DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAAM and Diaph3

DIOPT Version :9

Sequence 1:	NP_001188522.1	Gene:	DAAM / 31075	FlyBaseID:	FBgn0025641	Length:	1463	Species:	Drosophila melanogaster
Sequence 2:	NP_062644.1	Gene:	Diaph3 / 56419	MGIID:	1927222	Length:	1171	Species:	Mus musculus

Alignment Length:	1150	Identity:	312/1150 - (27%)
Similarity:	521/1150 - (45%)	Gaps:	189/1150 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   322 GCFKDDEP-PEICVVEGAFTLQTLTP------TQPMPSVDELDTKFAELVEELDLTAPNKEAMLS 379
            |..|:..| |.:..|.|.....:|:.      .:.:|..:.|.. |.:::|:::|   |::
Mouse    61 GSKKERPPLPHLKTVSGISDSSSLSSETMENNPKALPESEVLKL-FEKMMEDMNL---NED---- 117

  Fly   380 LPAQKKWQIYCSRKLPLDAAD-GPDAAAVTQPPTAEHYI---ERLKELVVHISLSPEDSPSHEL- 439
                        :|.||...| |.....|.|      ||   .:...|.....:||::. .|||
Mouse   118 ------------KKAPLREKDFGIKKEMVMQ------YINTASKTGSLRSSRQISPQEF-LHELK 163

  Fly   440 -GNRLDGHAAFVDALKTALRTSTHSFVLRFVELDGLPALLDLLL-----QLDIRVANSPLHTSLI 498
             |...:....::::|:.:|.:...|:|..|.. :||..|||:|.     |:..:|.....| .:|
Mouse   164 MGYTDERLFTYLESLRVSLTSHPVSWVQSFGH-EGLGLLLDILEKLINGQIQEKVVKKTQH-KVI 226

  Fly   499 GCIKALMNNSMGRAHVLAHPTAIDTIARSLAADNIRTKIAALEILGAVCLVPGGHRKVLQAMLHF 563
            .|::||||...|...:::...::..:|:::...........:::|.|||:|  |...:|:.:|..
Mouse   227 QCLRALMNTQYGLERIMSDKRSLSLLAKAMDPRQPAMMADVVKLLSAVCIV--GEESILEEVLEA 289

  Fly   564 QVFATER---TRFQSIVNDLDRSTYAYRDNVNLKTALMSFVNAVLNYGPGQENLEFRLHLRYEFL 625
            ...|.|.   .||.|||..|      ..::|||:.|.|..:||::.   ..::|:||||||.||:
Mouse   290 LTSAGEERKIDRFFSIVEGL------RHNSVNLQVACMQLINALVT---SPDDLDFRLHLRNEFM 345

  Fly   626 MLGIQPVIDKLRTHENETLDRHLDFFEMVRAEDEKEFARRFKEEHVDTKSAGSMFELLRRKLSHS 690
            ..|::.::..|:..:|:.||..|..|:..:.||..||..|.::...:...|..::.:|...:..:
Mouse   346 RCGLKEILPNLKGIKNDGLDIQLKVFDEHKEEDLSEFFHRLEDIRAELDEASDVYSMLWDTVKET 410

  Fly   691 PAYPHMLSLLQHMLLLPYTGHCTEHWL-LIDRVVQQIVLQVEQRPNSDLIVDPDDPEKQLKLAAE 754
            .|..|.||:|||:||:.......|.:. |||..|.||||..:.       .|||...::
Mouse   411 RAEGHFLSILQHLLLIRNDRFIREQYFKLIDECVSQIVLHRDG-------TDPDFTYRK------ 462

  Fly   755 SPVHDPDVAPLQIDVAKLVRLLVKEEQLTQARKRADELERENFDVQSRLAKKEQELDLRMQEKED 819
                     .|.:|:::.|.:.:.:.:|.:..::|.|
Mouse   463 ---------RLDLDLSQFVDVCIDQAKLDEWEEKASE---------------------------- 490

  Fly   820 LETGLARMRERLEKESAQHSQAVQRAQTAEMRAEDLQHRLISEQQERARLERLVTE-GSIPDDQK 883
                   ..::.|||...|.:...:.|..|.:..:||          |.|:...:: |::|...|
Mouse   491 -------HCKKFEKECTDHQETQAQLQKREAKINELQ----------AELQAFKSQFGALPPGTK 538

  Fly   884 VAGLTGCNGAVSP---PPAPPMLK-AIPPPPPPMAPSMMPPPPPPCPGAP-------PPPPSM-- 935
            :.......|...|   |||||.|. .:||||||     .||||||.||.|       ||||.:
Mouse   539 IPLQPSVEGEAGPSALPPAPPALSGGVPPPPPP-----PPPPPPPLPGMPMPFGGPVPPPPPLGF 598

  Fly   936 --AQTMAPAPPKVDLPKKNVPQPTNPLKSFNWSKL-PDAKLQGTVWSELDESKLYNNMELESIDK 997
              .|:..|......|..|...:|...::..||.|: |:...:...|.:::|:|..|...|..::.
Mouse   599 LGGQSSIPLNLPFGLKPKKEFKPEISMRRLNWLKIGPNEMSENCFWIKVNENKYENRDLLCKLEN 663

  Fly   998 LFSAYQKNGVSATDGSYEDLRVTGKAAKQKVLSVIDGRRAQNCTILLSKLKMSDMEISKAILSMD 1062
            .|...:|...:..|  :::.:|..|  :.|.|..:|.:.|||.:|.||..::...:|...||.:|
Mouse   664 TFCCQEKEKRNTND--FDEKKVIKK--RMKELKFLDPKIAQNLSIFLSSFRVPYEKIRTMILEVD 724

  Fly  1063 SNEQLQLDMVEQLLKFTPSAEERALLDEHSEDIESLARADRFLYEISKIPHYEQRLKSLHYKKRF 1127
            .. ||...|::.|:|..|..|:...|.:...|..||...::|...:|.:.....||.::.:|.:|
Mouse   725 ET-QLSESMIQNLIKHLPDEEQLKSLSQFRSDYNSLCEPEQFAVVMSNVKRLRPRLSAILFKLQF 788

  Fly  1128 MLTINDLVPRITSVMEASREVARSRRLRKLLELVLALGNYMNRGARGNAS--GFRLASLNRLADT 1190
            ...:|::.|.|.:|..|..|:.:|:...|||||||.:|||||.|:| ||.  ||.|:||.:|.||
Mouse   789 EEQVNNIKPDIMAVSTACEEIKKSKGFSKLLELVLLMGNYMNAGSR-NAQTFGFDLSSLCKLKDT 852

  Fly  1191 KSSAAKGTTLLHYLVQVIERKFKDLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIE 1255
            ||:..| |||||:||.|.|.|..|:|...||:.|:.:||:||:..::|:::.:...|..:.:.:|
Mouse   853 KSADQK-TTLLHFLVDVCEEKHADILHFVDDLAHLDKASRVSVEMLEKNVKQMGRQLQQLEKNLE 916

  Fly  1256 FHRSSGPAQQGDRFLPVMREFHAQASVRFAELEDKFQDMKTRFDRAVRLFGEDGSVLQPDEFFGI 1320
              ....|....|:|:..|..|...|:.::.:|......|...:...:..:..|...:..:|||..
Mouse   917 --TFPPPEDLHDKFVIKMSSFVISANEQYEKLSTLLGSMTQLYQSIMGYYAVDMKKVSVEEFFND 979

  Fly  1321 FDSFLAAFAEARHDNESFRRRQEEEEKR---AKQEAELKKRTIERKNKTGLMTSVARNLGLKSGS 1382
            .::|..:|..|..:|.. :|...|:|||   ||:.||  |..:||:.:.      .|.|.:|:
Mouse   980 LNNFRTSFMLALKENIK-KREAAEKEKRARIAKERAE--KERLERQQEK------KRLLEMKT-- 1033

  Fly  1383 SNGDPDSPAKGGDNKGEFDDLISALRTGDVFGEDMAKFKRSRKAR 1427
                      .||..|..|.|:.||::|..|.:   :.||:.|.:
Mouse  1034 ----------EGDETGVMDSLLEALQSGAAFRD---RRKRTPKLK 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:283920	47/209 (22%)
		Drf_FH3	551..737	CDD:283917	59/189 (31%)
		FliJ	779..>875	CDD:280262	13/95 (14%)
		FH2	950..1328	CDD:280362	115/380 (30%)
Diaph3	NP_062644.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:19117945	16..39
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..95		7/33 (21%)
		Drf_GBD	96..276	CDD:283920	47/208 (23%)
		Drf_FH3	284..471	CDD:283917	62/217 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..601		29/73 (40%)
		FH2	615..987	CDD:280362	115/380 (30%)
		Nuclear export signal. /evidence=ECO:0000269\|PubMed:19117945	1162..1171
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950