DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAAM and fhdc1

DIOPT Version :9

Sequence 1:	NP_001188522.1	Gene:	DAAM / 31075	FlyBaseID:	FBgn0025641	Length:	1463	Species:	Drosophila melanogaster
Sequence 2:	XP_002933539.2	Gene:	fhdc1 / 734113	XenbaseID:	XB-GENE-983433	Length:	1117	Species:	Xenopus tropicalis

Alignment Length:	606	Identity:	170/606 - (28%)
Similarity:	286/606 - (47%)	Gaps:	102/606 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   890 CNGAVS------PPPAPPMLKAIPPPPPPMAPSMMP----PPPPPCPGAPPPPPSMAQTMAPAPP 944
            ||..::      |||.||.   .||||||..|..:|    |||||.|||||||        |.|.
Frog    18 CNVVITELMVEQPPPPPPQ---PPPPPPPPPPPPLPFQNVPPPPPLPGAPPPP--------PLPH 71

  Fly   945 KVDLPKKNVPQPTNPLKSFNWSKLPDAKLQG--TVWSELDESKLYNNMELESIDKLFSAYQ--KN 1005
            :|.....| ....|.::||.|..:|:.:::|  .:|:...:.:.| .::.::|::||...:  ::
Frog    72 QVGNGHGN-NSKRNRMRSFFWKTIPEEQVRGKNNIWTMAAKQQQY-QIDTKTIEELFGQKEEPRS 134

  Fly  1006 GVSATDGSYEDLRVTGKAAKQKVLSVIDGRRAQNCTILLSKLKMSDMEISKAI----LSMDSNEQ 1066
            |:....|   :|:.:.:.||::| |::|.:|:.|..|.|.:.|.|..||...|    ..:...|.
Frog   135 GLIKAKG---NLKSSFREAKEEV-SLLDSKRSMNIGIFLKQFKKSTEEIIGDIREGRCDLYGPEP 195

  Fly  1067 LQLDMVEQLLKFTPSAEERALLDEHSEDIESLARADRFLYEISKIPHYEQRLKSLHYKKRFMLTI 1131
            ||     :|||.:|.:||...|...|.::..|:.||.|:|.:.::|:|..|::::..:|.|....
Frog   196 LQ-----ELLKLSPESEEIKKLKAFSGEVAKLSLADTFMYLLIQVPNYSLRIEAMVLRKEFGSCH 255

  Fly  1132 NDLVPRITSVMEASREVARSRRLRKLLELVLALGNYMNRGA-RGNASGFRLASLNRLADTKSSAA 1195
            :.|...:|.:..|::|:....:|..:|.|||..||.||.|. .|||.||:|:||.||||||:: .
Frog   256 SALKNDMTVIRVATKELMSCEQLHSILFLVLQAGNIMNAGGYAGNAVGFKLSSLLRLADTKAN-K 319

  Fly  1196 KGTTLLHYLVQVIERKFKDLLKLEDDIPHVREASKVSLGEMDKDIQMLRT---GLAD-VAREIEF 1256
            .|..|||::....::|...||...:.:|.|.||:::|:..|:.:.:.|.|   .:.| :.:|.|.
Frog   320 PGMNLLHFVALEAQKKDVSLLTFSEKLPSVGEAARLSIDNMEAEFKSLSTKTKSIKDQIKKEPEL 384

  Fly  1257 HRSSGPAQQGDRFLPVMREFHAQASVRFAELEDKFQDMKTRFDRAVRLFGEDGSVLQPDEFFGIF 1321
            ::.             |.:|...|.....:||....::|......:..|.||...::.||.|.||
Frog   385 YKQ-------------MEDFLKDAVKDLKDLESLRAEIKKECHTLIDFFCEDKETMKLDECFQIF 436

  Fly  1322 DSFLAAFAEARHDNESFRRRQEEEEKRAKQEAELKKRTIERKNKTGLMTSVARNLGLKSGSSNGD 1386
            ..|...|.:|..:|   |.|:.::.::.|:..||     |:|.::.:   .:.|......||..|
Frog   437 RDFCDKFNKAVKEN---REREIQDLRKQKKLNEL-----EQKRRSWV---ASENANFGRSSSEND 490

  Fly  1387 PDSPAKGGDNKGEFDDLI-----SALRTGDVFGEDMAKFKRSRKARVLNG-----------GGSS 1435
            .:...|.|     .:|.:     |:|.          :...:|::|:..|           |.|.
Frog   491 VEILTKAG-----LEDFLQQRPQSSLN----------RNSSTRRSRLSLGVAADRELQMYLGASQ 540

  Fly  1436 TGHTSPPRHGSLQREESGRER 1456
            ...|: .:..||.|..:.:.|
Frog   541 VEETT-SKFNSLPRSHTHKPR 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:283920
		Drf_FH3	551..737	CDD:283917
		FliJ	779..>875	CDD:280262
		FH2	950..1328	CDD:280362	111/390 (28%)
fhdc1	XP_002933539.2	FH2	82..444	CDD:396655	110/385 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920