Protein Alignment DAAM and Diaph2

DIOPT Version :10

• Sequence 1: NP_001188522.1
• Gene: DAAM / 31075
• FlyBaseID: FBgn0025641
• Length: 1463
• Species: Drosophila melanogaster
• Sequence 2: NP_001414307.1
• Gene: Diaph2 / 317189
• RGDID: 1564399
• Length: 1101
• Species: Rattus norvegicus
• Alignment Length: 1316
• Identity: 334/1316 - (25%)
• Similarity: 565/1316 - (42%)
• Gaps: 295/1316 - (22%)

  Fly   211 GRSSSANDNGGGSDQQQSQSNHENGLGSEAGSFYTHNILGYTFGYPFGLKEDLDGSGNCNSNCNG 275
            |.::|....|||.:        |.|:|                      :.:..|:||..:|...
  Rat     5 GAAASGAGGGGGGE--------EPGVG----------------------RSNKRGTGNRAANEEE 39

  Fly   276 SSNTNGLGLR-KWLSGNTSSNETPLQKHYRHQQKKKMPGFRGRRVWCGCFKDDEPPEICVVEGAF 339
            :.|...|.:: |.|:.:.....|..:|....::|..:......:...|     |.|...::....
  Rat    40 TKNKPKLNIQIKTLADDVRDRITSFRKSAIKKEKPLIQHPTDSQAAMG-----EVPSAQILHDER 99

  Fly   340 TLQTLTPTQPMPSVDELDTKFAELVEELDLTAPNKEAMLSLPAQKKWQIYCSRKLPLDAADGPDA 404
            :|        :.|..|:...|.:::|:::|   |:|                :|.||     .|.
  Rat   100 SL--------ILSEKEVLDLFEKMMEDMNL---NEE----------------KKAPL-----RDK 132

  Fly   405 AAVTQPPTAEHYIERLKELVV-------------HISLSPEDSPSHELGNRLDGHAAF--VDALK 454
            ...|:......||....:.:|             ..:||.::. .|||.:.:......  :::|:
  Rat   133 DFTTKREMVVQYISATAKSIVGSKVMGGLKNNKHEFTLSSQEY-VHELRSGISDEKLLNCLESLR 196

  Fly   455 TALRTSTHSFVLRF------VELDGLPALLDLLLQLDIRVANSPLHTSLIGCIKALMNNSMGRAH 513
            .:|.::..|:|..|      |.||.|..|||...|.:|...|   ...:|.|:||.|||..|...
  Rat   197 VSLTSNPVSWVNNFGYEGLGVLLDVLEKLLDKKQQENIDKKN---QYKIIQCLKAFMNNKFGLQR 258

  Fly   514 VLAHPTAIDTIARSL--AADNIRTKIAALEILGAVCLVPGGHRKVLQAMLHFQVFATERT---RF 573
            :|....::..:||::  ...|:.|:|  ::||.|:|:|  |...:|..:|.....|.||.   ||
  Rat   259 ILGDERSLLLLARAIDPKQQNMMTEI--VKILSAICIV--GEENILDKLLGGITAAAERNNRERF 319

  Fly   574 QSIVNDLDRSTYAYRDNVNLKTALMSFVNAVLNYGPGQENLEFRLHLRYEFLMLGIQPVIDKLRT 638
            ..||..|:.:     :.::|:.|.|.|:||::.   ...:|:||:|||.|||..|::.::..|:.
  Rat   320 SPIVEGLENN-----EALHLQVACMQFINALVT---SPYDLDFRIHLRNEFLRCGLKAMLPSLKE 376

  Fly   639 HENETLDRHLDFFEMVRAEDEKEFARRFKEEHVDTKSAGSMFELLRRKLSHSPAYPHMLSLLQHM 703
            .||:.||..|..||..:.:|..|.:.|..:...:......:|.||...|..:.|..::||:|||.
  Rat   377 KENDELDIQLRVFEENKEDDLTELSHRLNDIRAEMDDMNEVFHLLYNMLKDTAAEGYLLSILQHF 441

  Fly   704 LLLPYTGHC-TEHWLLIDRVVQQIVLQVEQRPNSDLIVDPDDPEKQLKLAAESPVHDPDVAPLQI 767
            ||:....:. .:::.:|:..|.||||....       :|||...:|               .:..
  Rat   442 LLIRNDYYIRPQYYKIIEECVSQIVLHCSG-------MDPDFKYRQ---------------RIDF 484

  Fly   768 DVAKLVRLLVKEEQLTQARKRADELERENFDVQSRLAKKEQELDLRMQEKEDLETGLARMRERLE 832
            |...|:...|.:.::.::.::|.|..:          |.::|...|.:.:.:::....:::| ||
  Rat   485 DFTHLIDACVNKAKVEESEQKAMEFSK----------KFDEEFTARQEAQAEIQKRDEKIKE-LE 538

  Fly   833 KESAQHSQAVQRAQTAEMRAEDLQHRLISEQQERARLERLVTEG---SIPDDQKVAGLTGCNGAV 894
            .|                                  :::|..:|   :.|
  Rat   539 SE----------------------------------IQQLQAQGPGSAFP--------------- 554

  Fly   895 SPPPAPPMLKA----IPPPPPPMAPSMMPPPPPPCPG-APPPPPSMAQTMAPAPP---------K 945
            .|||.||:..|    .||||||..|.:.||||||.|| ||||||.....:.|.||         .
  Rat   555 GPPPPPPLPGAGPCPPPPPPPPPLPGVGPPPPPPLPGTAPPPPPLFGAPLLPPPPGGITPSLPGP 619

  Fly   946 VDLP----KKNVPQPTNPLKSFNWSKLPDAKL-QGTVWSELDESKLYNNMELESIDKLFSAY--- 1002
            |:||    :|.:..|...:|..||||:....| :..||.:|.|.| |.|.:|  ..||...:
  Rat   620 VELPYGMKQKKLYNPEVSMKRINWSKIEPRDLSENCVWLKLKEEK-YENPDL--FAKLALTFPSQ 681

  Fly  1003 ---QKNGVSATDGSYEDLRVTGKAAKQKVLSVIDGRRAQNCTILLSKLKMSDMEISKAILSMDSN 1064
               |::|.::     |:.|:..:..|.|.|.::|.:.|||.:|.|...:|...||...||.:  |
  Rat   682 MKGQRHGETS-----EENRIGPQKKKMKELRILDTKTAQNLSIFLGSYRMPYEEIKNIILEV--N 739

  Fly  1065 EQLQLD-MVEQLLKFTPSAEERALLDEHSEDIESLARADRFLYEISKIPHYEQRLKSLHYKKRFM 1128
            |:|..: :::.|:|:.|.......|.:...:.:.|...::|...:|.:.....||.|:.:|..|.
  Rat   740 EELLSEALIQNLVKYLPEQNVLRELAQLKNEYDDLCEPEQFGVVMSTVNMLRPRLTSILFKLTFE 804

  Fly  1129 LTINDLVPRITSVMEASREVARSRRLRKLLELVLALGNYMNRGARGNAS-GFRLASLNRLADTKS 1192
            ..:|::.|.|.:|..|..|:.:|....:||||:|.:|||||.|:|...| ||::..|.::.||||
  Rat   805 EHVNNIKPSIIAVTLACEELKKSESFNRLLELILLVGNYMNSGSRNAQSLGFKINFLCKIKDTKS 869

  Fly  1193 SAAKGTTLLHYLVQVIERKFKDLLKLEDDIPHVREASKVS-------LGEMDKDIQMLRTGLADV 1250
            :..| |||||:|.::.:.:.:|:||..:::.||..|||||       |..|::.|..|.:.:.:.
  Rat   870 ADQK-TTLLHFLAEICDEQHRDILKFPEELEHVESASKVSAQILKSNLVAMEQSILHLESNIKNF 933

  Fly  1251 AREIEFHRSSGPAQQGDRFLPVMREFHAQASVRFAELEDKFQDMKTRFDRAVRLFGEDGSVLQPD 1315
            .:....|         |:|:..|..|...|..::.:|.....:|...::.....|..|.:::..:
  Rat   934 PKAESLH---------DKFVEKMMSFTQNAREQYDKLSTMHSNMLKLYESLGEYFIFDPNIVTIE 989

  Fly  1316 EFFGIFDSFLAAFAEARHDNESFRRRQEEEEKR---AKQEAELKKRTIERKNKTGLMTSVARNLG 1377
            ||||..::|...|.||..:|.. |:..||:.:|   ||::||.:|  :||:.|...:..:
  Rat   990 EFFGDLNTFRTLFLEALKENHK-RKEMEEKSRRAKLAKEKAEQEK--LERQKKKKQLIDI----- 1046

  Fly  1378 LKSGSSNGDPDSPAKGGDNKGEFDDLISALRTGDVFGEDMAKFKRSRKARVLNGGGSSTGHTSPP 1442
                         .|.||..|..|:|:.||::|..|        |.|:.|:             |
  Rat  1047 -------------NKEGDETGVMDNLLEALQSGAAF--------RDRRKRI-------------P 1077

  Fly  1443 RHGSLQREESGRERER 1458
            |:...:|....|.|.|
  Rat  1078 RNPDNRRPTLERSRSR 1093

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:461886	52/221 (24%)
		Drf_FH3	551..737	CDD:461885	56/189 (30%)
		Smc	<765..>875	CDD:440809	13/109 (12%)
		FH2	950..1328	CDD:396655	114/393 (29%)
Diaph2	NP_001414307.1	None