Protein Alignment DAAM and Fmnl1

DIOPT Version :9

• Sequence 1: NP_001188522.1
• Gene: DAAM / 31075
• FlyBaseID: FBgn0025641
• Length: 1463
• Species: Drosophila melanogaster
• Sequence 2: XP_006533900.1
• Gene: Fmnl1 / 57778
• MGIID: 1888994
• Length: 1113
• Species: Mus musculus
• Alignment Length: 1254
• Identity: 323/1254 - (25%)
• Similarity: 516/1254 - (41%)
• Gaps: 327/1254 - (26%)

  Fly   329 PPEICVVEGAFTLQTLTPTQPMPSVDELDTKFAELVEELDLTAPNKEAMLS-LPAQKKWQIYCSR 392
            ||:          |...|.||||:..||:.:|..::..::| .|:|..:|| ...:|||::.|.:
Mouse    18 PPK----------QPAVPKQPMPAAGELEERFTRVLNCMNL-PPDKVQLLSQYDNEKKWELICDQ 71

  Fly   393 KLPLDAADGPDAAAVTQPPTAEHYIERLKELV--VHISLSPEDSPSHELG--NRLDGHAAFVDAL 453
                      :...|..||.|  ||::||..:  ..:|..........||  .|:......:..|
Mouse    72 ----------ERFQVKNPPAA--YIQKLKSYLDTGGVSRKVASDWMSNLGFKRRVQESTQVLREL 124

  Fly   454 KTALRTSTHSFVLRFV--ELDGLPALLDLLL---------------------------------- 482
            :|:|||:...:|..|:  |..||..||:.|.
Mouse   125 ETSLRTNHIGWVQEFLNEENRGLDVLLEYLAFAQCSVAYDMESTDSVASGAEKSKPLDQSVEDLS 189

  Fly   483 ----------QLDIRVANSP--LHTSL--------------------------------IGCIKA 503
                      :|.|:...||  :|..|                                |.|::|
Mouse   190 KAPPSSVPKSRLTIKCPPSPRYVHRHLGAGACWGLTPAHSRKALRNSRIVSQKDDVHVCIMCLRA 254

  Fly   504 LMNNSMGRAHVLAHPTAIDTIARSLAADNIRTKIAALEILGAVCLVPGGHRKVLQAMLHFQVFAT 568
            :||...|.:.|:.||..::.||.||...:.|||...||:|.|||||.|||..:|.|..:|:....
Mouse   255 IMNYQSGFSLVMNHPACVNEIALSLNNKSPRTKALVLELLAAVCLVRGGHDIILAAFDNFKEVCG 319

  Fly   569 ERTRFQSIVNDLDRSTYAYRD-NVNLKTALMSFVNAVLNYGPGQENLEFRLHLRYEFLMLGIQPV 632
            |:.||:.::     ..:.:.| |::...|.|.|:|.|::   ..||:.||:.|:|||..||:...
Mouse   320 EQHRFEKLM-----EYFRHEDSNIDFMVACMQFINIVVH---SVENMNFRVFLQYEFTHLGLDLY 376

  Fly   633 IDKLRTHENETLDRHLDFFEMVRAEDEKEFARRFKEEHVDTKSAGSMFELLRRKLSHSPAYPHML 697
            :::||..|::.|.      ..::|..:..|......|..:||:|
Mouse   377 LERLRLTESDKLQ------VQIQAYLDNVFDVGTLLEETETKNA--------------------- 414

  Fly   698 SLLQHMLLLPYTGHCTEHWLLIDRVVQQIVLQVEQRPNSDLIVDPDDPEKQLKLAAESPVHDPDV 762
             :|:||                :.:.:|:....|:..:::                    :|
Mouse   415 -VLEHM----------------EELQEQVATLTERLRDTE--------------------ND--- 439

  Fly   763 APLQIDVAKLVRLLVKEEQLTQARKRADELERENFD------VQSRLAKKEQ----------ELD 811
                 .:||:..|   |:||:||||..:.| ||.|.      ...|:.:.|:          .|:
Mouse   440 -----SMAKIAEL---EKQLSQARKELETL-RERFSESTPMGTSRRIPEPEKVPVPTVVRPSALE 495

  Fly   812 LRMQEKEDLETGLARMRERLEKESAQHSQAVQRAQTAEMRAEDLQHRLISEQQERARLERLVTEG 876
            |:::|.|  |.||.|:   |.......|..:.....|....:|.|...:|.....       |..
Mouse   496 LKVEELE--EKGLIRI---LRGPGDVVSIEILPGAAATPSGDDAQAPRVSTDSPS-------TAE 548

  Fly   877 SIPDDQKVAGLTGCNGAVSPPPAPPMLKAIPPPP---------------PPMAPSM----MPPPP 922
            |||:            |.||||.||     ||||               ||:||.:    .|||.
Mouse   549 SIPE------------AASPPPPPP-----PPPPPLPNLQSQQEAPPSAPPLAPPLPGCAEPPPA 596

  Fly   923 PPCPG--APPPPPSMAQTMAPAPPKVDLPKKNVP--------------QPTNPLKS------FNW 965
            ||.||  .|||||....|..|.||....|....|              :...|:::      .||
Mouse   597 PPLPGDLPPPPPPPPLGTDGPVPPPPPPPPGGPPDILGGQGPDIGPGVKAKKPIQTKFRMPLLNW 661

  Fly   966 SKLPDAKLQGTVWSELDESKLYNNMELESIDKLFSAYQKN---GVSATDGSYEDLRVTGKAAKQK 1027
            ..|..:::.|||::||::.|:...:::...::.|....:.   .:||..|     :.:.||..:.
Mouse   662 VALKPSQITGTVFTELNDEKVLQELDMNDFEEHFKTKSQGPCLDISALKG-----KASQKAPTKT 721

  Fly  1028 VLSVIDGRRAQNCTILLSKLKMSDMEISKAILSMDSNEQLQLDMVEQLLKFTPSAEERALL---D 1089
            :|  |:..||:|..|.|.|..:....|.:||.:.|. :.|.||.:|.|.:|.|:..||:|:   :
Mouse   722 IL--IEANRAKNLAITLRKGNLGADRICQAIETYDL-QTLSLDFLELLTRFLPTDYERSLIARFE 783

  Fly  1090 EHSEDIESLARADRFLYEISKIPHYEQRLKSLHYKKRFMLTINDLVPRITSVMEASREVARSRRL 1154
            :....:|.|:..|||:...|:|....:|:.:|.:...|..|...|:|::.:::.||..:..|.:|
Mouse   784 KEQRPMEELSEEDRFMLRFSRIQRLPERMNTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKL 848

  Fly  1155 RKLLELVLALGNYMNRGARGNASGFRLASLNRLADTKSSAAKGTTLLHYLVQVIERKFKDLLKLE 1219
            |::||:|||.|||||...||.|.||||.||:.|.:.||:..| .|||||||:||..|:..|....
Mouse   849 RQILEIVLAFGNYMNSSKRGAAYGFRLQSLDALLEMKSTDRK-QTLLHYLVKVIAEKYPQLTGFH 912

  Fly  1220 DDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEFHRSSGPAQQGDRFLPVMREFHAQASVRF 1284
            .|:..:.:|..|||..:..|::.|:.||....||.        .:|.|..  |::||....|...
Mouse   913 SDLHFLDKAGSVSLDSVLGDVRSLQRGLELTQREF--------VRQDDCL--VLKEFLRANSPTM 967

  Fly  1285 AELEDKFQDMKT---RFDRAVRLFGEDGSVLQPDEFFGIFDSFLAAFAEARHDNESFRRRQEEEE 1346
            .:|   ..|.||   .::..|..|||:.....|..||.:|..|..|:.:|..:.|.:::....:.
Mouse   968 DKL---LADSKTAQEAYESVVEYFGENPKTTSPSMFFSLFSRFTKAYKKAEQEVEQWKKEAAADT 1029

  Fly  1347 KRAKQEAELKKRTIERKNKTGLMTSVARNLGLKSGSSNGDP---DSPAKGGDNKGEFDDLISALR 1408
            ...::....|.....|:.:..|::.:.|       ....:|   :|     |..|..:|:|:.||
Mouse  1030 SGREEPPTPKSPPKARRQQMDLISELKR-------KQQKEPLIYES-----DRDGAIEDIITDLR 1082

  Fly  1409 TGDVFGEDMAKFKRSRKAR 1427
            .......|..  :||.:.|
Mouse  1083 NQPYIRADTG--RRSARRR 1099

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:283920	67/283 (24%)
		Drf_FH3	551..737	CDD:283917	41/186 (22%)
		FliJ	779..>875	CDD:280262	27/111 (24%)
		FH2	950..1328	CDD:280362	121/406 (30%)
Fmnl1	XP_006533900.1	Drf_GBD	28..299	CDD:368864	67/283 (24%)
		Drf_FH3	302..>451	CDD:368862	46/231 (20%)
		FH2	647..1012	CDD:366959	121/386 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54599
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950