Protein Alignment DAAM and Daam2

DIOPT Version :10

• Sequence 1: NP_001188522.1
• Gene: DAAM / 31075
• FlyBaseID: FBgn0025641
• Length: 1463
• Species: Drosophila melanogaster
• Sequence 2: XP_038940375.1
• Gene: Daam2 / 316201
• RGDID: 1306128
• Length: 1107
• Species: Rattus norvegicus
• Alignment Length: 1216
• Identity: 543/1216 - (44%)
• Similarity: 746/1216 - (61%)
• Gaps: 176/1216 - (14%)

  Fly   308 KKKMPGFRGRRVWCGCFKDDEPPEICVVEGAFTLQTLTPTQPMPSVDELDTKFAELVEELDLTAP 372
            :|:.|  .|....| ||...:.||| .:..:..||.|..:.|:|:.:||:..|||||:|||||..
  Rat     4 RKRSP--HGLGFLC-CFGSSDLPEI-DLRDSHPLQYLEFSSPIPNPEELNVCFAELVDELDLTDK 64

  Fly   373 NKEAMLSLPAQKKWQIYCSRKLPLDAADGPDAAAVTQPPTAEHYIERLKELVVHISL-SPEDSPS 436
            |:||:.:||.:||||||||:|   ...:.|:..|.:.|   |.||:|:..:....:| ..||..:
  Rat    65 NREAVFALPPEKKWQIYCSKK---KEQEDPNKLATSWP---EFYIDRINAMATMQNLYDTEDEET 123

  Fly   437 HELGNRLDGHAAFVDALKTALRTSTHSFVLRFVELDGLPALLDLLLQLDIRVANSPLHTSLIGCI 501
                   |..:..|:.|||||||....||.||:||:||..||:.|..:|.....|.:||||||||
  Rat   124 -------DKRSQVVEDLKTALRTQPMRFVTRFIELEGLSCLLNFLRGMDHATCESRIHTSLIGCI 181

  Fly   502 KALMNNSMGRAHVLAHPTAIDTIARSLAADNIRTKIAALEILGAVCLVPGGHRKVLQAMLHFQVF 566
            |||||||.|||||||.|.||..||:||..:|.:||:|.||||||||||||||:||||||||:||:
  Rat   182 KALMNNSQGRAHVLAQPEAISIIAQSLRTENSKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQVY 246

  Fly   567 ATERTRFQSIVNDLDRSTYAYRDNVNLKTALMSFVNAVLNYGPGQENLEFRLHLRYEFLMLGIQP 631
            |.||||||:::|:||||...|||.||||||:|||:|||||.|.|::|||||||||||||||||||
  Rat   247 AAERTRFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQP 311

  Fly   632 VIDKLRTHENETLDRHLDFFEMVRAEDEKEFARRFKEEHVDTKSAGSMFELLRRKLSHSPAYPHM 696
            ||||||.|||..||:|||||||||.||:.|.||||...|:|||||..||||:.:||.|:.|||.:
  Rat   312 VIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELIHKKLKHTEAYPCL 376

  Fly   697 LSLLQHMLLLPY--TGHCTEHWLLIDRVVQQIVLQVEQRPNSDLIVDPDDPEKQLKLAAESPVHD 759
            ||:|.|.|.:||  .|...:.|.|:||::||||||.|:..                        |
  Rat   377 LSVLHHCLQMPYKRNGGYFQQWQLLDRILQQIVLQDERGV------------------------D 417

  Fly   760 PDVAPLQ-IDVAKLVRLLVKEEQLTQARKRADELERENFDVQSRLAKKEQELDLRMQEKEDLETG 823
            ||:|||: .:|..:|.:|:.|.::.|.|.:|::..:|:.::.|||.:||:|.:.:..|||::...
  Rat   418 PDLAPLENFNVKNIVNMLINENEVKQWRDQAEKFRKEHMELLSRLERKERECETKTLEKEEMMRT 482

  Fly   824 LARMRERLEKESAQHSQAVQRAQTAEMRAEDLQHRLISEQQERARLERLVTEGSIPDDQ-KVAGL 887
            |.:|:::|.:||.:..||  |.|.||:...                   |:....|... .::..
  Rat   483 LNKMKDKLARESQELRQA--RGQVAELTGP-------------------VSSPPPPGGPLTLSSS 526

  Fly   888 TGCNGAVSPPPAPPMLKAIPPPPPPMAPSMMPPPP--PPC--PGAPPPPPSMAQTMAPAPPKVDL 948
            |..|....|||..|:....||||||:.|...|.||  |||  .|:|||...::...||      |
  Rat   527 TTTNDLPPPPPPLPLDNCTPPPPPPLPPGGPPIPPGAPPCFSSGSPPPHEPLSSNEAP------L 585

  Fly   949 PKKNVPQPTNPLKSFNWSKLPDAKLQGTVWSELDESKLYNNMELESIDKLFSAYQKNG------- 1006
            .||.:|||::|||||||.||.:.::.||||:|:|:|:::..::||..:|:|||||::.
  Rat   586 RKKRIPQPSHPLKSFNWVKLNEERVSGTVWNEIDDSQVFRILDLEDFEKMFSAYQRHQGCMQEGA 650

  Fly  1007 ----------------------------------VSATD-----GSYEDLRVTGKAAKQKVLSVI 1032
                                              ||||.     ||.||:.:..:  |.|.||||
  Rat   651 QRERGNVRDGGTASRSLPAAETNDHRTEKASRSMVSATGVKKELGSTEDIYLASR--KVKELSVI 713

  Fly  1033 DGRRAQNCTILLSKLKMSDMEISKAILSMDSNEQLQLDMVEQLLKFTPSAEERALLDEHSEDIES 1097
            ||||||||.|||||||:|:.||.:|||.||..|.|..||:||||||.|...:..||:||..:||.
  Rat   714 DGRRAQNCIILLSKLKLSNEEIRRAILRMDEQEDLAKDMLEQLLKFIPEKSDVDLLEEHKHEIER 778

  Fly  1098 LARADRFLYEISKIPHYEQRLKSLHYKKRFMLTINDLVPRITSVMEASREVARSRRLRKLLELVL 1162
            :|||||||||:|:|.||:|||::|.:||:|...:.:..|::.:::.||:|:..|:||:|:||:||
  Rat   779 MARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLASQELTLSKRLKKMLEVVL 843

  Fly  1163 ALGNYMNRGARGNASGFRLASLNRLADTKSSAAKGTTLLHYLVQVIERKFKDLLKLEDDIPHVRE 1227
            |:||:||:|.||.|.|||:||||::||||||..:..:|||||:.::|:.|.|:|.:..::.|:.:
  Rat   844 AIGNFMNKGQRGGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDILNMPSELLHLSK 908

  Fly  1228 ASKVSLGEMDKDIQMLRTGLADVAREIEFHRSSGPAQQGDRFLPVMREFHAQASVRFAELEDKFQ 1292
            |:||:|.|::|::..||.||..|..|:|:.|... ....|:|:|||.:|...:|..|:|||::..
  Rat   909 AAKVNLAELEKEVGALRRGLRAVEVELEYQRQQA-RDPNDKFVPVMSDFITVSSFSFSELEEQLN 972

  Fly  1293 DMKTRFDRAVRLFGEDGSVLQPDEFFGIFDSFLAAFAEARHDNESFRRRQEEEEKRAKQEAELK- 1356
            :.:.:|.:|:..|||..|.:||||||||||:||.||.|||.|.|:.|||:||:|:||:.|:.||
  Rat   973 EARDKFAKALAHFGEQDSKMQPDEFFGIFDTFLQAFLEARQDLEAMRRRKEEDERRARMESMLKE 1037

  Fly  1357 ---KRTIERKNKTGLMTSVARNLGLKSGSSNGDPDSPAKGG--DNKGEFDDLISALRTGDVFGED 1416
               |...:|:.|.                        ..||  :..||||||:||||:|:||.:|
  Rat  1038 QREKERWQRQRKV------------------------LVGGALEESGEFDDLVSALRSGEVFDKD 1078

  Fly  1417 MAKFKRSRKARVLNGGGSSTGHTSPPRHGSLQREESGRERERTVRR 1462
            :.||||:||                 |.|:...|.:   |||.:.|
  Rat  1079 LNKFKRNRK-----------------RPGNQVAEVT---RERAINR 1104

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:461886	100/199 (50%)
		Drf_FH3	551..737	CDD:461885	125/187 (67%)
		Smc	<765..>875	CDD:440809	30/110 (27%)
		FH2	950..1328	CDD:396655	190/423 (45%)
Daam2	XP_038940375.1	Drf_GBD	41..228	CDD:461886	100/199 (50%)
		Drf_FH3	231..435	CDD:461885	133/227 (59%)
		FH2	587..1008	CDD:396655	190/423 (45%)