DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAAM and Diaph2

DIOPT Version :9

Sequence 1:	NP_001188522.1	Gene:	DAAM / 31075	FlyBaseID:	FBgn0025641	Length:	1463	Species:	Drosophila melanogaster
Sequence 2:	XP_006528644.1	Gene:	Diaph2 / 54004	MGIID:	1858500	Length:	1109	Species:	Mus musculus

Alignment Length:	1258	Identity:	335/1258 - (26%)
Similarity:	557/1258 - (44%)	Gaps:	234/1258 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 GSGNCNSNCNGSSNTNGLGLRKWLSGNTSSNETPLQ---------KHYRHQQKKKMPGFRGRRVW 320
            |.|....:..|.||..|       :||.::||...:         |......:.::..||.
Mouse    14 GGGGGEEHGGGRSNKRG-------AGNRAANEEETRNKPKLNIQIKTLADDVRDRITSFRK---- 67

  Fly   321 CGCFKDDEPPEICVVEGAFTLQTLTPTQP-----------MPSVDELDTKFAELVEELDLTAPNK 374
             ...|.::|    |::.:...||.....|           :.|..|:...|.:::|:::|....|
Mouse    68 -SATKREKP----VIQHSIDYQTAVVEIPPALIVHDDRSLILSEKEVLDLFEKMMEDMNLNEEKK 127

  Fly   375 EAMLSLPAQKKWQIYCSRKLPLDAADGPDAAAVTQPPTAEHYIERLKELVVHISLSPEDSPSHEL 439
                 .|.:|| .....|::.:..     .:|.::.......:..||......:||.::. .|||
Mouse   128 -----APLRKK-DFSIKREMVVQY-----ISATSKSIVGSKVLGGLKNSKHEFTLSSQEY-VHEL 180

  Fly   440 GNRLDGHAAF--VDALKTALRTSTHSFVLRF------VELDGLPALLDLLLQLDIRVANSPLHTS 496
            .:.:......  :::|:.:|.:...|:|..|      |.||.|..|||...|.:|...|   ...
Mouse   181 RSGISDEKLLNCLESLRVSLTSHPVSWVNNFGYEGLGVLLDVLEKLLDKKQQENIDKKN---QYK 242

  Fly   497 LIGCIKALMNNSMGRAHVLAHPTAIDTIARSL--AADNIRTKIAALEILGAVCLVPGGHRKVLQA 559
            :|.|:||.|||..|...:|....::..:||::  ...|:.|:|  ::||.|:|:|  |...:|..
Mouse   243 VIQCLKAFMNNKFGLQRILGDERSLLLLARAIDPKQQNMMTEI--VKILSAICIV--GEENILDK 303

  Fly   560 MLHFQVFATE---RTRFQSIVNDLDRSTYAYRDNVNLKTALMSFVNAVLNYGPGQENLEFRLHLR 621
            :|.....|.|   |.||..||..|:.:     :.::|:.|.|.|:||::.   ...:|:||:|||
Mouse   304 LLGGITAAAELNNRERFSPIVEGLENN-----EALHLQVACMQFINALVT---SPYDLDFRIHLR 360

  Fly   622 YEFLMLGIQPVIDKLRTHENETLDRHLDFFEMVRAEDEKEFARRFKEEHVDTKSAGSMFELLRRK 686
            .|||..|::.::..|:..|||.||..|..||..:.:|..|.:.|..:...:......::.||...
Mouse   361 NEFLRCGLKAMLPTLKEIENEGLDIQLRVFEENKEDDLSELSHRLNDIRAEMDDINEVYHLLYNM 425

  Fly   687 LSHSPAYPHMLSLLQHMLLLPYTGHC-TEHWLLIDRVVQQIVLQVEQRPNSDLIVDPDDPEKQLK 750
            |..:.|.|::||:|||.||:....:. .:::.:|:..|.||||....       :|||...:|
Mouse   426 LKDTAAEPYLLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSG-------MDPDFKYRQ-- 481

  Fly   751 LAAESPVHDPDVAPLQIDVAKLVRLLVKEEQLTQARKRADELERENFDVQSRLAKKEQ-ELDLRM 814
                         .:..|...|:...|.:.::.:..::|.|..:: ||.:....::.| ||..|.
Mouse   482 -------------RIDFDFTHLLDACVNKAKVEENEQKAMEFSKK-FDEEFTARQEAQAELQKRD 532

  Fly   815 QEKEDLETGLARMRERLEKESAQHSQAVQRAQTAEMRAEDLQHRLISEQQERARLERLVTEGSIP 879
            ::.::|||.:.::|          .|.|..|                                ||
Mouse   533 EKIKELETEIQQLR----------GQGVPSA--------------------------------IP 555

  Fly   880 DDQKVAGLTGCNGAVSPPPAPPMLKAIPPPPPPMAPSMMPPPPPPCPG----APPPPPSMAQTMA 940
            .......|.|....  |||.||     ||||||: |.::||||||.||    .|||||.::....
Mouse   556 GPPPPPPLPGAGPC--PPPPPP-----PPPPPPL-PGVVPPPPPPLPGMPGIPPPPPPPLSGVPP 612

  Fly   941 PAPP----------KVDLP----KKNVPQPTNPLKSFNWSKLPDAKL-QGTVWSELDESKLYNNM 990
            |.||          .::||    :|.:.:|..|:|..||||:...:| :..||.:|.|.| |.|.
Mouse   613 PPPPPGGVFPLLSGPIELPYGMKQKKLYKPDIPMKRINWSKIEPKELSENCVWLKLKEEK-YENA 676

  Fly   991 ELESIDKLFSAYQKNGVSATDGSYEDLRVTGKAAKQKVLSVIDGRRAQNCTILLSKLKMSDMEIS 1055
            :|.:...|....|..|...|:.: |:.|......|.|.|.::|.:.|||.:|.|...:|...||.
Mouse   677 DLFAKLALTFPSQMKGQRNTEAA-EENRSGPPKKKVKELRILDTKTAQNLSIFLGSYRMPYEEIK 740

  Fly  1056 KAILSMDSNEQLQLDMVEQLLKFTPSAEERALLDEHSEDIESLARADRFLYEISKIPHYEQRLKS 1120
            ..||.: :.|.|...:::.|:|:.|.......|.:...:.:.|...::|...:|.:.....||.|
Mouse   741 NIILEV-NEEMLSEALIQNLVKYLPDQNALRELAQLKSEYDDLCEPEQFGVVMSTVKMLRPRLTS 804

  Fly  1121 LHYKKRFMLTINDLVPRITSVMEASREVARSRRLRKLLELVLALGNYMNRGARGNAS-GFRLASL 1184
            :.:|..|...:|::.|.|.:|..|..|:.:|...::||||:|.:|||||.|:|...| ||::..|
Mouse   805 ILFKLTFEEHVNNIKPSIIAVTLACEELKKSESFKRLLELILLVGNYMNSGSRNAQSLGFKINFL 869

  Fly  1185 NRLADTKSSAAKGTTLLHYLVQVIERKFKDLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLAD 1249
            .::.||||:..| :||||:|.::.:.|::|:||..|::.||..|.|||       .|:|::.|..
Mouse   870 CKIKDTKSADQK-STLLHFLAEICDEKYRDILKFPDELEHVESAGKVS-------AQILKSNLVA 926

  Fly  1250 VAREIEFH-----RSSGPAQ-QGDRFLPVMREFHAQASVRFAELEDKFQDMKTRFDRAVRLFGED 1308
            :.:.| .|     ::..||: ..|:|:..|..|...|..::.:|.....:|...::.....|..|
Mouse   927 MEQSI-LHLEKNIKNFPPAESHHDKFVEKMMSFTQNAREQYDKLSTMHSNMLKLYESLGEYFIFD 990

  Fly  1309 GSVLQPDEFFGIFDSFLAAFAEARHDNESFRRRQEEEEKR---AKQEAELKKRTIERKNKTGLMT 1370
            .:.:..:||||..::|...|.||..:|.. |:..||:.:|   ||::||.:|  :||:.|...:.
Mouse   991 PNTVNMEEFFGDLNTFRTLFLEALKENHK-RKEMEEKSRRAKLAKEKAEQEK--LERQKKKKQLI 1052

  Fly  1371 SVARNLGLKSGSSNGDPDSPAKGGDNKGEFDDLISALRTGDVFGEDMAKFKRSRKARVLNGGGSS 1435
            .:                  .|.||..|..|:|:.||::|..|        |.|:.|:
Mouse  1053 DI------------------NKEGDETGVMDNLLEALQSGAAF--------RDRRKRI------- 1084

  Fly  1436 TGHTSPPRHGSLQREESGRERER 1458
                  ||:...:|....|.|.|
Mouse  1085 ------PRNPDNRRPPLERSRSR 1101

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:283920	51/219 (23%)
		Drf_FH3	551..737	CDD:283917	57/189 (30%)
		FliJ	779..>875	CDD:280262	15/96 (16%)
		FH2	950..1328	CDD:280362	116/385 (30%)
Diaph2	XP_006528644.1	Drf_GBD	104..294	CDD:368864	50/206 (24%)
		Drf_FH3	302..490	CDD:368862	60/217 (28%)
		FH2	637..1072	CDD:214697	139/467 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950