ...:.|:..|.:.|   |:||:|:..:....:|...:....
Mouse    65 NREAVFALPPEKKWQIYCSKR---KEQEDPNKLATSWP---EYYIDRINAMAAMQNLYETEDEET 123

  Fly   438 ELGNRLDGHAAFVDALKTALRTSTHSFVLRFVELDGLPALLDLLLQLDIRVANSPLHTSLIGCIK 502
            :..|::      |:.|||||||....||.||::|:||..||:.|..:|.....|.:|||||||||
Mouse   124 DKRNQV------VEDLKTALRTQPMRFVTRFIDLEGLTCLLNFLRGMDHTTCESRIHTSLIGCIK 182

  Fly   503 ALMNNSMGRAHVLAHPTAIDTIARSLAADNIRTKIAALEILGAVCLVPGGHRKVLQAMLHFQVFA 567
            ||||||.|||||||.|.||..||:||..:|.:||:|.||||||||||||||:||||||||:|.:|
Mouse   183 ALMNNSQGRAHVLAQPEAISIIAQSLRTENSKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQAYA 247

  Fly   568 TERTRFQSIVNDLDRSTYAYRDNVNLKTALMSFVNAVLNYGPGQENLEFRLHLRYEFLMLGIQPV 632
            .||||||:::|:||||...|||.||||||:|||:|||||.|.|::||||||||||||||||||||
Mouse   248 AERTRFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPV 312

  Fly   633 IDKLRTHENETLDRHLDFFEMVRAEDEKEFARRFKEEHVDTKSAGSMFELLRRKLSHSPAYPHML 697
            |||||.|||..||:|||||||||.||:.|.||||...|:|||||..||||:.:||.|:.|||.:|
Mouse   313 IDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELIHKKLKHTEAYPCLL 377

  Fly   698 SLLQHMLLLPY--TGHCTEHWLLIDRVVQQIVLQVEQRPNSDLIVDPDDPEKQLKLAAESPVHDP 760
            |:|.|.|.:||  .|...:.|.|:||::||||||.|:..                        ||
Mouse   378 SVLHHCLQMPYKRNGGYFQQWQLLDRILQQIVLQDERGV------------------------DP 418

  Fly   761 DVAPLQ-IDVAKLVRLLVKEEQLTQARKRADELERENFDVQSRLAKKEQELDLRMQEKEDLETGL 824
            |:|||: .:|..:|.:|:.|.::.|.|.:|::..:|:.::.|||.:||:|.:.:..|||::...|
Mouse   419 DLAPLENFNVKNIVNMLINENEVKQWRDQAEKFRKEHMELMSRLERKERECETKTLEKEEMMRTL 483

  Fly   825 ARMRERLEKESAQHSQAVQRAQTAEMRAEDLQHRLISEQQERARLERLVTEGSIPDDQKVAGLTG 889
            .:|:::|.:||.:..||  |.|.||         |::...|.:
Mouse   484 NKMKDKLARESQELRQA--RGQVAE---------LVARHNESS---------------------- 515

  Fly   890 CNGAVS--PPPAPPMLKA-------IPPPPPPMAPSMMPPPP-PPC-PGAPPPPPSMAQTMAPAP 943
             .|.||  |||..|:..:       :||||||:.....|||| ||. ||.||.||......:..|
Mouse   516 -TGPVSSPPPPGGPLTLSSSRTTNDLPPPPPPLPFDSCPPPPAPPLPPGGPPIPPGAPPCFSSGP 579

  Fly   944 P---------KVDLPKKNVPQPTNPLKSFNWSKLPDAKLQGTVWSELDESKLYNNMELESIDKLF 999
            |         :..|.||.:|||::|||||||.||.:.::.||||:|:|:|:::..::||..:|:|
Mouse   580 PPSHDPFSSNEAPLRKKRIPQPSHPLKSFNWVKLNEERVSGTVWNEIDDSQVFRILDLEDFEKMF 644

  Fly  1000 SAYQKNG-----------------------------------------VSATD-----GSYEDLR 1018
            ||||::.                                         ||||.     ||.||:.
Mouse   645 SAYQRHQACMQEGPQRERGNVRDGGAASRPLPAVEASAHRTEKASRSMVSATGAKKELGSTEDIY 709

  Fly  1019 VTGKAAKQKVLSVIDGRRAQNCTILLSKLKMSDMEISKAILSMDSNEQLQLDMVEQLLKFTPSAE 1083
            :|.:  |.|.||||||||||||.|||||||:|:.||.:|||.||..|.|..||:||||||.|...
Mouse   710 ITSR--KVKELSVIDGRRAQNCIILLSKLKLSNDEIRQAILRMDEQEDLAKDMLEQLLKFIPEKS 772

  Fly  1084 ERALLDEHSEDIESLARADRFLYEISKIPHYEQRLKSLHYKKRFMLTINDLVPRITSVMEASREV 1148
            :..||:||..:||.:|||||||||:|:|.||:|||::|.:||:|...:.:..|::.:::.||||:
Mouse   773 DIDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLASREL 837

  Fly  1149 ARSRRLRKLLELVLALGNYMNRGARGNASGFRLASLNRLADTKSSAAKGTTLLHYLVQVIERKFK 1213
            ..|:||:::||:|||:||:||:|.||.|.|||:||||::||||||..:..:|||||:.::|:.|.
Mouse   838 TLSQRLKQMLEVVLAIGNFMNKGQRGGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFP 902

  Fly  1214 DLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEF--HRSSGPAQQGDRFLPVMREF 1276
            |:|.:..::.|:.||:||:|.|::|::.:||.||..|..|:|:  |::..|   .|:|:|||.:|
Mouse   903 DILNMPSELKHLSEAAKVNLAELEKEVSILRRGLRAVEVELEYQRHQARDP---NDKFVPVMSDF 964

  Fly  1277 HAQASVRFAELEDKFQDMKTRFDRAVRLFGEDGSVLQPDEFFGIFDSFLAAFAEARHDNESFRRR 1341
            ...:|..|:||||:..:.:.:|.:|:..|||..|.:||||||||||:||.||.|||.|.|:.|||
Mouse   965 ITVSSFSFSELEDQLNEARDKFAKALTHFGEQESKMQPDEFFGIFDTFLQAFLEARQDLEAMRRR 1029

  Fly  1342 QEEEEKRAKQEAELK----KRTIERKNKTGLMTSVARNLGLKSGSSNGDPDSPAKGGDNKGEFDD 1402
            :||:|:||:.|..||    |...:|:.|.           |..|:.           :..|||||
Mouse  1030 KEEDERRARMEFMLKEQREKERWQRQRKV-----------LAGGAL-----------EESGEFDD 1072

  Fly  1403 LISALRTGDVFGEDMAKFKRSRKARVLNGGGSSTGHTSPPRHGSLQREESGRERERTVRR 1462
            |:||||:|:||.:|::||||:||                 |.||...|.:   |||.:.|
Mouse  1073 LVSALRSGEVFDKDLSKFKRNRK-----------------RPGSQVPEVT---RERAINR 1112

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:283920	96/198 (48%)
		Drf_FH3	551..737	CDD:283917	124/187 (66%)
		FliJ	779..>875	CDD:280262	27/95 (28%)
		FH2	950..1328	CDD:280362	194/425 (46%)
Daam2	NP_001008232.2	Drf_GBD	43..228	CDD:283920	95/196 (48%)
		Drf_FH3	231..435	CDD:283917	132/227 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..605		34/117 (29%)
		FH2	595..1016	CDD:280362	194/425 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..697		3/41 (7%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	387	1.000	Domainoid score	I798
eggNOG	1	0.900	-	-		E1_KOG1922
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1016	1.000	Inparanoid score	I284
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54599
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102298
Panther	1	1.100	-	-	LDO	PTHR45725
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	1	1.000	-	-		X1795
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.870