Protein Alignment DAAM and diaph2

DIOPT Version :10

• Sequence 1: NP_001188522.1
• Gene: DAAM / 31075
• FlyBaseID: FBgn0025641
• Length: 1463
• Species: Drosophila melanogaster
• Sequence 2: XP_021336921.1
• Gene: diaph2 / 556029
• ZFINID: ZDB-GENE-090115-1
• Length: 1166
• Species: Danio rerio
• Alignment Length: 1269
• Identity: 350/1269 - (27%)
• Similarity: 552/1269 - (43%)
• Gaps: 238/1269 - (18%)

  Fly   275 GSSNTNGLGLRKWLSGNTSSNETPLQKHYR---HQQKKKMPGFRGRRVWCGCFKDDEPPEICVVE 336
            |..:.|....:|  |....|....|..|.:   ...:.::..||.:    |..|  |.|.|....
Zfish     7 GGEDPNKPSKKK--SSEDESKNKKLNIHIKTLADDMRDRITSFRKQ----GMKK--EKPLIQHPT 63

  Fly   337 GAFTLQTLTPTQPMPSVDE----LDTK-----FAELVEELDLTAPNKEAMLSLPAQKKWQIYCSR 392
            ...:.||..|. |.|..||    |..|     |.:::|:::|   |:|                |
Zfish    64 DPISTQTELPV-PQPFFDERSMNLSEKEIVDLFEKMMEDMNL---NEE----------------R 108

  Fly   393 KLPLDAADGPDAAAVTQPPTAEHYIERLKELVV-------------HISLSPEDSPSHEL--GNR 442
            |.||...|     ..|:......||....:.:.             ..:||.::. .|||  |..
Zfish   109 KAPLRGKD-----LSTKREMVVQYISATAKSITGSKVAGGLRNSKHECTLSSQEY-VHELRSGIS 167

  Fly   443 LDGHAAFVDALKTALRTSTHSFVLRF------VELDGLPALLDLLLQLDIRVANSPLHTSLIGCI 501
            .|.....:::|:.:|.::..|:|..|      :.||.|..|||...|.:|...|.  | .||.|:
Zfish   168 EDKLLNCLESLRVSLTSNPVSWVNNFGHEGLGLLLDALERLLDKKQQENIDKKNQ--H-KLIQCL 229

  Fly   502 KALMNNSMGRAHVLAHPTAIDTIARSL--AADNIRTKIAALEILGAVCLVPGGHRKVLQAMLHFQ 564
            ||.|||..|...:|....::..:||::  ...|:.|:|  ::||.|||::  |...:|..:|...
Zfish   230 KAFMNNKYGLQRILGDERSLLLLARAIDPKQTNMMTEI--VKILSAVCII--GEENILDKILAAM 290

  Fly   565 VFATERT---RFQSIVNDLDRSTYAYRDNVNLKTALMSFVNAVLNYGPGQENLEFRLHLRYEFLM 626
            ..|.||.   ||..||..|:.     .:...|:.|.|..:||::.   ..::|:||:|||.|||.
Zfish   291 TIAAERNNKERFAPIVEGLEN-----HEAQQLQVACMQLINALVT---SPDDLDFRIHLRNEFLR 347

  Fly   627 LGIQPVIDKLRTHENETLDRHLDFFEMVRAEDEKEFARRFKEEHVDTKSAGSMFELLRRKLSHSP 691
            .|::.::.:|:  |.|.||..|..|...:.||..|.:.|..:...:....|.::.||...:..:.
Zfish   348 CGLKKILPELK--ETEELDIQLKVFNENKEEDSIELSHRLDDIRAEMDDMGEVYHLLSNMVKDTG 410

  Fly   692 AYPHMLSLLQHMLLLPYTGHC-TEHWLLIDRVVQQIVLQVEQRPNSDLIVDPDDPEKQLKLAAES 755
            :.|:.||:|||:||:....:. .:::.:|:..|.||||.     .|.:
Zfish   411 SEPYFLSILQHLLLIRNDYYIRPQYYKVIEECVSQIVLH-----RSGM----------------- 453

  Fly   756 PVHDPDVA---PLQIDVAKLVRLLVKEEQLTQARKRADELERENFDVQSRLAKKEQELDLRMQEK 817
               |||.|   .|.:|.:.|:...|.:.::.::.:||.|..:: || :...|::|.:.:|:.||
Zfish   454 ---DPDFAYRERLDVDFSHLIDQCVDKAKVDESEQRAAEFSKK-FD-EEFSARQEAQAELQKQE- 512

  Fly   818 EDLETGLARMRERLEKESAQHSQAVQRAQTAEMRAEDLQHRLISEQQERARLERLVTE--GSIPD 880
                          ||..|..||           ...||.:|.||:.:....|:.::|  ..|..
Zfish   513 --------------EKIKAFESQ-----------INTLQAQLTSERDKLKEAEKSISERNSKIAA 552

  Fly   881 DQKVAGL----------------------TGCNGAVSPPPAPPMLKAIPPPPPPMAPSMMPPPPP 923
            ..|.||.                      ....||..|||.||...::.|||||..|...|||||
Zfish   553 GPKAAGAGPPPPPPPPGGIAPPPPPPPPPPPIGGAPPPPPPPPFPASLGPPPPPPPPGCGPPPPP 617

  Fly   924 PCP-GAPPPPPSMAQTMAPAPPKVDLP----KKNVPQPTNPLKSFNWSKL-PDAKLQGTVWSELD 982
            |.| |.|||||.|..  ||.|..|.||    .|...:|.:.:|..||||: |....:...|.::.
Zfish   618 PPPGGGPPPPPGMPS--APPPLVVQLPYGLAPKKTYKPDSIMKRVNWSKIVPQEMAENCFWLKVK 680

  Fly   983 ESKLYNNMELESIDKLFSAYQ--KNGVSATDGSYEDLRVTGKAAKQKVLSVIDGRRAQNCTILLS 1045
            |.:..|......:...||:..  |..|..||.     |:|....|.|.|.::|.:.|||.:|.|.
Zfish   681 EERFENTDMFSELSLSFSSKSRVKKDVEETDD-----RMTQFKKKAKELRILDAKTAQNLSIFLG 740

  Fly  1046 KLKMSDMEISKAILSMDSNEQLQLDMVEQLLKFTPSAEERALLDEHSEDIESLARADRFLYEISK 1110
            ..::...||...:|.:| .|:|...:::.|:|..|..:|.:.|.|...:.|.|..:::|...:|.
Zfish   741 SFRLPYEEIRDIVLQVD-EERLSEALIQNLIKNLPEQKELSNLAELKNEYEELCESEQFGIVMSS 804

  Fly  1111 IPHYEQRLKSLHYKKRFMLTINDLVPRITSVMEASREVARSRRLRKLLELVLALGNYMNRGARGN 1175
            :.....||..:.:|..|...:|::.|.|.:|..|..||.:|.....|||:||.:|||||.|:| |
Zfish   805 VKMLRPRLNGILFKLTFEEQVNNIRPDIMNVTFACEEVKKSEGFHMLLEMVLLVGNYMNSGSR-N 868

  Fly  1176 AS--GFRLASLNRLADTKSSAAKGTTLLHYLVQVIERKFKDLLKLEDDIPHVREASKV------- 1231
            |.  ||.::.|.:|.||||: .:.|||||:|.:..|.|:.::||..|::.||..||||
Zfish   869 AQTFGFNISFLCKLRDTKST-DQNTTLLHFLAEKCEEKYPEMLKFPDELEHVESASKVAAQTLKA 932

  Fly  1232 SLGEMDKDIQMLRTGLADVAREIEFHRSSGPAQQGDRFLPVMREFHAQASVRFAELEDKFQDMKT 1296
            ||..|::.||.|...:.:..:..:         :.|:|:..|..|...:..::.:|....::|:.
Zfish   933 SLDIMERHIQRLENDIQNFPKTDD---------KQDKFVEKMSGFSKHSREQYEKLSTMHKNMQK 988

  Fly  1297 RFDRAVRLFGEDGSVLQPDEFFGIFDSFLAAFAEARHDNESFRRRQEEEEKR---AKQEAELKKR 1358
            .::.....|..|...:..::|||...:|...|.:|..:|.. :|..||:.||   ||::||.:|
Zfish   989 LYENLGSYFAFDPHTVSIEDFFGDLANFRNLFMDAVRENHK-KREMEEKIKRAKIAKEKAEREK- 1051

  Fly  1359 TIERKNKTGLMTSVARNLGLKSGSSNGDPDSPAKGGDNKGEFDDLISALRTGDVFGEDMAKFKRS 1423
             |||:.|...:..:                  .|.||..|..|.|:.||::|..|        |.
Zfish  1052 -IERQQKKKQLIDM------------------NKEGDETGVMDSLMEALQSGAAF--------RD 1089

  Fly  1424 RKARVLNGGGSSTGHTSPPRHGSLQREESGRERE 1457
            |:.|....|..|...::|...|:.....||:.|:
Zfish  1090 RRKRTPRNGDQSPSCSAPRWPGANHDAASGKSRQ 1123

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:461886	60/230 (26%)
		Drf_FH3	551..737	CDD:461885	54/189 (29%)
		Smc	<765..>875	CDD:440809	25/109 (23%)
		FH2	950..1328	CDD:396655	113/389 (29%)
diaph2	XP_021336921.1	Drf_GBD	86..276	CDD:461886	56/219 (26%)
		Drf_FH3	284..470	CDD:461885	59/220 (27%)
		EnvC	477..>545	CDD:443969	21/95 (22%)
		FH2	647..1020	CDD:396655	113/389 (29%)