Protein Alignment DAAM and Fmnl2

DIOPT Version :10

• Sequence 1: NP_001188522.1
• Gene: DAAM / 31075
• FlyBaseID: FBgn0025641
• Length: 1463
• Species: Drosophila melanogaster
• Sequence 2: XP_038962712.1
• Gene: Fmnl2 / 499797
• RGDID: 1560248
• Length: 1098
• Species: Rattus norvegicus
• Alignment Length: 1254
• Identity: 316/1254 - (25%)
• Similarity: 524/1254 - (41%)
• Gaps: 353/1254 - (28%)

  Fly   349 PMPSVDELDTKFAELVEELDLTAPNKEAML-SLPAQKKWQIYCSRKLPLDAADGPDAAAVTQPPT 412
            |||...||:.:||.::..::| .|:|..:| ....:|||::.|.:          :...|..||
  Rat    24 PMPEPGELEERFAIVLNAMNL-PPDKARLLRQYDNEKKWELICDQ----------ERFQVKNPP- 76

  Fly   413 AEHYIERLKELVVHISLSPEDSPSHELGNRLDGHAAFVDALKTALRTSTHSFVLRFV--ELDGLP 475
             ..||::||..     |.|..: ..:...|:......:..|:.:|||:...:|..|:  |..||.
  Rat    77 -HTYIQKLKGY-----LDPAVT-RKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENKGLD 134

  Fly   476 ALLDLL------LQLDIR------------------------------------VANSPLHTSL- 497
            .|::.|      :..|..                                    |:.|..|::|
  Rat   135 VLVEYLSFAQYAVTFDFESVESTVESTVDKSKPWSRSIEDLHRGNNLPSPVGNSVSRSGRHSALR 199

  Fly   498 -------------------------IGCIKALMNNSMGRAHVLAHPTAIDTIARSLAADNIRTKI 537
                                     |.|::|:||...|...|::||.|::.||.||...|.|||.
  Rat   200 YNTLPSRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKA 264

  Fly   538 AALEILGAVCLVPGGHRKVLQAMLHFQVFATERTRFQSIVNDLDRSTYAYRDNVNLKTALMSFVN 602
            ..||:|.|||||.|||..:|.|..:|:....|:.||:.::.......    :|::...|.|.|:|
  Rat   265 LVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFEKLMEHFRNED----NNIDFMVASMQFIN 325

  Fly   603 AVLNYGPGQENLEFRLHLRYEFLMLGIQPVIDKLRTHENETLDRHLDFFEMVRAEDEKEFARRFK 667
            .|::   ..|::.||:||:|||..||:...:|||:..|::.|.      ..::|..:..|.....
  Rat   326 IVVH---SVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQ------VQIQAYLDNVFDVGAL 381

  Fly   668 EEHVDTKSAG-SMFELLRRKLSHSPAYPHMLSLLQHMLLLPYTGHCTEHWLLIDRVVQQIVLQVE 731
            .|..:||:|. ...|.|...:||                            |.:::
  Rat   382 LEDAETKNAALERVEELEENISH----------------------------LSEKL--------- 409

  Fly   732 QRPNSDLIVDPDDPEKQLKLAAESPVHDPDVAPLQIDVAKLVRLLVKEEQLTQARKRADELEREN 796
                       .|.|.:.                   ::|:|.|   |:||.|..|
  Rat   410 -----------QDTENEA-------------------MSKIVEL---EKQLMQRNK--------- 432

  Fly   797 FDVQSRLAKKEQELDLRMQEKEDLETGLARMRERL-EKESAQHSQAVQRAQTAEMRAEDLQHRLI 860
                        |||:..:..:|..|.:..:|:.: |||     :|:||..|.|.:..:|
  Rat   433 ------------ELDVVREIYKDANTQVHTLRKMVKEKE-----EAIQRQSTLEKKIHEL----- 475

  Fly   861 SEQQERARLER----------LVTEGSIPDDQKVAG---LTGCNGAVSPPPAPPMLKAIPPPP-- 910
             |:|...::::          :|..|::|....:||   :....||.|..|:.|     ||||
  Rat   476 -EKQGTIKIQKKGDGDIAILPVVASGTLPMGSDLAGGNYVGPVPGAASSGPSVP-----PPPPLP 534

  Fly   911 ---------------PPMAPSMMPPPPPPCPGAPPPP-PSMAQTMAPAPPKVDLPKKNVP----- 954
                           |||:|...||||||.|..|||| |..|....||||....|..:.|
  Rat   535 PSSDTPEAAQNGPASPPMSPPPPPPPPPPPPPPPPPPLPGPAAETVPAPPLPPPPPPSAPPLPGT 599

  Fly   955 -QPT--------------------NPLKS------FNWSKLPDAKLQGTVWSELDESKLYNNMEL 992
             .||                    .|:|:      |||..|...::.|||::|:|:.::..::.:
  Rat   600 SSPTVVFNSGLADGPIKLFSVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNV 664

  Fly   993 ESIDKLFSAYQKNGVSATDGSYEDLRVTGKAAKQKVLSVIDGRRAQNCTILLSKLKMSDMEISKA 1057
            :..:::|..  |....|.|.|....::|.|.:.:  :::::..||:|..|.|.|...|..||.||
  Rat   665 DEFEEIFKT--KAQGPAIDLSSSKQKITQKGSSK--VTLLEANRAKNLAITLRKAGKSADEICKA 725

  Fly  1058 ILSMDSNEQLQLDMVEQLLKFTPSAEERALL---DEHSEDIESLARADRFLYEISKIPHYEQRLK 1119
            |...|. :.|.:|.||.|::|.|:..|..:|   :...:.:|:|:..|||:.:.|||....|::.
  Rat   726 IHVFDL-KTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLMQKMT 789

  Fly  1120 SLHYKKRFMLTINDLVPRITSVMEASREVARSRRLRKLLELVLALGNYMNRGARGNASGFRLASL 1184
            .:.:...|..:|..|.|::.:::.||..:..|::|:|:||::||||||||...||...||:|.||
  Rat   790 IMAFIGNFTESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSL 854

  Fly  1185 NRLADTKSSAAKGTTLLHYLVQVIERKFKDLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLAD 1249
            :.|.||||:..| .|||||:..|::.|::.:....:::.:|.:|:.|||..:..|::.|:.|:..
  Rat   855 DLLLDTKSTDRK-QTLLHYISNVVKEKYQQVTLFYNELHYVEKAAAVSLENVLLDVKELQRGMDL 918

  Fly  1250 VAREIEFHRSSGPAQQGDRFLPVMREFHAQASVRFAELEDKFQDMKTRFDRAVRLFGEDGSVLQP 1314
            ..||...|..:          .:::||......:..:|:|..:..:..||..|:.|||:.....|
  Rat   919 TKREYTMHDHN----------TLLKEFILHNEGKLKKLQDDAKIAQDAFDDVVKYFGENPKTTPP 973

  Fly  1315 DEFFGIFDSFLAAFAEARHDNESFRRRQEEE--EKRAKQEAELKKRTIERKNKTGLMTSVARNLG 1377
            ..||.:|..|:.|:.:|..:|| .|::||:.  ||..:|||.::::
  Rat   974 SVFFPVFVRFVKAYKQAEEENE-LRKKQEQALMEKLLEQEALMEQQ------------------- 1018

  Fly  1378 LKSGSSNGDPDSPAKGG-----------------DNK-------GEFDDLISALRT-----GDVF 1413
                    ||.||:...                 ||:       |..:|:|:.||.     .|..
  Rat  1019 --------DPKSPSHKSKRQQQELIAELRRRQVKDNRHVYEGKDGAIEDIITDLRNQPYRRADAV 1075

  Fly  1414 GEDMAKFKRSRKARVLNGG 1432
            ...:.:....:..|.:|||
  Rat  1076 RRSVRRRFDDQNLRSVNGG 1094

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:461886	64/269 (24%)
		Drf_FH3	551..737	CDD:461885	41/186 (22%)
		Smc	<765..>875	CDD:440809	26/120 (22%)
		FH2	950..1328	CDD:396655	117/412 (28%)
Fmnl2	XP_038962712.1	Drf_GBD	23..275	CDD:461886	64/269 (24%)
		Drf_FH3	278..475	CDD:461885	65/305 (21%)
		FH2	622..973	CDD:396655	109/366 (30%)