DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DAAM and FMN1

DIOPT Version :9

Sequence 1:NP_001188522.1 Gene:DAAM / 31075 FlyBaseID:FBgn0025641 Length:1463 Species:Drosophila melanogaster
Sequence 2:NP_001264242.1 Gene:FMN1 / 342184 HGNCID:3768 Length:1419 Species:Homo sapiens


Alignment Length:1608 Identity:341/1608 - (21%)
Similarity:569/1608 - (35%) Gaps:469/1608 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 SVLMDKINTTLQSC-------PIVCIN-EPDTHSANTEILQTSPESTLEKPKAAPSGGASTSVTS 64
            :|.:|:.|....:|       .|:.:: |||.|..:....||..:..|                 
Human    37 TVTLDRSNKGFHNCYQVREESDIISLSQEPDEHPGDIFFKQTPTKDIL----------------- 84

  Fly    65 LNGSCIAINGGIGEGATATASAATSTAAGVTKITITSDNGNGNASTSTKAPTTGSSIDGYKNSSL 129
                            |......|.....:|.: ::||:..|         .|..:.:|......
Human    85 ----------------TELYKLTTERERLLTNL-LSSDHILG---------ITMGNQEGKLQELS 123

  Fly   130 VSITSLNSCSDLS---QGSTATLPISSNSCSGNNVSRHPLSNNNSGSDTSSNNFQERFDFEHWKG 191
            ||:...:.|...:   ||.....|::..|..||...|     .:||...|               
Human   124 VSLAPEDDCFQSAGDWQGELPVGPLNKRSTHGNKKPR-----RSSGRRES--------------- 168

  Fly   192 LLSDYNCFHGLYRYWTQCSGRSSSANDNGGGSDQQQSQSNHENGLG---------SEAGSFYTHN 247
                   |..|.:..|:..||....:....|.|  :..|:|...|.         .|.|:...:.
Human   169 -------FGALPQKRTKRKGRGGRESAPLMGKD--KICSSHSLPLSRTRPNLWVLEEKGNLLPNG 224

  Fly   248 ILGYT--------------------FG-YPFGLKEDLDGSGNCNSNCNGSSNTNGLGLRKWLSGN 291
            .|..:                    || :....|:...|......:|: |:...|.|:|:..|| 
Human   225 ALACSLQRRESCPPDIPKTPDTDLGFGSFETAFKDTGLGREVLPPDCS-STEAGGDGIRRPPSG- 287

  Fly   292 TSSNETPLQKHYRHQQKKKMPGFRGRRVWCGCFKDD-EPPEICVVEGAFTLQTLTPTQPMPSVDE 355
            ....:|.|.:  .||..:|.|...         ||: |.|      ...|.:....::.:..|.:
Human   288 LEHQQTGLSE--SHQDPEKHPEAE---------KDEMEKP------AKRTCKQKPVSKVVAKVQD 335

  Fly   356 LDTK---------------------FAELVEELD-LTAPNKEAML--SLPAQKKWQIYCSRKLP- 395
            |.::                     .||.|.:.| ||.|..||..  |....|:.|...|.:.| 
Human   336 LSSQVQRVVKTHSKGKETIAIRPAAHAEFVPKADLLTLPGAEAGAHGSRRQGKERQGDRSSQSPA 400

  Fly   396 -----LDAADGPDAAAVTQPPTAEHYIERLKE--------LVVHISL---SPEDSPSHELGNRLD 444
                 :.:.......||.:.|......|:|.|        ..||.|:   .||.......|..|.
Human   401 GETASISSVSASAEGAVNKVPLKVIESEKLDEAPEGKRLGFPVHTSVPHTRPETRNKRRAGLPLG 465

  Fly   445 GH-AAFVD-------------------------AL-----KTALRTSTHSFVLRFVELDGLPALL 478
            || :.|:|                         ||     .:|.::|||.      :...:|:.|
Human   466 GHKSLFLDLPHKVGPDSSQPRGDKKKPSPPAPAALGKVFNNSASQSSTHK------QTSPVPSPL 524

  Fly   479 DLLL---QLDIRVANSPLHTSLIGCIKALMNNSMGR-AHVLAHPTAIDTIARSLAADNIRTKIAA 539
            ...|   |...|:...|   :|.|..:|.:|:|..| :.|.:...:.||:....:|....||.|:
Human   525 SPRLPSPQQHHRILRLP---ALPGEREAALNDSPCRKSRVFSGCVSADTLEPPSSAKVTETKGAS 586

  Fly   540 LEIL--GAVCLVPG-------GHRKVLQAMLHFQVFATERTRF------QSIVNDL-DRSTYAYR 588
            ...|  |...||||       |..|......|..........|      :....|| :|...|: 
Human   587 PAFLRAGQPRLVPGETLEKSLGPGKTTAEPQHQSPPGISSEGFPWDGFNEQTPKDLPNRDGGAW- 650

  Fly   589 DNVNLKTALMSFVNAVLNY--GPGQENLEFRLHLRYEFLMLGIQPVIDKLRTHENET-LDRHLDF 650
                           ||.|  ||.   ..|.||...|             :::.:|. ||.|.| 
Human   651 ---------------VLGYRAGPA---CPFLLHEERE-------------KSNRSELYLDLHPD- 683

  Fly   651 FEMVRAEDEKEFAR----------RFKEEHVDTKSAGSMFE--LLRRKLSHSPAYPHMLSLLQ-- 701
             ..:..:|::...|          :..||.|..|...:.::  :|..|..|.....::.:..:  
Human   684 -HSLTEQDDRTPGRLQAVWPPPKTKDTEEKVGLKYTEAEYQAAILHLKREHKEEIENLQAQFELR 747

  Fly   702 --HMLLLPYTGHCTEHWLL---IDRVVQQIVLQVEQR------PNSDLIVDPDD--PEKQLKLAA 753
              |:.        .||.::   ::..::.:..::|.|      ...|:.:..||  |.|..:...
Human   748 AFHIR--------GEHAMITARLEETIENLKHELEHRWRGGCEERKDVCISTDDDCPPKTFRNVC 804

  Fly   754 ESPVHDPDVAPLQIDVAKLVRLLVKEEQLTQARKRADEL--ERENFDVQSRLAKKEQELDLR--M 814
                       :|.|....::....|.:.|    |:::|  ::.|....|:|:......|:.  :
Human   805 -----------VQTDRETFLKPCESESKTT----RSNQLVPKKLNISSLSQLSPPNDHKDIHAAL 854

  Fly   815 QEKEDLETGLARMRERLEKESAQHSQAVQRAQTAEMRAEDLQHRLISEQQERARLERLVTEGSIP 879
            |..|    |:|                                   |.||:...    ....|||
Human   855 QPME----GMA-----------------------------------SNQQKALP----PPPASIP 876

  Fly   880 DDQKV-AGLTGCNGAVSP-PPAPPM-----LKAIPPPPPPMAPSMM-----PPPPPPCPGAP--- 929
            ....: :||    |::|| ||.||:     |...||||||:.|...     ||||||.|.:|   
Human   877 PPPPLPSGL----GSLSPAPPMPPVSAGPPLPPPPPPPPPLPPPSSAGPPPPPPPPPLPNSPAPP 937

  Fly   930 --------PPPPSMAQTMAPAPPKV---------DLPKKNVPQPTNPLKSFNWSKLP----DAKL 973
                    ||||.:|   .|.||.:         ..|:|...:|:.|:|...|:::.    ....
Human   938 NPGGPPPAPPPPGLA---PPPPPGLFFGLGSSSSQCPRKPAIEPSCPMKPLYWTRIQISDRSQNA 999

  Fly   974 QGTVWSELDESKLYNNMELESI-DKLFSAYQKNGVSATDGSYEDLRVTGKAAKQKVLSVIDGRRA 1037
            ..|:|..|:|..:.:..|.|.: .|..:..:|..:|.|   ||.     |...:|::.::||:|:
Human  1000 TPTLWDSLEEPDIRDPSEFEYLFSKDTTQQKKKPLSET---YEK-----KNKVKKIIKLLDGKRS 1056

  Fly  1038 QNCTILLSKLKMSDMEISKAILSMDSNEQLQLDMVEQLLKFTPSAEERALLDE-----------H 1091
            |...||:|.|.:...:|.:||.::|       |.|..|.......|.||..||           .
Human  1057 QTVGILISSLHLEMKDIQQAIFNVD-------DSVVDLETLAALYENRAQEDELVKIRKYYETSK 1114

  Fly  1092 SEDIESLARADRFLYEISKIPHYEQRLKSLHYKKRFMLTINDLVPRITSVMEASREVARSRRLRK 1156
            .|:::.|.:.::||:|:::||::.:|.:.:.::..|...|..|..::..:..||:::...:.::.
Human  1115 EEELKLLDKPEQFLHELAQIPNFAERAQCIIFRSVFSEGITSLHRKVEIITRASKDLLHVKSVKD 1179

  Fly  1157 LLELVLALGNYMNRG--ARGNASGFRLASLNRLADTKSSAAKGTTLLHYLVQVIERKFKDLLKLE 1219
            :|.|:||.|||||.|  .||.|.|:.|..|.:|.|.| |...|..|:.|:|:...|.:......|
Human  1180 ILALILAFGNYMNGGNRTRGQADGYSLEILPKLKDVK-SRDNGINLVDYVVKYYLRYYDQEAGTE 1243

  Fly  1220 DDI---PHVRE---ASKVSLGEMDKDIQMLRTGLADVAREIEFHRSSGPAQQGDRFLPVMREFHA 1278
            ..:   |..::   ||:|...::.||::.|:..|....:::.......|.:....|...:.||..
Human  1244 KSVFPLPEPQDFFLASQVKFEDLIKDLRKLKRQLEASEKQMVVVCKESPKEYLQPFKDKLEEFFQ 1308

  Fly  1279 QASVRFAELEDKFQDMKTRFDRAVRLFG---EDG-SVLQPDEFFGIFDSFLAAF-----AEARH- 1333
            :|.......|...::.:..|:..||.||   :.| ..:.|...|.::..|.:.|     .|::: 
Human  1309 KAKKEHKMEESHLENAQKSFETTVRYFGMKPKSGEKEITPSYVFMVWYEFCSDFKTIWKRESKNI 1373

  Fly  1334 DNESFRRRQEE----------EEKRAKQEAELKKRTIERKNKTGLMTS 1371
            ..|..:..||.          |.|:....|.||:|.  |:.:..:.|:
Human  1374 SKERLKMAQESVSKLTSEKKVETKKINPTASLKERL--RQKEASVTTN 1419

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DAAMNP_001188522.1 Drf_GBD 349..548 CDD:283920 60/276 (22%)
Drf_FH3 551..737 CDD:283917 37/227 (16%)
FliJ 779..>875 CDD:280262 15/99 (15%)
FH2 950..1328 CDD:280362 101/405 (25%)
FMN1NP_001264242.1 Microtubule-binding. /evidence=ECO:0000250 1..622 135/684 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 138..194 16/82 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 262..331 19/87 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 343..641 66/306 (22%)
Mediates interaction with alpha-catenin. /evidence=ECO:0000250 456..842 86/451 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 685..711 2/25 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 859..978 43/164 (26%)
FH2 973..1370 CDD:214697 102/412 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1390..1419 7/30 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1922
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.