Protein Alignment DAAM and fmnl1

DIOPT Version :9

• Sequence 1: NP_001188522.1
• Gene: DAAM / 31075
• FlyBaseID: FBgn0025641
• Length: 1463
• Species: Drosophila melanogaster
• Sequence 2: NP_001007523.1
• Gene: fmnl1 / 493573
• XenbaseID: XB-GENE-1003193
• Length: 1167
• Species: Xenopus tropicalis
• Alignment Length: 1258
• Identity: 310/1258 - (24%)
• Similarity: 497/1258 - (39%)
• Gaps: 340/1258 - (27%)

  Fly   345 TPTQ-PMPSVDELDTKFAELVEELDLTAPNKEAMLSLPAQKKWQIYCSRKLPLDAADGPDAAAVT 408
            ||:: |.|:..||:.:|..::..::|.....:.:......|||::.|.:          :...|.
 Frog    33 TPSKLPRPNSVELEQRFNVVLNAMNLPPDKIQVLRQYDQDKKWELVCDQ----------ERFQVK 87

  Fly   409 QPPTAEHYIERLKELVVHISLSPEDSPSHELGNRLDGHAAFVDALKTALRTSTHSFVLRFV--EL 471
            .||.|  ||::|:      |.......|.:...|:......:..|:.:|||:...:|..|:  |:
 Frog    88 NPPAA--YIQKLR------SYLDTGGISRKFKRRVQESTQVLRELEISLRTNHIGWVEEFLSPEV 144

  Fly   472 DGLPALLDLL------------------------LQLDIRVAN------SPLHTS---------- 496
            .||.||::.|                        ||..:...|      ||.:|.
 Frog   145 GGLDALVEYLSYAQGSCPIDTECSDNGTPEKSKSLQRSLEDINKSSSSPSPTNTPSRSRNLTARY 209

  Fly   497 ----------------------LIGCIKALMNNSMGRAHVLAHPTAIDTIARSLAADNIRTKIAA 539
                                  .|.|::|:||...|.:.|::|.:.::.|..||:..|.|||...
 Frog   210 NLHSRSTMRNTKHANMKDDVHVCIMCLRAIMNYQSGFSMVMSHSSCVNKITLSLSNKNPRTKALV 274

  Fly   540 LEILGAVCLVPGGHRKVLQAMLHFQVFATERTRFQSIVNDLDRSTYAYR---DNVNLKTALMSFV 601
            ||:|.|||||.|||..:|.|..:|.....|..||:.::.       .:|   .|::...|.|.|:
 Frog   275 LELLAAVCLVRGGHELILSAFNYFMEMCGEGARFEKLME-------YFRTEDSNIDFMVACMQFI 332

  Fly   602 NAVLNYGPGQENLEFRLHLRYEFLMLGIQPVIDKLRTHENETLDRHLDFFEMVRAEDEKEFARRF 666
            |.|::   ..:|:.||:.|:|||.:||:...::.|:..|:|.|.      ..::|..:..|....
 Frog   333 NIVVH---SVKNMNFRVFLQYEFTLLGLDEYLEILKNTESERLQ------VQIQAYLDNIFDVNS 388

  Fly   667 KEEHVDTKSAGSMFELLRRKLSHSPAYPHMLSLLQHMLLLPYTGHCTEHWLLIDRVVQQIVLQVE 731
            ..|..|||:     |:|.          |:..|.:|                :.||.:::
 Frog   389 LLEDTDTKN-----EMLE----------HVEDLQEH----------------LTRVTEKL----- 417

  Fly   732 QRPNSDLIVDPDDPEKQLKLAAESPVHDPDVAPLQIDVAKLVRLLVKEEQLTQARKRADELEREN 796
            |...::.:....:.||||           |....::..|| .:|:|:..|:||           |
 Frog   418 QLTENEYVRRVAELEKQL-----------DQCRREMSSAK-EKLVVQAPQVTQ-----------N 459

  Fly   797 FDVQSRLAKK-----EQELDLRMQEKEDLETGLARMRERLEKESAQHSQAVQRAQTAEMRAEDLQ 856
            ...::.|.|:     |...|...:|..|               :...|.....|.|..:....::
 Frog   460 IVQRTELVKRSVLWVEPAGDTCTEEISD---------------NTFTSDLPSAASTPPLSPSAIR 509

  Fly   857 HRLISEQ-------QERARLERLVT---------EGS---------------------------- 877
            ..|||..       ..|....|..|         |.|
 Frog   510 ITLISPSVTSTDALSSRGNSPRSTTPPALLPSLPESSEIFSIPAPSPVPSSEDSSDTALKASKVN 574

  Fly   878 -IPDDQKVAGLTGCNGAVS----------PPPAPPM--LKAIPPPPP-PMAPSMMP--------- 919
             :|....:...|..:.|.|          |||.||:  :..|||||| ||:..:.|
 Frog   575 PVPSPPSIIDQTQTSNAQSLSRTHDESPPPPPPPPLPSIAEIPPPPPLPMSADVPPPPPLPELSG 639

  Fly   920 -PPPPPCP----GAPPPPPSMAQTMAPAPPKVDLPKKNVPQPTNP-------------------- 959
             |||||.|    |||||||||.....|.||... |....|.|..|
 Frog   640 IPPPPPLPMGEQGAPPPPPSMGAPGVPPPPPPP-PSGFGPAPPPPPGGQPAATLNTGVSIKKPIQ 703

  Fly   960 ----LKSFNWSKLPDAKLQGTVWSELDESKLYNNMELESIDKLFSAYQKNGVSATDGSYEDLRVT 1020
                ::..||..|...::.|||::.|::.|:...:::...::.|.. :..|.|.|..|   ::|.
 Frog   704 TKLRMQVLNWVALKPTQINGTVFTHLNDEKVLQELDMSDFEENFKT-KAQGPSQTTFS---MKVK 764

  Fly  1021 GKAAKQKVLSVIDGRRAQNCTILLSKLKMSDMEISKAILSMDSNEQLQLDMVEQLLKFTPSAEER 1085
            ....:...:|:|:..||:|..|.|.|..:|...|:.||...|. :...:|.:|.|.:|.|:..||
 Frog   765 AAQNQPNKVSLIETNRAKNLAITLRKGGLSPEAITSAIQKYDM-QAFNMDFLELLARFLPTDWER 828

  Fly  1086 ALLDEHSED---IESLARADRFLYEISKIPHYEQRLKSLHYKKRFMLTINDLVPRITSVMEASRE 1147
            ..:..:..|   ::.|...|||:..:..||...:|:.::.:...|....:.|.|::.:::.||..
 Frog   829 QQISRYCRDQKPLDDLTAEDRFMVHLCSIPRLAERVNTMTFMANFPDMASRLKPQLDALIAASMS 893

  Fly  1148 VARSRRLRKLLELVLALGNYMNRGARGNASGFRLASLNRLADTKSSAAKGTTLLHYLVQVIERKF 1212
            :..|.:|:.:||||||.|||||...||.|.||||.||:.|.:|||:..| .|||||:::||..|:
 Frog   894 IKSSDKLKGILELVLAFGNYMNSSKRGAAYGFRLQSLDVLLETKSTDRK-QTLLHYMIRVICEKY 957

  Fly  1213 KDLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEFHRSSGPAQQGDRFLPVMREFH 1277
            ..|.....|:..:.:|:.|||..:..|::.|:.|:..|.:|.        .:|.|..  ::::|.
 Frog   958 SHLSNFYCDLNFMDKAATVSLDSVLADVKSLQAGMEQVQKEF--------TKQDDCL--ILKDFI 1012

  Fly  1278 AQASVRFAELEDKFQDMKTRFDRAVRLFGEDGSVLQPDEFFGIFDSFLAAFAEARHDNESFRRRQ 1342
            ........:|....:..:..:|.||..|||:.....|..||.||..|:.|:.:|..|.|:: ::|
 Frog  1013 KSNMDSLKQLSADAKTAQEAYDAAVGYFGENAKTTPPSTFFPIFVRFIKAYKQAEQDLETW-KKQ 1076

  Fly  1343 EEEEKRAKQE----------------------AELKK-------RTIER-----------KNKTG 1367
            |...:.||.|                      |||.|       |..|:           :|:..
 Frog  1077 ESAVQEAKPETAGKQAPQSPVVKSLRPQVNLMAELNKKLQTKEPRVYEQNWAIEDIITDLRNQPY 1141

  Fly  1368 LMTSVARNLGLK--SGSSNGDPD 1388
            ..|.|.|..|.|  ||.....||
 Frog  1142 RRTDVGRRSGKKQNSGQPLNTPD 1164

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:283920	58/262 (22%)
		Drf_FH3	551..737	CDD:283917	43/188 (23%)
		FliJ	779..>875	CDD:280262	19/116 (16%)
		FH2	950..1328	CDD:280362	112/404 (28%)
fmnl1	NP_001007523.1	Drf_GBD	37..283	CDD:399398	58/263 (22%)
		Drf_FH3	286..>423	CDD:368862	43/188 (23%)
		fibronec_FbpA	390..>601	CDD:411474	46/284 (16%)
		FH2	698..1064	CDD:396655	110/381 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54599
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.950