Protein Alignment DAAM and INF2

DIOPT Version :10

• Sequence 1: NP_001188522.1
• Gene: DAAM / 31075
• FlyBaseID: FBgn0025641
• Length: 1463
• Species: Drosophila melanogaster
• Sequence 2: NP_001413791.1
• Gene: INF2 / 64423
• HGNCID: 23791
• Length: 1268
• Species: Homo sapiens
• Alignment Length: 1142
• Identity: 285/1142 - (24%)
• Similarity: 489/1142 - (42%)
• Gaps: 219/1142 - (19%)

  Fly   382 AQKKWQIYCSRKLPLDAADGPDAAAVTQPPTAEHYIERLKELVVHISLSPEDSPSHELGNRLDGH 446
            ||:||.....:..|.| :|..:|...:..|          ||.:.:...|.......|..||:|
Human     7 AQRKWAALKEKLGPQD-SDPTEANLESADP----------ELCIRLLQMPSVVNYSGLRKRLEG- 59

  Fly   447 AAFVDALKTALRTSTHSFVLRFVELDGLPALLDLLLQLD----IRVANSPLHTSLIGCIKALMNN 507
                         |...::::|:|..||..||:.|.:|.    .|::::.|..:.:.|::|:||:
Human    60 -------------SDGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNS 111

  Fly   508 SMGRAHVLAHPTAIDTIARSLAADNIRTKIAALEILGAVCLV-PGGHRKVLQAMLHFQVFATERT 571
            ..|..::|::...:..::::|...|:..|....|:|.|:|:. |.||...|.|:.|::...:::.
Human   112 RQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQY 176

  Fly   572 RFQSIVNDLDRSTYAYRDNVNLKTALMSFVNAVLNYGPGQENLEFRLHLRYEFLMLGIQPVIDKL 636
            ||..::|:|..|     |||.....|:|.:|||: .||  |:|..|..||.||:.|.:..|:.:|
Human   177 RFSIVMNELSGS-----DNVPYVVTLLSVINAVI-LGP--EDLRARTQLRNEFIGLQLLDVLARL 233

  Fly   637 RTHENETLDRHLDFFEMVRAEDEKEFARRFKEEHVDTKSAGSMFELLRRKLSHSPAYPHMLSLLQ 701
            |..|:..|...|:.||..:||||:|..|  ....||..|...:|..|..|:|.||....:||:||
Human   234 RDLEDADLLIQLEAFEEAKAEDEEELLR--VSGGVDMSSHQEVFASLFHKVSCSPVSAQLLSVLQ 296

  Fly   702 HMLLLPYTGHCTE-HWLLIDRVVQQIVLQVEQRPNSDLIVDPDDPEKQLKLAAESPVHDPDVAPL 765
            .:|.|..|...:: .|..::.:|.:.||                      ||:     |.....|
Human   297 GLLHLEPTLRSSQLLWEALESLVNRAVL----------------------LAS-----DAQECTL 334

  Fly   766 QIDVAKLVRLLVKEEQLTQARKRADELERENFDVQSRLAKKEQELDLRMQEKEDLETGLARMRER 830
            :..|.:|:.:        :.|.|...|.:.:..||:.|.:.::              |.:.....
Human   335 EEVVERLLSV--------KGRPRPSPLVKAHKSVQANLDQSQR--------------GSSPQNTT 377

  Fly   831 LEKESAQHSQAVQRAQTAEMRAEDLQH----RLISEQQERARLERLVTEGSIPDDQKVAGLTGCN 891
            ..|.|.:..|     ..|....|.:.|    .::...|.|| ||:..:....|....:  |.|.:
Human   378 TPKPSVEGQQ-----PAAAAACEPVDHAQSESILKVSQPRA-LEQQASTPPPPPPPPL--LPGSS 434

  Fly   892 GAVSPPPAPPML-----KAIP--PPPPP------MAP-------------SMMPPPPPPCP--GA 928
            ....|||.||.|     ||:|  |||||      |||             ..:||||||.|  |.
Human   435 AEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGC 499

  Fly   929 PPPPPSMAQTMA---PAPPKVDLP------------------------------KKNVPQPTNPL 960
            |||||.:...|.   |.||...||                              .:.|..||..:
Human   500 PPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRM 564

  Fly   961 KSFNWSKLPD--AKLQGTVWSELDESKLYNNMELESIDKLFSAYQKNGVSATDGSYEDLRVTGKA 1023
            |..||.|||.  |:...::|:.|      ::.:.|:::..||:.::..........|...|..:|
Human   565 KKLNWQKLPSNVAREHNSMWASL------SSPDAEAVEPDFSSIERLFSFPAAKPKEPTMVAPRA 623

  Fly  1024 AKQ-KVLSVIDGRRAQNCTILLSKLKMSDMEISKAILSMDSNEQLQLDMVEQLLKFTPSAEERAL 1087
            .|: |.::.:|.:::.|..|.|.:.|.|:.|::..|.:.|:. :..:::::||||..|...|...
Human   624 RKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTT-KFDVEVLKQLLKLLPEKHEIEN 687

  Fly  1088 LDEHSEDIESLARADRFLYEISKIPHYEQRLKSLHYKKRFMLTINDLVPRITSVMEASREVARSR 1152
            |...:|:...||.||.|...:..||.|:.|::.:...:.....::.:.|:...|:.|...:..||
Human   688 LRAFTEERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTSR 752

  Fly  1153 RLRKLLELVLALGNYMNRGAR-GNASGFRLASLNRLADTKSSAAKGTTLLHYLVQVIERKFKDLL 1216
            :|....:|:|.:||::|.|:. |:|.||::::|.:|.:|||...: .||||::::..|:...|||
Human   753 QLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNR-VTLLHHVLEEAEKSHPDLL 816

  Fly  1217 KLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEFHRSSGPAQQGDRFLPVMREFHAQAS 1281
            :|..|:....:|:.::|..:..:.......|.:..|::....:....|..:|.         |||
Human   817 QLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQYTERL---------QAS 872

  Fly  1282 V-RFAELEDKFQDMKTRFDRAVRLFGEDGSVLQPDEFFGIFDSFLAAFAEARHDNESFRRRQEEE 1345
            : .|..|::.|:.::.:.........||...|..::.|....:|...|..|..:|:..:.:..:.
Human   873 ISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKA 937

  Fly  1346 EKRAKQEAELKKRTIERKNKTGLMTSVARNLGLKSGSSNGDPDSPAKGGDNKGE----FDDLISA 1406
            |:|.:|.||.:.|                       ...|:...|.:.|..|.|    .|.|::.
Human   938 ERRKQQLAEEEAR-----------------------RPRGEDGKPVRKGPGKQEEVCVIDALLAD 979

  Fly  1407 LRTGDVFGEDMAKFKRSRKARVLNGGGSSTGHTSPPR 1443
            :|.|       .:.:::.:.|....|||......|||
Human   980 IRKG-------FQLRKTARGRGDTDGGSKAASMDPPR 1009

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:461886	39/169 (23%)
		Drf_FH3	551..737	CDD:461885	62/186 (33%)
		Smc	<765..>875	CDD:440809	21/113 (19%)
		FH2	950..1328	CDD:396655	94/382 (25%)
INF2	NP_001413791.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29		7/22 (32%)
		Drf_GBD	<8..152	CDD:461886	38/168 (23%)
		Drf_FH3	156..341	CDD:461885	67/221 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	347..489		38/163 (23%)
		FH2	554..920	CDD:418645	94/382 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	928..966		9/60 (15%)
		WH2_INF2	966..995	CDD:409204	7/35 (20%)
		actin-binding sequence	986..989	CDD:409204	0/2 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	988..1076		7/22 (32%)