Protein Alignment DAAM and FMN2

DIOPT Version :10

• Sequence 1: NP_001188522.1
• Gene: DAAM / 31075
• FlyBaseID: FBgn0025641
• Length: 1463
• Species: Drosophila melanogaster
• Sequence 2: NP_001292353.1
• Gene: FMN2 / 56776
• HGNCID: 14074
• Length: 1726
• Species: Homo sapiens
• Alignment Length: 581
• Identity: 144/581 - (24%)
• Similarity: 247/581 - (42%)
• Gaps: 119/581 - (20%)

  Fly   892 GAVSPPPAPPMLKAIPP---------PPPPMAPSMMPPPPPPCPGA--PPPPPSMAQTMAPAP-P 944
            ||..|||.|.....|||         ||||..|.:..|||||.|||  |||||.....:.||| |
Human  1163 GAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAP 1227

  Fly   945 KVDLPKKNVP------------------------------------------------------Q 955
            .:..|...:|                                                      :
Human  1228 PLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPPLPSGLFGLGMNQDKGSRKQPIE 1292

  Fly   956 PTNPLKSFNWSKLP-----DAKLQGTVWSELDESKLYNNMELESIDKLFSAYQKNGVSATDGSYE 1015
            |..|:|...|:::.     |:. ...:|.:::|.    :::....::|||   |..|........
Human  1293 PCRPMKPLYWTRIQLHSKRDSS-TSLIWEKIEEP----SIDCHEFEELFS---KTAVKERKKPIS 1349

  Fly  1016 DLRVTGKAAKQKVLSVIDGRRAQNCTILLSKLKMSDMEISKAILSMDSNEQLQLDMVEQLLKFTP 1080
            |  ...|...::|:.::..:|:|...||:|.|.:...:|..|::::| |..:.|:.::.|.:...
Human  1350 D--TISKTKAKQVVKLLSNKRSQAVGILMSSLHLDMKDIQHAVVNLD-NSVVDLETLQALYENRA 1411

  Fly  1081 SAEERALLDEH------SEDIESLARADRFLYEISKIPHYEQRLKSLHYKKRFMLTINDLVPRIT 1139
            .::|...:::|      .|:.:||.:.::||||:|.||::.:|:..:.::..|..:|..:..::.
Human  1412 QSDELEKIEKHGRSSKDKENAKSLDKPEQFLYELSLIPNFSERVFCILFQSTFSESICSIRRKLE 1476

  Fly  1140 SVMEASREVARSRRLRKLLELVLALGNYMNRG--ARGNASGFRLASLNRLADTKSSAAKGTTLLH 1202
            .:.:....:.....:.::|.||||.|||||.|  .||.|.||.|..|.:|.|.||| ....:||.
Human  1477 LLQKLCETLKNGPGVMQVLGLVLAFGNYMNGGNKTRGQADGFGLDILPKLKDVKSS-DNSRSLLS 1540

  Fly  1203 YLVQVIERKFKDLLKLED---DIPHVR---EASKVSLGEMDKDIQMLRTGLADVAREIE----FH 1257
            |:|....|.|.:....|.   .:|..:   :||::...:..||::.|:..|.  |.|:|    :.
Human  1541 YIVSYYLRNFDEDAGKEQCLFPLPEPQDLFQASQMKFEDFQKDLRKLKKDLK--ACEVEAGKVYQ 1603

  Fly  1258 RSSGPAQQGDRFLPVMREFHAQASVRFAELEDKFQDMKTRFDRAVRLF------GEDGSVLQPDE 1316
            .||....|  .|...|.:|..||.:.....|:...:....|......|      ||  ..:.|:.
Human  1604 VSSKEHMQ--PFKENMEQFIIQAKIDQEAEENSLTETHKCFLETTAYFFMKPKLGE--KEVSPNA 1664

  Fly  1317 FFGIFDSFLAAFAEA-RHDNESF---RRRQEEEEKRAKQEAELKKRTIERKNKTGLMTSVA 1373
            ||.|:..|.:.|.:. :.:|:..   |.::.||..|.|:...|.|  |:.::.:|:...::
Human  1665 FFSIWHEFSSDFKDFWKKENKLLLQERVKEAEEVCRQKKGKSLYK--IKPRHDSGIKAKIS 1723

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:461886
		Drf_FH3	551..737	CDD:461885
		Smc	<765..>875	CDD:440809
		FH2	950..1328	CDD:396655	101/460 (22%)
FMN2	NP_001292353.1	DamX	<93..361	CDD:442497
		PHA03307	230..>500	CDD:223039
		FH2	1287..1677	CDD:396655	100/407 (25%)