DRSC/TRiP Functional Genomics Resources

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Protein Alignment DAAM and GRID2IP

DIOPT Version :9

Sequence 1:NP_001188522.1 Gene:DAAM / 31075 FlyBaseID:FBgn0025641 Length:1463 Species:Drosophila melanogaster
Sequence 2:NP_001138590.1 Gene:GRID2IP / 392862 HGNCID:18464 Length:1211 Species:Homo sapiens


Alignment Length:530 Identity:144/530 - (27%)
Similarity:234/530 - (44%) Gaps:89/530 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   849 EMRAEDLQHRLISEQQERARLERLVTEGSIPDDQKVAGLT--GCNGAVSPPPAPPMLKAIPPPPP 911
            ||...|.|...::.       ||......|...::.:.||  ..:..:.|||..|     |||||
Human   709 EMSFHDDQGSFVTN-------ERSSASDCISSSEEGSSLTYSSISDHIPPPPLSP-----PPPPP 761

  Fly   912 -------------------------PMAPSMMPPPPPPCPGAPPPPPSMAQTMAPAPPKVD--LP 949
                                     |:.....|.||||.|..|||.|.       |||.:.  |.
Human   762 LPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPLPPPVPC-------APPMLSRGLG 819

  Fly   950 KKNVPQPTNPLKSFNWSKLPDAKLQGTVWSELDESKLYNNMELESIDKLFSAYQKNGVSATDGSY 1014
            .:........:|...|.::.::  :||:|.:|.|...|        |||....:          |
Human   820 HRRSETSHMSVKRLRWEQVENS--EGTIWGQLGEDSDY--------DKLSDMVK----------Y 864

  Fly  1015 EDLRV---TGKAA----------KQKVLSVIDGRRAQNCTILLSKLKMSDMEISKAILSMDSNEQ 1066
            .||.:   |.|.|          |::|:.::..::|.|.:|||:.||:|..|:.:.::||:. .:
Human   865 LDLELHFGTQKPAKPVPGPEPFRKKEVVEILSHKKAYNTSILLAHLKLSPAELRQVLMSMEP-RR 928

  Fly  1067 LQLDMVEQLLKFTPSAEERALLDEHSEDIESLARADRFLYEISKIPHYEQRLKSLHYKKRFMLTI 1131
            |:...:.|||.|.|.|:|........|....|:..|:|:.::..:|.|:.||:|||::.......
Human   929 LEPAHLAQLLLFAPDADEEQRYQAFREAPGRLSEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKT 993

  Fly  1132 NDLVPRITSVMEASREVARSRRLRKLLELVLALGNYMNRG--ARGNASGFRLASLNRLADTKSSA 1194
            .::...:..:.:||.|:..||:|.|:||.|||:|||:|.|  .....:||::..|..|..||:..
Human   994 EEIRGSLECLRQASLELKNSRKLAKILEFVLAMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVD 1058

  Fly  1195 AKGTTLLHYLVQVIERKFKDLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEFHRS 1259
            .| :|.||.|.:.:.:.|.:||....|:|.|..|:||:...:..|:..|...::::.   :..:|
Human  1059 GK-STFLHILAKSLSQHFPELLGFAQDLPTVPLAAKVNQRALTSDLADLHGTISEIQ---DACQS 1119

  Fly  1260 SGPAQQGDRFLPVMREFHAQASVRFAELEDKFQDMKTRFDRAVRLFGEDGSVLQPDEFFGIFDSF 1324
            ..|:.: |:|..||..|...|......|:...::......:|:..||||......:.|||||..|
Human  1120 ISPSSE-DKFAMVMSSFLETAQPALRALDGLQREAMEELGKALAFFGEDSKATTSEAFFGIFAEF 1183

  Fly  1325 LAAFAEARHD 1334
            ::.|..|..|
Human  1184 MSKFERALSD 1193

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DAAMNP_001188522.1 Drf_GBD 349..548 CDD:283920
Drf_FH3 551..737 CDD:283917
FliJ 779..>875 CDD:280262 6/25 (24%)
FH2 950..1328 CDD:280362 108/392 (28%)
GRID2IPNP_001138590.1 PDZ_signaling 14..74 CDD:238492
HN_L-delphilin-R1_like 133..212 CDD:259820
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 226..269
PDZ_signaling 278..353 CDD:238492
HN_L-delphilin-R2_like 389..468 CDD:259821
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 478..502
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 525..549
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 568..600
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 618..672
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 718..783 14/76 (18%)
FH2 820..1188 CDD:280362 108/393 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1922
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45725
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3069
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.940

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