DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAAM and diaph2

DIOPT Version :9

Sequence 1:	NP_001188522.1	Gene:	DAAM / 31075	FlyBaseID:	FBgn0025641	Length:	1463	Species:	Drosophila melanogaster
Sequence 2:	XP_021336921.1	Gene:	diaph2 / 556029	ZFINID:	ZDB-GENE-090115-1	Length:	1166	Species:	Danio rerio

Alignment Length:	1269	Identity:	350/1269 - (27%)
Similarity:	552/1269 - (43%)	Gaps:	238/1269 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   275 GSSNTNGLGLRKWLSGNTSSNETPLQKHYR---HQQKKKMPGFRGRRVWCGCFKDDEPPEICVVE 336
            |..:.|....:|  |....|....|..|.:   ...:.::..||.:    |..|  |.|.|....
Zfish     7 GGEDPNKPSKKK--SSEDESKNKKLNIHIKTLADDMRDRITSFRKQ----GMKK--EKPLIQHPT 63

  Fly   337 GAFTLQTLTPTQPMPSVDE----LDTK-----FAELVEELDLTAPNKEAMLSLPAQKKWQIYCSR 392
            ...:.||..|. |.|..||    |..|     |.:::|:::|   |:|                |
Zfish    64 DPISTQTELPV-PQPFFDERSMNLSEKEIVDLFEKMMEDMNL---NEE----------------R 108

  Fly   393 KLPLDAADGPDAAAVTQPPTAEHYIERLKELVV-------------HISLSPEDSPSHEL--GNR 442
            |.||...|     ..|:......||....:.:.             ..:||.::. .|||  |..
Zfish   109 KAPLRGKD-----LSTKREMVVQYISATAKSITGSKVAGGLRNSKHECTLSSQEY-VHELRSGIS 167

  Fly   443 LDGHAAFVDALKTALRTSTHSFVLRF------VELDGLPALLDLLLQLDIRVANSPLHTSLIGCI 501
            .|.....:::|:.:|.::..|:|..|      :.||.|..|||...|.:|...|.  | .||.|:
Zfish   168 EDKLLNCLESLRVSLTSNPVSWVNNFGHEGLGLLLDALERLLDKKQQENIDKKNQ--H-KLIQCL 229

  Fly   502 KALMNNSMGRAHVLAHPTAIDTIARSL--AADNIRTKIAALEILGAVCLVPGGHRKVLQAMLHFQ 564
            ||.|||..|...:|....::..:||::  ...|:.|:|  ::||.|||::  |...:|..:|...
Zfish   230 KAFMNNKYGLQRILGDERSLLLLARAIDPKQTNMMTEI--VKILSAVCII--GEENILDKILAAM 290

  Fly   565 VFATERT---RFQSIVNDLDRSTYAYRDNVNLKTALMSFVNAVLNYGPGQENLEFRLHLRYEFLM 626
            ..|.||.   ||..||..|:.     .:...|:.|.|..:||::.   ..::|:||:|||.|||.
Zfish   291 TIAAERNNKERFAPIVEGLEN-----HEAQQLQVACMQLINALVT---SPDDLDFRIHLRNEFLR 347

  Fly   627 LGIQPVIDKLRTHENETLDRHLDFFEMVRAEDEKEFARRFKEEHVDTKSAGSMFELLRRKLSHSP 691
            .|::.::.:|:  |.|.||..|..|...:.||..|.:.|..:...:....|.::.||...:..:.
Zfish   348 CGLKKILPELK--ETEELDIQLKVFNENKEEDSIELSHRLDDIRAEMDDMGEVYHLLSNMVKDTG 410

  Fly   692 AYPHMLSLLQHMLLLPYTGHC-TEHWLLIDRVVQQIVLQVEQRPNSDLIVDPDDPEKQLKLAAES 755
            :.|:.||:|||:||:....:. .:::.:|:..|.||||.     .|.:
Zfish   411 SEPYFLSILQHLLLIRNDYYIRPQYYKVIEECVSQIVLH-----RSGM----------------- 453

  Fly   756 PVHDPDVA---PLQIDVAKLVRLLVKEEQLTQARKRADELERENFDVQSRLAKKEQELDLRMQEK 817
               |||.|   .|.:|.:.|:...|.:.::.::.:||.|..:: || :...|::|.:.:|:.||
Zfish   454 ---DPDFAYRERLDVDFSHLIDQCVDKAKVDESEQRAAEFSKK-FD-EEFSARQEAQAELQKQE- 512

  Fly   818 EDLETGLARMRERLEKESAQHSQAVQRAQTAEMRAEDLQHRLISEQQERARLERLVTE--GSIPD 880
                          ||..|..||           ...||.:|.||:.:....|:.::|  ..|..
Zfish   513 --------------EKIKAFESQ-----------INTLQAQLTSERDKLKEAEKSISERNSKIAA 552

  Fly   881 DQKVAGL----------------------TGCNGAVSPPPAPPMLKAIPPPPPPMAPSMMPPPPP 923
            ..|.||.                      ....||..|||.||...::.|||||..|...|||||
Zfish   553 GPKAAGAGPPPPPPPPGGIAPPPPPPPPPPPIGGAPPPPPPPPFPASLGPPPPPPPPGCGPPPPP 617

  Fly   924 PCP-GAPPPPPSMAQTMAPAPPKVDLP----KKNVPQPTNPLKSFNWSKL-PDAKLQGTVWSELD 982
            |.| |.|||||.|..  ||.|..|.||    .|...:|.:.:|..||||: |....:...|.::.
Zfish   618 PPPGGGPPPPPGMPS--APPPLVVQLPYGLAPKKTYKPDSIMKRVNWSKIVPQEMAENCFWLKVK 680

  Fly   983 ESKLYNNMELESIDKLFSAYQ--KNGVSATDGSYEDLRVTGKAAKQKVLSVIDGRRAQNCTILLS 1045
            |.:..|......:...||:..  |..|..||.     |:|....|.|.|.::|.:.|||.:|.|.
Zfish   681 EERFENTDMFSELSLSFSSKSRVKKDVEETDD-----RMTQFKKKAKELRILDAKTAQNLSIFLG 740

  Fly  1046 KLKMSDMEISKAILSMDSNEQLQLDMVEQLLKFTPSAEERALLDEHSEDIESLARADRFLYEISK 1110
            ..::...||...:|.:| .|:|...:::.|:|..|..:|.:.|.|...:.|.|..:::|...:|.
Zfish   741 SFRLPYEEIRDIVLQVD-EERLSEALIQNLIKNLPEQKELSNLAELKNEYEELCESEQFGIVMSS 804

  Fly  1111 IPHYEQRLKSLHYKKRFMLTINDLVPRITSVMEASREVARSRRLRKLLELVLALGNYMNRGARGN 1175
            :.....||..:.:|..|...:|::.|.|.:|..|..||.:|.....|||:||.:|||||.|:| |
Zfish   805 VKMLRPRLNGILFKLTFEEQVNNIRPDIMNVTFACEEVKKSEGFHMLLEMVLLVGNYMNSGSR-N 868

  Fly  1176 AS--GFRLASLNRLADTKSSAAKGTTLLHYLVQVIERKFKDLLKLEDDIPHVREASKV------- 1231
            |.  ||.::.|.:|.||||: .:.|||||:|.:..|.|:.::||..|::.||..||||
Zfish   869 AQTFGFNISFLCKLRDTKST-DQNTTLLHFLAEKCEEKYPEMLKFPDELEHVESASKVAAQTLKA 932

  Fly  1232 SLGEMDKDIQMLRTGLADVAREIEFHRSSGPAQQGDRFLPVMREFHAQASVRFAELEDKFQDMKT 1296
            ||..|::.||.|...:.:..:..:         :.|:|:..|..|...:..::.:|....::|:.
Zfish   933 SLDIMERHIQRLENDIQNFPKTDD---------KQDKFVEKMSGFSKHSREQYEKLSTMHKNMQK 988

  Fly  1297 RFDRAVRLFGEDGSVLQPDEFFGIFDSFLAAFAEARHDNESFRRRQEEEEKR---AKQEAELKKR 1358
            .::.....|..|...:..::|||...:|...|.:|..:|.. :|..||:.||   ||::||.:|
Zfish   989 LYENLGSYFAFDPHTVSIEDFFGDLANFRNLFMDAVRENHK-KREMEEKIKRAKIAKEKAEREK- 1051

  Fly  1359 TIERKNKTGLMTSVARNLGLKSGSSNGDPDSPAKGGDNKGEFDDLISALRTGDVFGEDMAKFKRS 1423
             |||:.|...:..:                  .|.||..|..|.|:.||::|..|        |.
Zfish  1052 -IERQQKKKQLIDM------------------NKEGDETGVMDSLMEALQSGAAF--------RD 1089

  Fly  1424 RKARVLNGGGSSTGHTSPPRHGSLQREESGRERE 1457
            |:.|....|..|...::|...|:.....||:.|:
Zfish  1090 RRKRTPRNGDQSPSCSAPRWPGANHDAASGKSRQ 1123

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:283920	60/230 (26%)
		Drf_FH3	551..737	CDD:283917	54/189 (29%)
		FliJ	779..>875	CDD:280262	21/95 (22%)
		FH2	950..1328	CDD:280362	113/389 (29%)
diaph2	XP_021336921.1	Drf_GBD	86..276	CDD:310750	56/219 (26%)
		Drf_FH3	284..470	CDD:310747	59/220 (27%)
		FH2	647..1020	CDD:280362	113/389 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.950