Protein Alignment DAAM and fmnl3

DIOPT Version :10

• Sequence 1: NP_001188522.1
• Gene: DAAM / 31075
• FlyBaseID: FBgn0025641
• Length: 1463
• Species: Drosophila melanogaster
• Sequence 2: NP_001333083.1
• Gene: fmnl3 / 407694
• ZFINID: ZDB-GENE-030131-1571
• Length: 1047
• Species: Danio rerio
• Alignment Length: 1157
• Identity: 305/1157 - (26%)
• Similarity: 511/1157 - (44%)
• Gaps: 254/1157 - (21%)

  Fly   349 PMPSVDELDTKFAELVEELDLTAPNKEAML-SLPAQKKWQIYCSRKLPLDAADGPDAAAVTQPPT 412
            |||...||:.:||.::..::| .|:|..:| ....:|||.:.|.:          :...|..||
Zfish    23 PMPDPTELEERFAIVLNSMNL-PPDKARLLRQYDNEKKWDLICDQ----------ERFQVKNPP- 75

  Fly   413 AEHYIERLKELVVHISLSPEDSPSHELGNRLDGHAAFVDALKTALRTSTHSFVLRFV--ELDGLP 475
             ..||::|:..     |.|:.: ..:...|:......:..|:.:|||:...:|..|:  |..||.
Zfish    76 -HTYIQKLRGY-----LDPKVT-RKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENRGLD 133

  Fly   476 ALLDLL------LQLDIR----------------------------------------------- 487
            .|::.|      :.||..
Zfish   134 ILVEYLSFAQCAVMLDFEGLENGEDFSLDKAKSWSRSIEDLHQNGCNTLVRSARQSVLRYGSTSN 198

  Fly   488 ---VANSPL-------HTSLIGCIKALMNNSMGRAHVLAHPTAIDTIARSLAADNIRTKIAALEI 542
               :.||.|       |..:: |::|:||...|...|::|..|::.||.||...|.|||...||:
Zfish   199 SKTIKNSRLVSQKDDVHVCIM-CLRAIMNYQYGFNLVMSHAHAVNEIALSLNNKNPRTKALVLEL 262

  Fly   543 LGAVCLVPGGHRKVLQAMLHFQVFATERTRFQSIVNDLDRSTYAYRDNVNLKTALMSFVNAVLNY 607
            |.|||||.|||..:|.|..:|:....|:.||:.:: :..||.   ..|::...|.|.|:|.|::
Zfish   263 LAAVCLVRGGHEIILSAFDNFKEVCKEKHRFEKLM-EYFRSE---DGNIDFMVACMQFINIVVH- 322

  Fly   608 GPGQENLEFRLHLRYEFLMLGIQPVIDKLRTHENETLDRHLDFFEMVRAEDEKEFARRFKEEHVD 672
              ..|::.||:||:|||..||:...::|.:..|::.|.      ..::|..:..|......|..:
Zfish   323 --SVEDMNFRVHLQYEFTKLGLDDFLEKSKHTESDKLS------VQIQAYLDNVFDVGGLLEDAE 379

  Fly   673 TKSAGSMFELLRRKLSHSPAYPHMLSLLQHMLLLPYTGHCTEHWLLIDRVVQQIVLQVEQR---P 734
            ||:.               |...:..|.:|:      .|.||..|.::......|..:|::   .
Zfish   380 TKNV---------------ALEKVEELEEHL------SHVTEKLLDVENETMTKVADLEKQLLHK 423

  Fly   735 NSDLIVDPDDPEKQLKLAAESPVHDPDVAPLQIDVAKLVRLLVKEEQLTQARKRADELERENFDV 799
            :.:|.|..:..|     :|.:.||             .:|.:::|:...        .:|.| ::
Zfish   424 DKELAVIKETYE-----SASTQVH-------------TLRRMIQEKDAA--------FQRHN-NI 461

  Fly   800 QSRLAKKEQELDLRMQEKEDLETGLARMRERLEKESAQHSQAVQRAQTAEMRAEDLQHRLISEQQ 864
            :.:|.:.||:..:|::::.|.:..:..:          .:.||......::|:
Zfish   462 EKQLLELEQQGTIRLRKQPDGDIAIETL----------GAGAVAGTPLTDLRS------------ 504

  Fly   865 ERARLERLVTEGSIPDDQKVAGLTGCNG----AVSPPPAPPMLKAIPPPPPPMAPSM-------- 917
                    :|.|.    ..:.||.|.:.    ||:|||.||.    ||||||.||.:
Zfish   505 --------LTVGM----STIGGLGGTSAVPVEAVAPPPPPPP----PPPPPPPAPPLPSEVESIP 553

  Fly   918 -MPPPPPPCPGAPPPPPSMAQTMAPAPPKVDLPKKNVPQPTNPLKSFNWSKLPDAKLQGTVWSEL 981
             .||||||.||   |.||:..::..:..::..|.|...:    |..|||:.|...::.|||::|:
Zfish   554 IPPPPPPPLPG---PSPSVILSVGLSAIRIKKPIKTKFR----LPVFNWTALKPNQINGTVFNEI 611

  Fly   982 DESKLYNNMELESIDKLFSAYQKNGVSATDGSYEDLRVTGKAAKQKVLS---VIDGRRAQNCTIL 1043
            |:.::...::||..::||.       :...|...||..:.....|||::   ::|..|::|..|.
Zfish   612 DDDRVLEELDLEKFEELFK-------TKAQGPVVDLSCSKSKVSQKVINKVQLLDANRSKNLAIT 669

  Fly  1044 LSKLKMSDMEISKAILSMDSNEQLQLDMVEQLLKFTPSAEERALLDEHSED---IESLARADRFL 1105
            |.|...:..||.|||.:.|. :.|.:|.||.|::|.|:..|..||.::..:   ::.||..|||:
Zfish   670 LRKANKTTEEICKAIQTFDL-KALPVDFVECLMRFLPTEAESKLLRQYERERRPLDQLAEEDRFM 733

  Fly  1106 YEISKIPHYEQRLKSLHYKKRFMLTINDLVPRITSVMEASREVARSRRLRKLLELVLALGNYMNR 1170
            ...|||....||:..:.:...|...:|.|.|::.:::.||..|..|.:|:|:||::||||||||.
Zfish   734 LLFSKIERLTQRMSIITFVGNFNDNVNMLTPQLNAIIAASASVKSSPKLKKILEIILALGNYMNS 798

  Fly  1171 GARGNASGFRLASLNRLADTKSSAAKGTTLLHYLVQVIERKFKDLLKLEDDIPHVREASKVSLGE 1235
            ..||:..||:|.||:.|.||||:..| .|||||:..|::.|:.:|....:::..|.:|:.|||..
Zfish   799 SKRGSVYGFKLQSLDLLLDTKSTDRK-MTLLHYIALVVKEKYPELANFYNELHFVDKAAAVSLEN 862

  Fly  1236 MDKDIQMLRTGLADVAREIEFHRSS---GPAQQGDRFLPVMREFHAQASVRFAELEDKFQDMKT- 1296
            :..|::.|..|:..|.||...|..:   |.||..|                 .:|:...:|.||
Zfish   863 VLLDVKELGKGMDLVRRECSLHDHAVLKGFAQTSD-----------------TQLDKLAKDAKTA 910

  Fly  1297 --RFDRAVRLFGEDGSVLQPDEFFGIFDSFLAAFAEARHDNESFRRRQEE--EEKRAKQEAELKK 1357
              .|:..|..|||......|..||.:|..|:.|:.||..:||. |::|||  .||...|||:...
Zfish   911 EEAFNNVVLYFGESPKTTPPSVFFPVFVRFIRAYKEAVEENEQ-RKKQEEAMREKLLAQEAKQHD 974

  Fly  1358 RTIERKNKTGLMTSVARNLGLKSGSSNGDPDSPAKGGDNKGEFDDLISALRT 1409
            ..::.:.|......:...|..:....:    .|...|.: |..:|:|:.|::
Zfish   975 PKVQAQKKRHQQQELIAELRRRQAKDH----RPVYEGKD-GTIEDIITVLKS 1021

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:461886	62/264 (23%)
		Drf_FH3	551..737	CDD:461885	44/188 (23%)
		Smc	<765..>875	CDD:440809	12/109 (11%)
		FH2	950..1328	CDD:396655	124/389 (32%)
fmnl3	NP_001333083.1	Drf_GBD	23..268	CDD:461886	62/264 (23%)
		Drf_FH3	271..462	CDD:461885	54/251 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	520..561		19/44 (43%)
		FH2	580..945	CDD:396655	126/394 (32%)
		CwlO1	<941..>999	CDD:443091	16/58 (28%)