Protein Alignment DAAM and dia

DIOPT Version :10

• Sequence 1: NP_001188522.1
• Gene: DAAM / 31075
• FlyBaseID: FBgn0025641
• Length: 1463
• Species: Drosophila melanogaster
• Sequence 2: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Alignment Length: 1173
• Identity: 308/1173 - (26%)
• Similarity: 510/1173 - (43%)
• Gaps: 230/1173 - (19%)

  Fly   352 SVDELDTKFAELVEELDLTAPNKEAMLSLPAQKK-----WQIYCSRKL----------PLDAADG 401
            ||.|||.||.|::|::::....:|.:|:...:::     |.:.....|          |:|
  Fly    70 SVAELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFEKPID---- 130

  Fly   402 PDAAAVTQPPTAEHYIERLKELVVHISLSPEDSPSHELGNRLDGHAAF--VDALKTALRTSTHSF 464
                          |:|.|:            :..|..      |..:  |::|:.||.::..|:
  Fly   131 --------------YVEYLQ------------NGEHST------HKVYQCVESLRVALTSNPISW 163

  Fly   465 VLRFVELDGLPALLDLLLQLDIRVANSPLHTSLIGCIKALMNNSMGRAHVLAHP---TAIDTIAR 526
            :..| .:.|:..:..||.:.....:...:....|.|:||:|||:.| .:|:.:|   :.:..:|:
  Fly   164 IKEF-GVAGIGTIEKLLARSKNNASYEKIEFEAIRCLKAIMNNTWG-LNVVLNPDQHSVVLLLAQ 226

  Fly   527 SLAADNIRTKIAALEILGAVCLV--PGGHRKVLQAMLHFQVFATE---RTRFQSIVNDLDRSTYA 586
            ||.....:|...||::|.:.|:|  ..|:.|||:|:.  .:.||.   ..||:.||:.|..|
  Fly   227 SLDPRKPQTMCEALKLLASFCIVYERNGYEKVLRAIT--TIAATSFKASERFRPIVDALFAS--- 286

  Fly   587 YRDNVNLKTAL----MSFVNAVLNYGPGQENLEFRLHLRYEFLMLGIQPVIDK----LRTHENET 643
              |..:.|..|    :.|:|.:.|   ...:|.||||||.|.:.:|:...:|:    :....||.
  Fly   287 --DQQDPKRDLACHSLIFINTLTN---TPTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNEN 346

  Fly   644 LDRHLDFFEMVRAEDEKEFARRFKEEHVDTKSAGSMFELLRRKLSHSPAYPHMLSLLQHMLLL-- 706
            |.:|...|..:|.:|.:||.:||.....:...|...|::|:..::.:.:.|:.||:|||:|.:
  Fly   347 LQQHFKIFNEIREDDFEEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLSILQHLLYIRD 411

  Fly   707 -----PYTGHCTEHWLLIDRVVQQIVLQVEQRPNSDLIVDPDDPEKQLKLAAESPVHDPDVAPLQ 766
                 |      .::.||:..:.|||....       ..||:...:.                ..
  Fly   412 DFYFRP------AYYQLIEECISQIVFHKG-------YCDPNFENRN----------------FN 447

  Fly   767 IDVAKLVRLLVKEEQLTQARKRADELERENFDVQSRLAKKEQELDLRMQEKEDLETGLARMRERL 831
            ||.:.|:..:|::.:..:: ||::|.|           ||.::|:   ..|::.|...|.:.|::
  Fly   448 IDTSLLLDDIVEKAKAKES-KRSEEYE-----------KKIEQLE---SAKQEAEAKAAHLEEKV 497

  Fly   832 EKESAQHSQAVQRAQTAEMRAEDLQHRLISEQQERARLERLVTEGSIPDDQKVAGLTG------- 889
                                      :|:......|.....:.:.:||......|..|
  Fly   498 --------------------------KLMEANGVAAPSPNKLPKVNIPMPPPPPGGGGAPPPPPP 536

  Fly   890 -----CNGAVSPPPAPPML-KAIPPPPPPMAPSMMPPPPPPCP------GAPPPPPSMAQTMAPA 942
                 ..|...|||.|||. :|..|||||..|.|..|||||.|      |.|||||.|...|.|.
  Fly   537 PMPGRAGGGPPPPPPPPMPGRAGGPPPPPPPPGMGGPPPPPMPGMMRPGGGPPPPPMMMGPMVPV 601

  Fly   943 PPKVDLPKKNVPQPTNPLKSFNWSKLPDAKLQG-TVWSELDESKLYNNMELESIDKLFSA--YQK 1004
            .|....|||.. ...||:|..||..:..||:.. ..|.:..|.||..:..|..:...||:  .:|
  Fly   602 LPHGLKPKKKW-DVKNPMKRANWKAIVPAKMSDKAFWVKCQEDKLAQDDFLAELAVKFSSKPVKK 665

  Fly  1005 NGVSATDGSYEDLRVTGKAAKQKVLSVIDGRRAQNCTILL-SKLKMSDMEISKAILSMDSNEQLQ 1068
            ....|.|      :.|....|...|.|:|.:.|||..|:| ..||....|..|..|.....:.|.
  Fly   666 EQKDAVD------KPTTLTKKNVDLRVLDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILS 724

  Fly  1069 LDMVEQLLKFTPSAEERALLDEHSEDIESLARADRFLYEISKIPHYEQRLKSLHYKKRFMLTIND 1133
            .::::||:::.|..|....|.|.....|.|...::|...|.:|.....||.:|::|..:...:.|
  Fly   725 SNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQD 789

  Fly  1134 LVPRITSVMEASREVARSRRLRKLLELVLALGNYMNRGARGNAS-GFRLASLNRLADTKSSAAKG 1197
            :.|.|.:...|..|:..|::..|:|||:|.||||||.|::..|: ||.::.|.:|::||.:..|
  Fly   790 IKPDIVAGTAACEEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNK- 853

  Fly  1198 TTLLHYLVQVIERKFKDLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEFHRSSGP 1262
            .||||||..::|:||.|.|...||:.||.:||:|::..:.|.::.:.:.:.::  |.:...:..|
  Fly   854 QTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVKNL--ETDLQNNKVP 916

  Fly  1263 AQQGDRFLPVMREFHAQASVRFAELEDKFQ-DMKTRFDRAVRLFGEDGSVLQPDEFFGIFDSFLA 1326
            ....|:|..||.:| |:...:..::..|.| .|:..:......:..|.|....:|||....:|..
  Fly   917 QCDDDKFSEVMGKF-AEECRQQVDVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKD 980

  Fly  1327 AFAEARHDNESFRRRQEEEEKRAKQEAELKKRTIERKNKTGLMTSVARNLGLKSGSSNGDPDSPA 1391
            ||..|.:||  .|.|:|.|:||..|||. ::...|::.:.....:|.            |.|:|.
  Fly   981 AFQAAHNDN--VRVREELEKKRRLQEAR-EQSAREQQERQQRKKAVV------------DMDAPQ 1030

  Fly  1392 KGGDNKGEFDDLISALRTGDVFGEDMAKFKRSRKARVLNGGGSSTGHTSPPRHGSLQREESGRER 1456
               ..:|..|.|:.||:||..||:...:.:|.|.|                  |:.:|.:..|.|
  Fly  1031 ---TQEGVMDSLLEALQTGSAFGQRNRQARRQRPA------------------GAERRAQLSRSR 1074

  Fly  1457 ERT 1459
            .||
  Fly  1075 SRT 1077

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:461886	46/215 (21%)
		Drf_FH3	551..737	CDD:461885	56/203 (28%)
		Smc	<765..>875	CDD:440809	17/109 (16%)
		FH2	950..1328	CDD:396655	112/383 (29%)
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	46/215 (21%)
		Drf_FH3	253..453	CDD:461885	60/238 (25%)
		FH2	608..983	CDD:396655	114/385 (30%)