DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAAM and form3

DIOPT Version :9

Sequence 1:	NP_001188522.1	Gene:	DAAM / 31075	FlyBaseID:	FBgn0025641	Length:	1463	Species:	Drosophila melanogaster
Sequence 2:	NP_001097527.1	Gene:	form3 / 3346238	FlyBaseID:	FBgn0053556	Length:	1717	Species:	Drosophila melanogaster

Alignment Length:	1057	Identity:	259/1057 - (24%)
Similarity:	456/1057 - (43%)	Gaps:	201/1057 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   505 MNNSMGRAHVLAHPTAIDTIARSLAADNIRTKIAALEILGAVCLV-PGGHRKVLQAMLHFQVFAT 568
            |::.:|..:::.:...|..:..:|...|...|....|:|.|:|.. |.|:.:.::.:..::....
  Fly     1 MDSRIGLDYIVENRDYIAKLGAALDTQNATVKKQVFELLSALCAYSPDGYARAIETLEFYKNLKK 65

  Fly   569 ERTRFQSIVNDLDRSTYAYRDNVNLKTALMSFVNAVLNYGPGQENLEFRLHLRYEFLMLGIQPVI 633
            :|.||:.::|:|:.|:.|....::.:.||::|:|.|:   .....|:.|:.:|.||:.|.:.|::
  Fly    66 QRYRFKIVINELELSSAAAHPPLDYQAALLAFINCVI---ISAATLQERIRIRNEFIGLKVLPLL 127

  Fly   634 DKLRTHENETLDRHLDFFEMVRAEDEKEFARRFKEEHVDTKSAGSMFELLRRKLSHS--PAYPHM 696
            :.||               ::.|.:.:..|.......:.::||.|....:....|.|  |: |..
  Fly   128 NNLR---------------LLEAGNVESSASPSPPPSLSSESASSATSPVSGSASTSVTPS-PSP 176

  Fly   697 LSLLQHMLLLPYTGHCTEHWLLIDRVVQQIVLQVEQRPNSDLIVDPDDPEKQLKLAAESPVHDPD 761
            |.|.:.   |.:.|..:.:.....::||.  |:...:...|:||..|...:|.:......:..||
  Fly   177 LHLQRR---LTFCGSLSRYSCAALQLVQN--LKKVAQSVGDIIVQLDVFVEQQECDEAQSLQAPD 236

  Fly   762 VAPLQIDVAKLVRLLVKEEQLTQARKRADELERENF-DVQSRLAKKEQELDLRMQEKEDLETGLA 825
            ...|...:.....:|         |:.||..:...| ::...|        ||:..||.|...:.
  Fly   237 GINLNSHLDVFYAIL---------RQVADTPQEVPFLNILQHL--------LRIDPKEPLSDIIW 284

  Fly   826 RMRERLEKESAQHSQAVQRAQTAEMRAEDLQHRLISEQQERARLERLVTEGSIPDDQKVAGLTGC 890
            ...|||          |.||            .|:...::..||.|      .|..||.| ...|
  Fly   285 DTTERL----------VHRA------------TLLESHEDSVRLLR------TPSSQKFA-CQSC 320

  Fly   891 NGA-------------------VSPPPAPPMLKAIPPPPPPMAPSMMPPPPPPCP----GA---P 929
            .|:                   ..|||.|||..|.||||||......|||||| |    ||   |
  Fly   321 RGSDASSPTRKPSQPVGVSAKTTPPPPPPPMAPAAPPPPPPPINGAAPPPPPP-PMINGGALPPP 384

  Fly   930 PPPPSMAQTMAPAPP----------KVDLPKKNVPQPTNPLKSFNWSKLPDAKLQG--TVWSELD 982
            ||||||.....|..|          .:.||:::.|.|...:|:.||.|:|..|:.|  .:||.:.
  Fly   385 PPPPSMQMASRPRTPDPLAAEAVATAILLPQQDTPAPKAKMKTINWGKIPHNKVLGKQNIWSIVA 449

  Fly   983 ESKLYNNM------ELESIDKLFSA-------YQKNGVSATDGSYEDLRVTGKAAKQKV-LSVID 1033
            .:...:.|      |:|.:..|.:|       ..::|..|..||.....:..|:.|:.. ::::|
  Fly   450 SNHQDSPMQDIDWNEMEGLFCLQTASAQGSPKLGRDGSQAAAGSNGCDTLDRKSKKESTEITLLD 514

  Fly  1034 GRRAQNCTILLSKLKMSDMEISKAILSMDSNEQLQLDMVEQLLKFTPSAEERALLDEHSEDIESL 1098
            |:|:.|..|.|.:.:.|:.:|.: ::...::|::..:.:..|||..|..:|..:|...:.|...|
  Fly   515 GKRSLNVNIFLKQFRTSNDDIIQ-LIRQGAHEEIGAERLRGLLKIMPEVDELDMLKGFNGDKARL 578

  Fly  1099 ARADRFLYEISKIPHYEQRLKSLHYKKRFMLTINDLVPRITSVMEASREVARSRRLRKLLELVLA 1163
            ..|::||.::.::|:|:.|::|:..|:.|...:..|.|.|.|::.|..::..::.|:::|.:|:.
  Fly   579 GNAEKFLLQLLEVPNYKLRIESMLLKEEFAANVAYLEPCINSMLYAGDDLLNNKTLQEVLYMVVV 643

  Fly  1164 LGNYMNRGA-RGNASGFRLASLNRLADTKSSAAKGTTLLHYLVQVIERKFKDLLKLEDDIPHVRE 1227
            .||::|.|. .|||:|.:|:||.:|.|.::: ..|..|:|::....|::..:||:....:.::..
  Fly   644 AGNFLNSGGYAGNAAGVKLSSLQKLTDIRAN-KPGMNLIHFVALQAEKRNPELLQFTGQLSNLES 707

  Fly  1228 ASKVSLGEMDKDIQMLRTGLADVAREIEFHRSSGPAQQGDRFLPVMREFHAQASVRFAELEDKFQ 1292
            |||.:..:::.:|..|...:..:||:||     .||...| ....|.:|...|....:.|:...:
  Fly   708 ASKTTSEQINNEINTLDGRIRRIARQIE-----QPATDVD-IKEQMADFLQAAESELSVLQAGMK 766

  Fly  1293 DMKTRFDRAVRLFGEDGSVLQPDEFFGIFDSFLAAFAEARHDNESFRRRQEEEEK--RAKQEAEL 1355
            .:::...:....|.:|.:..:.:|.|.||.:|...|.:|..:||  ||:|:|::.  |.||..|.
  Fly   767 QVESMRLKMSEFFCDDAATFRLEECFKIFHNFCDKFKQAVKENE--RRQQQEQQATLRRKQREEQ 829

  Fly  1356 KKRTIERKNKTGLMTSVA--------------------RNLGLKSGS-SNG---------DPDSP 1390
            ..|...:..:.|...|.:                    |:||  ||. |||         .||..
  Fly   830 LARRARQIGQAGTPVSDSEHSFLGDAIFDPRASPALSRRHLG--SGEISNGFIRLEQDGASPDIT 892

  Fly  1391 AKGGDNK------GEFDDLISALRTGDVFGEDMAKFKRSRKARVLNGGGSSTGHTSPPR---HGS 1446
            ..|...:      .|.|||:..||:                    :.|....||.|..|   :||
  Fly   893 PNGSLRRRRSRVLAEEDDLMEFLRS--------------------STGPHHDGHNSRERKAAYGS 937

  Fly  1447 LQREESGRERERTVRRQ 1463
            |.|..:.|.|..:..|:
  Fly   938 LDRSWARRARSGSSSRK 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:283920	9/42 (21%)
		Drf_FH3	551..737	CDD:283917	38/187 (20%)
		FliJ	779..>875	CDD:280262	20/96 (21%)
		FH2	950..1328	CDD:280362	98/394 (25%)
form3	NP_001097527.1	Drf_GBD	<1..43	CDD:283920	9/41 (22%)
		Drf_FH3	48..309	CDD:283917	67/329 (20%)
		FH2	415..803	CDD:280362	98/395 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463917
Domainoid	1	1.000	79	1.000	Domainoid score	I2351
eggNOG	1	0.900	-	-		E1_KOG1922
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.780