Protein Alignment DAAM and FMNL1

DIOPT Version :10

• Sequence 1: NP_001188522.1
• Gene: DAAM / 31075
• FlyBaseID: FBgn0025641
• Length: 1463
• Species: Drosophila melanogaster
• Sequence 2: NP_001398057.1
• Gene: FMNL1 / 752
• HGNCID: 1212
• Length: 1104
• Species: Homo sapiens
• Alignment Length: 1243
• Identity: 331/1243 - (26%)
• Similarity: 510/1243 - (41%)
• Gaps: 314/1243 - (25%)

  Fly   329 PPEICVVEGAFTLQTLTPTQPMPSVDELDTKFAELVEELDLTAPNKEAMLS-LPAQKKWQIYCSR 392
            ||:          |...|.||||:..||:.:|...:..::| .|:|..:|| ...:|||::.|.:
Human    18 PPK----------QPAPPKQPMPAAGELEERFNRALNCMNL-PPDKVQLLSQYDNEKKWELICDQ 71

  Fly   393 KLPLDAADGPDAAAVTQPPTAEHYIERLKELVVHISLSPEDSPS--HELG--NRLDGHAAFVDAL 453
                      :...|..||.|  ||::||..|....:|.:.:..  ..||  .|:......:..|
Human    72 ----------ERFQVKNPPAA--YIQKLKSYVDTGGVSRKVAADWMSNLGFKRRVQESTQVLREL 124

  Fly   454 KTALRTSTHSFVLRFV--ELDGLPALLDLLLQLDIRVA---------------NSPLHTSL---- 497
            :|:|||:...:|..|:  |..||..||:.|......|.               |.||..|:
Human   125 ETSLRTNHIGWVQEFLNEENRGLDVLLEYLAFAQCSVTYDMESTDNGASNSEKNKPLEQSVEDLS 189

  Fly   498 -----------------------------------------IGCIKALMNNSMGRAHVLAHPTAI 521
                                                     |.|::|:||...|.:.|:.||..:
Human   190 KGPPSSVPKSRHLTIKLTPAHSRKALRNSRIVSQKDDVHVCIMCLRAIMNYQSGFSLVMNHPACV 254

  Fly   522 DTIARSLAADNIRTKIAALEILGAVCLVPGGHRKVLQAMLHFQVFATERTRFQSIVNDLDRSTYA 586
            :.||.||...|.|||...||:|.|||||.|||..:|.|..:|:....|:.||:.::.       .
Human   255 NEIALSLNNKNPRTKALVLELLAAVCLVRGGHDIILAAFDNFKEVCGEQHRFEKLME-------Y 312

  Fly   587 YRD---NVNLKTALMSFVNAVLNYGPGQENLEFRLHLRYEFLMLGIQPVIDKLRTHENETLDRHL 648
            :|:   |::...|.|.|:|.|::   ..||:.||:.|:|||..||:...:::||..|::.|.
Human   313 FRNEDSNIDFMVACMQFINIVVH---SVENMNFRVFLQYEFTHLGLDLYLERLRLTESDKLQ--- 371

  Fly   649 DFFEMVRAEDEKEFARRFKEEHVDTKSAGSMFELLRRKLSHSPAYPHMLSLLQHMLLLPYTGHCT 713
               ..::|..:..|......|..:||:|                      :|:||
Human   372 ---VQIQAYLDNIFDVGALLEDTETKNA----------------------VLEHM---------- 401

  Fly   714 EHWLLIDRVVQQIVLQVEQRPNSDLIVDPDDPEKQLKLAAESPVHDPDVAPLQIDVAKLVRLLVK 778
                  :.:.:|:.|..|:.         .|.|.:                   .:||:..|
Human   402 ------EELQEQVALLTERL---------RDAENE-------------------SMAKIAEL--- 429

  Fly   779 EEQLTQARKRADELERENFDVQSRLAKKEQELDLRMQEKEDLETGLARMRERLEKESAQHSQAVQ 843
            |:||:||||..:.| ||.|..                     .|.:...|...|.|.|..: |..
Human   430 EKQLSQARKELETL-RERFSE---------------------STAMGPSRRPPEPEKAPPA-APT 471

  Fly   844 RAQTAEMRAEDLQH----RLISEQQERARLERLVTEGSIPD--DQKVAGL-TG------------ 889
            |....|::.|:|:.    |::....:...:|.|....:.|.  |....|: ||
Human   472 RPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEP 536

  Fly   890 CNGAVSPPPAP----PMLKAIPPPPPPMAP----SMMPPPPPPCPG----APPPPPSMAQTMAPA 942
            ..||..|||.|    |..:..||..||.||    |..|||.||.||    .|||||....|..|.
Human   537 APGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPV 601

  Fly   943 PPKVDLPKKNVPQPTNP--------------------------LKSFNWSKLPDAKLQGTVWSEL 981
            ||.   |....|.|..|                          :...||..|..:::.|||::||
Human   602 PPP---PPPPPPPPGGPPDALGRRDSELGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTVFTEL 663

  Fly   982 DESKLYNNMELESIDKLFSAYQKNGVSATDGSYEDLRVTGKAAKQKVLS---VIDGRRAQNCTIL 1043
            ::.|:...:::...::.|.       :.:.|...||......|.||..|   :|:..||:|..|.
Human   664 NDEKVLQELDMSDFEEQFK-------TKSQGPSLDLSALKSKAAQKAPSKATLIEANRAKNLAIT 721

  Fly  1044 LSKLKMSDMEISKAILSMDSNEQLQLDMVEQLLKFTPSAEERALL---DEHSEDIESLARADRFL 1105
            |.|..:....|.:||.:.|. :.|.||.:|.|::|.|:..||:|:   :.....:|.|:..|||:
Human   722 LRKGNLGAERICQAIEAYDL-QALGLDFLELLMRFLPTEYERSLITRFEREQRPMEELSEEDRFM 785

  Fly  1106 YEISKIPHYEQRLKSLHYKKRFMLTINDLVPRITSVMEASREVARSRRLRKLLELVLALGNYMNR 1170
            ...|:||...:|:.:|.:...|..|...|:|::.:::.||..:..|.:||::||:|||.|||||.
Human   786 LCFSRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMNS 850

  Fly  1171 GARGNASGFRLASLNRLADTKSSAAKGTTLLHYLVQVIERKFKDLLKLEDDIPHVREASKVSLGE 1235
            ..||.|.||||.||:.|.:.||:..| .|||||||:||..|:..|.....|:..:.:|..|||..
Human   851 SKRGAAYGFRLQSLDALLEMKSTDRK-QTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVSLDS 914

  Fly  1236 MDKDIQMLRTGLADVAREIEFHRSSGPAQQGDRFLPVMREFHAQASVRFAELEDKFQDMKT---R 1297
            :..|::.|:.||....||.        .:|.|  ..|::||....|....:|   ..|.||   .
Human   915 VLADVRSLQRGLELTQREF--------VRQDD--CMVLKEFLRANSPTMDKL---LADSKTAQEA 966

  Fly  1298 FDRAVRLFGEDGSVLQPDEFFGIFDSFLAAFAEARHDNESFRRRQEEEEKRA----KQEAELKKR 1358
            |:..|..|||:.....|..||.:|..|:.|:.:|..:.|.:::....:|..|    |.|....|.
Human   967 FESVVEYFGENPKTTSPGLFFSLFSRFIKAYKKAEQEVEQWKKEAAAQEAGADTPGKGEPPAPKS 1031

  Fly  1359 TIE-RKNKTGLMTSVARNLGLKSGSSNGDP---DSPAKGGDNKGEFDDLISALRTGDVFGEDMAK 1419
            ..: |:.:..|::.:.|.       ...:|   :|     |..|..:|:|:.||.......|..
Human  1032 PPKARRPQMDLISELKRR-------QQKEPLIYES-----DRDGAIEDIITDLRNQPYIRADTG- 1083

  Fly  1420 FKRSRKAR 1427
             :||.:.|
Human  1084 -RRSARRR 1090

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:461886	68/265 (26%)
		Drf_FH3	551..737	CDD:461885	42/188 (22%)
		Smc	<765..>875	CDD:440809	27/113 (24%)
		FH2	950..1328	CDD:396655	125/412 (30%)
FMNL1	NP_001398057.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		7/22 (32%)
		Drf_GBD	34..281	CDD:461886	65/259 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	167..200		4/32 (13%)
		Drf_FH3	284..>433	CDD:461885	48/233 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	446..474		8/49 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	510..635		39/127 (31%)
		FH2	633..998	CDD:396655	123/386 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1008..1037		5/28 (18%)