Protein Alignment DAAM and Frl

DIOPT Version :9

• Sequence 1: NP_001188522.1
• Gene: DAAM / 31075
• FlyBaseID: FBgn0025641
• Length: 1463
• Species: Drosophila melanogaster
• Sequence 2: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Alignment Length: 1346
• Identity: 322/1346 - (23%)
• Similarity: 541/1346 - (40%)
• Gaps: 379/1346 - (28%)

  Fly   277 SNTNGLGLRKWLSGNTSSNETPLQK-----------HYRHQQKKKMPGFRGRRVWCGCFKDDEPP 330
            |:.:...:|.....|.|.:...|||           .|:|   .:.|..|.|
  Fly    25 SHAHHHSMRNGHQHNGSISSGTLQKQDLRYDIGCSSQYQH---VRQPSLRSR------------- 73

  Fly   331 EICVVEGAFTLQTLTPTQPMPSVDELDTKFAELVEELDLTAPNKEAMLSLPAQKKWQIYCSRKLP 395
                           ..||||:.||||.:||:::..:||.....:.:.:...:|||.:.|.:::
  Fly    74 ---------------SQQPMPTTDELDRRFAKVLASMDLPPDKAKLLRNYDDEKKWDMICDQEM- 122

  Fly   396 LDAADGPDAAAVTQPPTAEHYIERLKELVVHISLSPEDSPSHEL--------GNRLDGHAAFVDA 452
            :.|.|         ||:  ||:.:|:..     |.|:.|.||.|        ..::.|.:.....
  Fly   123 VQAKD---------PPS--HYLSKLRTY-----LDPKASRSHRLYLFYFLCQKRKMVGESTSTQV 171

  Fly   453 LK---TALRTSTHSFVLRFVE--LDGLPALLDLL------------------------------- 481
            |:   .:|||:...:|..|::  ..||.||:|.|
  Fly   172 LRDLEISLRTNHIEWVKEFLDDTNQGLDALVDYLSFRLQMMRHEQRLQGVLCASEERLNLTNGGD 236

  Fly   482 ----------------------------------------------------------------- 481
                                                                             
  Fly   237 GGEIVMGNSSSVSPGGGGGLLSHGNSTGHGLANGTLDSRQQHTMSYGFLRPTIADALDSPSLKRR 301

  Fly   482 ----LQLDIRVANSPLHTSLIGCIKALMNNSMGRAHVLAHPTAIDTIARSLAADNIRTKIAALEI 542
                .:|::..|...:|.|:: |::|:|||..|...|:.|..||:.||.||...::|||...||:
  Fly   302 SRHIAKLNMGAATDDIHVSIM-CLRAIMNNKYGFNMVIQHREAINCIALSLIHKSLRTKALVLEL 365

  Fly   543 LGAVCLVPGGHRKVLQAMLHFQVFATERTRFQSIVNDLDRSTYAYRDNVNLKTALMSFVNAVLNY 607
            |.|:|||.|||..:|.:..:|:....|:.|||::: :...:..|:  |::...|.|.|:|.|::
  Fly   366 LAAICLVKGGHEIILGSFDNFKDVCQEKRRFQTLM-EYFMNFEAF--NIDFMVACMQFMNIVVH- 426

  Fly   608 GPGQENLEFRLHLRYEFLMLGIQPVIDKLRTHENETLDRHLDFFEMVRAEDEKEFARRFKEEHVD 672
              ..|::.:|:||:|||..||:...::::|..|:|.|...:.
  Fly   427 --SVEDMNYRVHLQYEFTALGLDKYLERIRLTESEELKVQIS----------------------- 466

  Fly   673 TKSAGSMFELLRRKLSHSPAYPHMLSLLQHMLLLPYTGHCTEHWLLIDRVVQQIVLQVEQRPNSD 737
                               ||                         :|.|.
  Fly   467 -------------------AY-------------------------LDNVF-------------- 473

  Fly   738 LIVDPDDPEKQLKLAAESPVHDPDVAPLQIDVAKLVRLLVKEEQLTQARKRADELERE---NFDV 799
                                   |||.|..|..      .|...|.:.::..|:||||   |.:.
  Fly   474 -----------------------DVAALMEDSE------TKTSALERVQELEDQLEREIDRNSEF 509

  Fly   800 QSRLAKKEQE-LDLRMQEKEDLETGLARMRERLEKESAQHSQAVQRAQTAEMRAEDLQHRLISEQ 863
            ..:.|:.|.| |.|:.:.::     ||.:|::||:|.....:.:|..:....:.:.|.|....|.
  Fly   510 LYKYAELESESLTLKTEREQ-----LAMIRQKLEEELTVMQRMLQHNEQELKKRDTLLHTKNMEL 569

  Fly   864 QERAR-LERLVT--EGSIPDDQKVAGLTGCNGAVS---PPPAPPM------LKAIPPPPPPMAPS 916
            |..:| |.|..:  :||:.:...:||.|  :||.|   |||.|||      ..|.||||||.||.
  Fly   570 QTLSRSLPRSASSGDGSLANGGLMAGST--SGAASLTLPPPPPPMPASPTASSAAPPPPPPPAPP 632

  Fly   917 MMPPPP----------------PPCPGAP-------PPPPSMAQTMAPAPPKVDLPKKNVPQPTN 958
            ..||||                |..|.||       ||||.:|..| |||......|:.||....
  Fly   633 APPPPPGFSPLGSPSGSLASTAPSPPHAPPMLSSFQPPPPPVAGFM-PAPDGAMTIKRKVPTKYK 696

  Fly   959 PLKSFNWSKLPDAKLQGTVWSELDESKLYNNMELESIDKLF----SAYQKNGVSAT--DGSYEDL 1017
             |.:.||..|...:::||:::|||:.|::..::....::.|    ....:||.:.|  |||   |
  Fly   697 -LPTLNWIALKPNQVRGTIFNELDDEKIFKQIDFNEFEERFKIGIGGALRNGSNGTEVDGS---L 757

  Fly  1018 RVTGKAAKQKVLSVIDGRRAQNCTILLSKLKMSDMEISKAILSMDSNEQLQLDMVEQLLKFTPSA 1082
            :.:.:..:...:|:::..|.:|..|...||.|...::..||.|:|. ::|.|:.||.|.|..|:.
  Fly   758 QSSKRFKRPDNVSLLEHTRLRNIAISRRKLGMPIDDVIAAIHSLDL-KKLSLENVELLQKMVPTD 821

  Fly  1083 EERALLDEH---SEDIESLARADRFLYEISKIPHYEQRLKSLHYKKRFMLTINDLVPRITSVMEA 1144
            .|.....|:   .:|.:.|...|:|:.::|::.....:|..::|...|:.:::.:.|::.|:..|
  Fly   822 AEVKSYKEYIIERKDQQLLTEEDKFMLQLSRVERISSKLAIMNYMGNFVDSVHLISPQVQSIAGA 886

  Fly  1145 SREVARSRRLRKLLELVLALGNYMNRGARGNASGFRLASLNRLADTKSSAAKGTTLLHYLVQVIE 1209
            |..:.:||:.:.:||:|||.|||:|...||.|.||:|.||:.|.||||: .|.::||||:|..|.
  Fly   887 STSLKQSRKFKAVLEIVLAFGNYLNSNKRGPAYGFKLQSLDTLIDTKST-DKRSSLLHYIVATIR 950

  Fly  1210 RKFKDLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEFHRSSGPAQQGDRFLPVMR 1274
            .||.:||..|.::....:|:.|:|..:..|:|.|..|:..|.:|.|. |..|....      ::|
  Fly   951 AKFPELLNFESELYGTDKAASVALENVVADVQELEKGMDLVRKEAEL-RVKGAQTH------ILR 1008

  Fly  1275 EFHAQASVRFAELEDKFQDMKTRFDRAVRLFGEDGSVLQPDEFFGIFDSFLAAFAEARHDNESFR 1339
            :|...:..:..:::...:..:..|...|..||:.........||.:...|..||.:  ||.|:.:
  Fly  1009 DFLNNSEDKLKKIKSDLRHAQEAFKECVEYFGDSSRNADAAAFFALIVRFTRAFKQ--HDQENEQ 1071

  Fly  1340 R------------RQEEEEKRAKQEAELKKRTIERKNKTGLMTSVARNLGLKSGSSNGDPDSPAK 1392
            |            ::|.::...:.:...||:.:.......|..:|...|..|:.|..   :....
  Fly  1072 RLRLEKAAALAASKKENDQVLMRNKVNQKKQQLPSNGALSLQEAVINELKSKAHSVR---EKKLL 1133

  Fly  1393 GGDN--KGEFDDLISALRTGDVFGEDMAKFKRSRKARVLNGGGSST 1436
            ..|.  .|..:|::..|::......|..  :||::.|:.|...|.|
  Fly  1134 QQDEVYNGALEDILLGLKSEPYRRADAV--RRSQRRRIDNNRLSRT 1177

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:283920	66/311 (21%)
		Drf_FH3	551..737	CDD:283917	33/185 (18%)
		FliJ	779..>875	CDD:280262	26/102 (25%)
		FH2	950..1328	CDD:280362	110/386 (28%)
Frl	NP_729954.2	Drf_GBD	77..371	CDD:283920	66/311 (21%)
		Drf_FH3	374..567	CDD:283917	60/313 (19%)
		FH2	687..1063	CDD:280362	111/388 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463915
Domainoid	1	1.000	79	1.000	Domainoid score	I2351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	116	1.000	Inparanoid score	I2015
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	1	1.000	-	-		mtm9222
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.920