Protein Alignment DAAM and Inf2

DIOPT Version :10

• Sequence 1: NP_001188522.1
• Gene: DAAM / 31075
• FlyBaseID: FBgn0025641
• Length: 1463
• Species: Drosophila melanogaster
• Sequence 2: XP_038969328.1
• Gene: Inf2 / 362790
• RGDID: 1308350
• Length: 1300
• Species: Rattus norvegicus
• Alignment Length: 1167
• Identity: 285/1167 - (24%)
• Similarity: 498/1167 - (42%)
• Gaps: 254/1167 - (21%)

  Fly   382 AQKKWQIYCSRKLPLDAADGPDAAAVTQPPTAEHYIERLKELVVHISLSPEDSPSHELGNRLDGH 446
            ||:||.....:..|.|:           .||..:......||.:.:...|.
  Rat    32 AQRKWAALKEKLGPQDS-----------DPTEANLESAEPELCIRLLQMPS-------------- 71

  Fly   447 AAFVDALKTALRTSTHSFVLRFVELDGLPALLDLLLQLD----IRVANSPLHTSLIGCIKALMNN 507
            ......|:..|.:|..|::::|:|..||..||:.|.:|.    .|:|::.|..:.|.|::|:||:
  Rat    72 VVNYSGLRKRLESSDGSWMVQFLEQSGLDLLLEALARLSGRGVARIADALLQLTCISCVRAVMNS 136

  Fly   508 SMGRAHVLAHPTAIDTIARSLAADNIRTKIAALEILGAVCLV-PGGHRKVLQAMLHFQVFATERT 571
            ..|..::|::...:..::::|...|:..|....|:|.|:|:. |.||...|.|:.|:::..:::.
  Rat   137 QQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHALTLDALDHYKMVCSQQY 201

  Fly   572 RFQSIVNDLDRSTYAYRDNVNLKTALMSFVNAVLNYGPGQENLEFRLHLRYEFLMLGIQPVIDKL 636
            ||..|:|:|..|     |||.....|:|.:||:: .||  |:|..|..||.||:.|.:..::.:|
  Rat   202 RFSVIMNELSDS-----DNVPYVVTLLSVINALI-LGP--EDLRTRAQLRSEFIGLQLLDILTRL 258

  Fly   637 RTHENETLDRHLDFFEMVRAEDEKEFARRFKEEHVDTKSAGSMFELLRRKLSHSPAYPHMLSLLQ 701
            |..|:..|...|:.||..:||||:|..|  ..:.::..|...:|..|..|:|.|||...:||:||
  Rat   259 RDLEDADLLIQLEAFEEAKAEDEEELQR--VSDGINMNSHQEVFTSLFHKVSCSPASAQLLSVLQ 321

  Fly   702 HML-LLPYTGHCTEHWLLIDRVVQQIVLQVEQRPNSDLIVDPDDPEKQLKLAAESPVHDPDVAPL 765
            .:: |.|........|..::.:|.:.||                      ||:     |.:...|
  Rat   322 GLMHLEPAARSGQLLWEALENLVNRAVL----------------------LAS-----DAEACTL 359

  Fly   766 QIDVAKLVRLLVKEEQLTQARKRADELERENFDVQSRLAKKEQELDLRMQEKEDLETGLARM--R 828
            :..|.:|:.:        :.|.|...|::.:..||:.|.:.:.      ...::..|..|::  |
  Rat   360 EEVVERLLSI--------KGRPRPSPLDKAHKSVQTNLGQNQG------SSSQNTATPTAKVEGR 410

  Fly   829 ERLEKESAQHSQAVQRAQ---TAEMRAEDLQHRLISEQQERARLERLVTEGSIPDDQKVAGLTGC 890
            :.:.....||..::|.:.   ..::.|..|....:|..          |....|....:.| :|.
  Rat   411 QPVVASPCQHVGSIQSSSMDAAPQLAASPLPTPPLSSS----------TPVLPPPPPPLPG-SGA 464

  Fly   891 NGAVSPPPAPPM---------LKAIPPPPPPMAPSM---------MPPPPPPCPGA--------- 928
            ....:|||.||:         :...||||||:.|.:         .||||||.||:
  Rat   465 TSPPAPPPPPPLPPPLPGSGTMSPPPPPPPPLPPPLPGLGAVSPPPPPPPPPLPGSRAVSPPAPP 529

  Fly   929 ----------PPPPPSMAQTMAPAPPKVDLP---------------------------------- 949
                      |||||.....|.|.||...||
  Rat   530 PSLPHSHPLPPPPPPPPLPGMCPVPPPPPLPTAGQVPPPPPLPGFSVPSVVGGVEEIIVAQVDHS 594

  Fly   950 --------KKNVPQPTNPLKSFNWSKLPD--AKLQGTVWSELDESKLYNNME--LESIDKLFS-- 1000
                    .:.|..||..:|..||.|||.  |:.:.::|:.| .|.....:|  ..||::|||
  Rat   595 LGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVARERNSMWATL-SSPCTAEVEPDFSSIEQLFSFP 658

  Fly  1001 -AYQKNGVSATDGSYEDLRVTGKAAKQ-KVLSVIDGRRAQNCTILLSKLKMSDMEISKAILSMDS 1063
             |..|...:|            .|.|: |.::.:|.:::.|..|.|.:.|.|:.|::..|.:.|:
  Rat   659 MAKPKEPSAA------------PARKEPKEVTFLDSKKSLNLNIFLKQFKCSNEEVTGMIQAGDT 711

  Fly  1064 NEQLQLDMVEQLLKFTPSAEERALLDEHSEDIESLARADRFLYEISKIPHYEQRLKSLHYKKRFM 1128
            : :..:::::||||..|...|...|...:||...||.||:|...:..||.|:.|::.:...:...
  Rat   712 S-KFDVEVLKQLLKLLPEKHEIENLRAFTEDRAKLASADQFYILLLDIPCYQLRVECMMLCEGTA 775

  Fly  1129 LTINDLVPRITSVMEASREVARSRRLRKLLELVLALGNYMNRGAR-GNASGFRLASLNRLADTKS 1192
            :.::.:.|:...|:.|...:..|:||....:|:|.:||::|.|:. |:|.||::::|.:|.:|||
  Rat   776 IVLDMVRPKAQLVLTACESLLTSQRLPVFCQLILKIGNFLNYGSHTGDADGFKISTLLKLTETKS 840

  Fly  1193 SAAKGTTLLHYLVQVIERKFKDLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEFH 1257
            ..:: .||||::::.:|:...|||:|..|:....:|:.:.|..:..:.......|.:..|::.
  Rat   841 QQSR-VTLLHHVLEEVEKSHPDLLQLSRDLESPSQAAGIHLEIIHSEASANLKKLLEAERKVS-- 902

  Fly  1258 RSSGPAQQGDRFLPVMREF--HAQASVRFAELEDKFQDM--KTRFDRAVRLFGEDGSVLQPDEFF 1318
             ||.|        .|.:::  ..|||:..:...||..|.  :.:.:.|..|. ||...|..::.|
  Rat   903 -SSIP--------EVQKQYAERLQASIEASRALDKVFDAIEQKKLELADYLC-EDPQKLSLEDTF 957

  Fly  1319 GIFDSFLAAFAEARHDNESFRRRQEEEEKRAKQEAELKKRTIERKNKTGLMTSVARNLGLKSGSS 1383
            ....:|...|..|..:|:..:.:..:.|||.:|.||.:.|  ..:::.|
  Rat   958 STMKTFRDLFTRALKENKDRKEQMAKAEKRKQQLAEEEAR--RPRDEDG---------------- 1004

  Fly  1384 NGDPDSPAKGGDNKGE----FDDLISALRTGDVFGEDMAKFKRSRKARVLNGGGSSTGHTSP 1441
                 .|.:.|..|.|    .|.|::.:|.|         |:..:.||. .|...::|..:|
  Rat  1005 -----KPVRKGPGKQEEVCVIDALLADIRKG---------FQLRKTARG-RGDTEASGRVAP 1051

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:461886	39/169 (23%)
		Drf_FH3	551..737	CDD:461885	59/186 (32%)
		Smc	<765..>875	CDD:440809	18/114 (16%)
		FH2	950..1328	CDD:396655	104/390 (27%)
Inf2	XP_038969328.1	Drf_GBD	24..177	CDD:461886	39/169 (23%)
		Drf_FH3	181..366	CDD:461885	64/221 (29%)
		FH2	603..967	CDD:418645	104/390 (27%)
		WH2_INF2	1013..1042	CDD:409204	9/38 (24%)
		PRK07764	<1030..1217	CDD:236090	7/32 (22%)
		actin-binding sequence	1033..1036	CDD:409204	0/2 (0%)