Protein Alignment DAAM and daam1b

DIOPT Version :10

• Sequence 1: NP_001188522.1
• Gene: DAAM / 31075
• FlyBaseID: FBgn0025641
• Length: 1463
• Species: Drosophila melanogaster
• Sequence 2: NP_001025307.1
• Gene: daam1b / 560060
• ZFINID: ZDB-GENE-030131-4212
• Length: 1079
• Species: Danio rerio
• Alignment Length: 1177
• Identity: 554/1177 - (47%)
• Similarity: 780/1177 - (66%)
• Gaps: 130/1177 - (11%)

  Fly   308 KKKMPGFRGRRVWCGCFKDDEPPEICV-VEGAFTLQTLTPTQPMPSVDELDTKFAELVEELDLTA 371
            :|:..|..|...:..||:..:.|||.. :...|.|||:.|..|:||.||||..|:|||:|||||.
Zfish     4 RKRGGGGHGASFFFCCFQSSDHPEITYRLREDFALQTMEPALPIPSYDELDAMFSELVDELDLTE 68

  Fly   372 PNKEAMLSLPAQKKWQIYCSRKLPLDAADGPDAAAVTQPPTAEHYIERLKELVVHISLSPEDSPS 436
            .::|||.:|||:||||||||:|...:...|    |.:.|   |.||::|..:....:|...:...
Zfish    69 KHREAMFALPAEKKWQIYCSKKKEQEENKG----ATSWP---EFYIDQLNSMAARKTLLALEKEE 126

  Fly   437 HELGNRLDGHAAFVDALKTALRTSTHSFVLRFVELDGLPALLDLLLQLDIRVANSPLHTSLIGCI 501
            .|..|:.      :::|||||||....||.||::||||..:|:.|..:|.....|.:||||||||
Zfish   127 EEERNKT------IESLKTALRTQPMRFVTRFIDLDGLTCILNFLKSMDYETTESQIHTSLIGCI 185

  Fly   502 KALMNNSMGRAHVLAHPTAIDTIARSLAADNIRTKIAALEILGAVCLVPGGHRKVLQAMLHFQVF 566
            |||||||.||||||:|..:|:.||:|||.|||:||:|.|||:||||||||||:|:|:||||:|.|
Zfish   186 KALMNNSQGRAHVLSHTESINIIAQSLATDNIKTKVAVLEIMGAVCLVPGGHKKILEAMLHYQKF 250

  Fly   567 ATERTRFQSIVNDLDRSTYAYRDNVNLKTALMSFVNAVLNYGPGQENLEFRLHLRYEFLMLGIQP 631
            |.||||||:::||||:||..|||.|:||||:|||:||||:.|.|:.:||||:|||||||||||||
Zfish   251 ACERTRFQTLLNDLDKSTGRYRDEVSLKTAIMSFINAVLSQGAGESSLEFRVHLRYEFLMLGIQP 315

  Fly   632 VIDKLRTHENETLDRHLDFFEMVRAEDEKEFARRFKEEHVDTKSAGSMFELLRRKLSHSPAYPHM 696
            :|||||:|||.|||||||:|||:|.:||...:|||:..|:|||||..:|||:|:||:|:.||||.
Zfish   316 IIDKLRSHENSTLDRHLDYFEMLRNDDELTLSRRFEAIHIDTKSATQVFELVRKKLAHTDAYPHF 380

  Fly   697 LSLLQHMLLLPY--TGHCTEHWLLIDRVVQQIVLQVEQRPNSDLIVDPDDPEKQLKLAAESPVHD 759
            :|:|.|.||:|:  :|:..::|||:||:|||:|||.::.                        ||
Zfish   381 MSVLHHCLLMPHKRSGNTVQYWLLLDRIVQQMVLQNDKG------------------------HD 421

  Fly   760 PDVAPLQ-IDVAKLVRLLVKEEQLTQARKRADELERENFDVQSRLAKKEQELDLRMQEKEDLETG 823
            ||..||: .:|..:||:||.|.::.|.:::|:::.:::.::|.::.|||:|.|.:.||||::...
Zfish   422 PDATPLENFNVKNVVRMLVNENEVKQWKEQAEKMRKDHHELQQKMEKKERECDAKTQEKEEMMQT 486

  Fly   824 LARMRERLEKESAQHSQAVQRAQTAEM--RAEDLQHRLISEQQERARLERLVTEGSIPDDQKVAG 886
            |.:|:|:||:|..:|....|  |.|||  |..:|..|.|:               |:|....|:|
Zfish   487 LNKMKEKLEREMGEHKLVKQ--QVAEMTTRLHELSTRQIA---------------SVPGGPPVSG 534

  Fly   887 LTGCNGAVSPPPAPP----MLKAIPPPPPPMAPSMMPPPPPPCPGAPPPPPSMAQ-TMAPAPPKV 946
            ..|  |.:.|||.||    |:.  ||||||...:||||||||.||.|||||.... ..||.||..
Zfish   535 PLG--GPLLPPPPPPPPGGMMP--PPPPPPPCGAMMPPPPPPPPGGPPPPPGRPPFGSAPPPPGA 595

  Fly   947 ----DLPKKNVPQPTNPLKSFNWSKLPDAKLQGTVWSELDESKLYNNMELESIDKLFSAYQK--- 1004
                .|.|||:|||:||||||||:||.:.||:||||:::|:.:::..::||.|:|.|||||:
Zfish   596 PIGPSLKKKNIPQPSNPLKSFNWAKLSENKLEGTVWADVDDGRVFKILDLEDIEKTFSAYQRQQD 660

  Fly  1005 ------NGVSATDGSYEDLRVTGKAAKQKVLSVIDGRRAQNCTILLSKLKMSDMEISKAILSMDS 1063
                  |....|    ||..::.|  |.|.||||||||||||.||||:||:|:.||.:|||:||.
Zfish   661 FFMVNNNKQKET----EDDTLSSK--KVKELSVIDGRRAQNCNILLSRLKLSNEEIKRAILTMDE 719

  Fly  1064 NEQLQLDMVEQLLKFTPSAEERALLDEHSEDIESLARADRFLYEISKIPHYEQRLKSLHYKKRFM 1128
            .|.|..||:||:|||.|...:..||:||..:::.:|:|||||||:|:|.||:|||:||::||:|.
Zfish   720 QEDLPKDMLEQMLKFVPEKSDVDLLEEHKHELDRMAKADRFLYEMSRINHYQQRLQSLYFKKKFA 784

  Fly  1129 LTINDLVPRITSVMEASREVARSRRLRKLLELVLALGNYMNRGARGNASGFRLASLNRLADTKSS 1193
            ..|.::.|::.::.:||:||..||..::|||:|||.|||||:|.||||.||:::|||::||||||
Zfish   785 ERIAEIKPKVEALTKASKEVLHSRNFKQLLEVVLAFGNYMNKGQRGNAYGFKISSLNKIADTKSS 849

  Fly  1194 AAKGTTLLHYLVQVIERKFKDLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEFHR 1258
            ..|..||||||:.::|:|:..::..::::.:|.||:||::.|::|:|..||:||..|..|::|.:
Zfish   850 IDKNITLLHYLITILEKKYSKVMLFQEELKNVPEAAKVNMTELEKEINNLRSGLKSVESELDFQK 914

  Fly  1259 SSGPAQQGDRFLPVMREFHAQASVRFAELEDKFQDMKTRFDRAVRLFGEDGSVLQPDEFFGIFDS 1323
            .. |.:.||:|:.|:.:|...||..|:::||...:.|..|.:.|:.||||...:||||||||||.
Zfish   915 KR-PQEYGDKFVSVVSQFITVASFSFSDVEDSLCEAKELFIKTVKHFGEDADKMQPDEFFGIFDQ 978

  Fly  1324 FLAAFAEARHDNESFRRRQEEEEKRAKQEAELK-KRTIERKNKTGLMTSVARNLGLKSGSSNGDP 1387
            ||.:|||||.:||:.|||:||||:||:.||:|| :|..|||              .:....||:
Zfish   979 FLQSFAEARQENENIRRRKEEEERRARMEAQLKEQREKERK--------------ARKAKENGE- 1028

  Fly  1388 DSPAKGGDNKGEFDDLISALRTGDVFGEDMAKFKRSRKARVLNGGGSSTGHTSPPRHGSLQREES 1452
                   |:.||||||:||||:|:||.:|::|.||:|| |:                 :.|..:|
Zfish  1029 -------DDGGEFDDLVSALRSGEVFDKDLSKMKRNRK-RI-----------------NSQTSDS 1068

  Fly  1453 GRERERT 1459
            ||||..|
Zfish  1069 GRERPIT 1075

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:461886	100/198 (51%)
		Drf_FH3	551..737	CDD:461885	117/187 (63%)
		Smc	<765..>875	CDD:440809	35/112 (31%)
		FH2	950..1328	CDD:396655	188/386 (49%)
daam1b	NP_001025307.1	Drf_GBD	45..232	CDD:461886	100/199 (50%)
		Drf_FH3	235..439	CDD:461885	126/227 (56%)
		FH2	603..983	CDD:396655	188/386 (49%)