Protein Alignment DAAM and Diaph1

DIOPT Version :10

• Sequence 1: NP_001188522.1
• Gene: DAAM / 31075
• FlyBaseID: FBgn0025641
• Length: 1463
• Species: Drosophila melanogaster
• Sequence 2: NP_001100863.3
• Gene: Diaph1 / 307483
• RGDID: 1310707
• Length: 1266
• Species: Rattus norvegicus
• Alignment Length: 1312
• Identity: 344/1312 - (26%)
• Similarity: 555/1312 - (42%)
• Gaps: 320/1312 - (24%)

  Fly   325 KDDEPPEICVVEG------AFTLQTLTPTQPMPSVDELDTKFAELVEELDLTAPNKEAMLSLPAQ 383
            |...|.|:....|      .|||:.|       ..|||: :|..:..:.:...||.
  Rat    19 KGRSPDELPATGGDGGKHKKFTLKRL-------MADELE-RFTSMRIKKEKEKPNS--------- 66

  Fly   384 KKWQIYCSRKLPLDAADGPDAAAV------------------------TQPPTAEHYIERLKELV 424
                  ..|.......|.|.|.::                        .|.|..|..|...:|:|
  Rat    67 ------AHRNSSASYGDDPTAQSLQDISDDQVLVLFEQMLVDMNLNEEKQQPLREKDIVIKREMV 125

  Fly   425 ---VHISLS----PEDSPS-----HELGNRL-DGH-AAFVDALKTALRTSTHSFVLRFVELDGLP 475
               :|.|.:    .|.|.|     .||.:.| |.| .:.:::|:.:|..:..|:|..| ..:||.
  Rat   126 SQYLHTSKAGMNQKESSRSAMMYIQELRSGLRDMHLLSCLESLRVSLNNNPVSWVQTF-GAEGLA 189

  Fly   476 ALLDLLLQL-DIRVANSPLHTS-----LIGCIKALMNNSMGRAHVLAHPTAIDTIARSL--AADN 532
            :|||:|.:| |.:...|..:.|     :|.|:||.|||..|...:|.....|..:.|::  |..|
  Rat   190 SLLDILKRLHDEKEETSGNYDSRNQHEIIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPN 254

  Fly   533 IRTKIAALEILGAVCLVP---GGHRKVLQAMLHFQVFATERT------RFQSIVNDLDRSTYAYR 588
            :  .|.|.::|.|:|::|   ..:.:||:||       |||.      |||.:::.|...|
  Rat   255 M--MIDAAKLLSALCILPQPEDMNERVLEAM-------TERAEMEEVERFQPLLDGLKSGT---- 306

  Fly   589 DNVNLKTALMSFVNAVLNYGPGQENLEFRLHLRYEFLMLGIQPVIDKLRTHENETLDRHLDFFEM 653
             ::.||...:..:||::.  |.:| |:||:|:|.|.:.||:..|:.:||..:|:.:...|:.|:.
  Rat   307 -SIALKVGCLQLINALIT--PAEE-LDFRVHIRSELMRLGLHQVLQELREIDNDDMRVQLNVFDE 367

  Fly   654 VRAEDEKEFARRFKEEHVDTKSAGSMFELLRRKLSHSPAYPHMLSLLQHMLLL--PYTGHCTEHW 716
            ...||..:...|..:..::....|.:|:::...:..|.|.||.||:|||:||:  .|... .:::
  Rat   368 QGDEDFFDLKGRLDDIRMEMDDFGEVFQIILNTVKDSKAEPHFLSILQHLLLVRNDYEAR-PQYY 431

  Fly   717 LLIDRVVQQIVLQVEQRPNSDLIVDPDDPEKQLKLAAESPVHDPDVAPLQIDVAKLVRLLVKEEQ 781
            .||:..|.||||....       .|||...:.                ||||:..||..::.:.:
  Rat   432 KLIEECVSQIVLHKNG-------TDPDFKCRH----------------LQIDIEGLVDQMIDKTK 473

  Fly   782 LTQARKRADELERE-------NFDVQSRLAKKEQELDLRMQ----EKEDLETGLARMRERLEKES 835
            :.::..:|.|||::       ..::|..:.|.|.:.:.::|    ||:.|::         ||:.
  Rat   474 VEKSEAKATELEKKLDSELTARHELQVEMKKMENDFEQKLQDLQGEKDALDS---------EKQQ 529

  Fly   836 AQHSQAVQRAQTAEMRAE--DLQHRLISEQQERARLERLV------TEGSIPDDQKVAGLTGC-- 890
            ....:....|:.:::..|  .|...|...::|.|.|..:.      :..::|....:.|.:|.
  Rat   530 ITTQKQDLEAEVSKLTGEVAKLSKELEDAKKEMASLSAVAVAPSVSSSAAVPQAPPLPGDSGTVI 594

  Fly   891 ----------NGAVSPPPAPPM------------------------------------------- 902
                      .|||.|||.||:
  Rat   595 PPPPPPPPLPGGAVPPPPPPPLPAGTGIPPPPPLPGGACISSSPQLFGSTAIPPPPPLPGATAIP 659

  Fly   903 -------------------------------LKAIPPPPPPMAPSM-------------MPPPPP 923
                                           ...:||||||:..|:             :|||||
  Rat   660 PPPPLPGATAIPPPPPLPGATAIPPPPPLPGATGVPPPPPPLPGSVGVPPPPPLPGGPGLPPPPP 724

  Fly   924 PCPGA---PPPPPSMAQTMAPAPP-----------KVDLPKKNVPQPTNPLKSFNWSKLPDAKL- 973
            |.|||   |||||.|.  :.|.||           ...|..|.|.:|...|:..||||.....|
  Rat   725 PFPGAPGIPPPPPGMG--VPPPPPFGFGIPAAPVLPFGLTPKKVYKPEVQLRRPNWSKFVAEDLS 787

  Fly   974 QGTVWSELDESKLYNNMELESIDKLFSAYQKNGVSATD--GSYEDLRVTGKAAKQKVLSVIDGRR 1036
            |...|:::.|.:..||.....:...|||..|...:..|  |..|...|..|  |.|.|.|:|.:.
  Rat   788 QDCFWTKVKEDRFENNELFAKLTLAFSAQTKTSKAKKDQEGGEEKKSVQKK--KVKELKVLDSKT 850

  Fly  1037 AQNCTILLSKLKMSDMEISKAILSMDSNEQ-LQLDMVEQLLKFTPSAEERALLDEHSEDIESLAR 1100
            |||.:|.|...:|...||...||.:  ||. |...|::.|:|..|..|:..:|.|..|:.:.||.
  Rat   851 AQNLSIFLGSFRMPYQEIKNVILEV--NEAVLTESMIQNLIKQMPEPEQLKMLSELKEEYDDLAE 913

  Fly  1101 ADRFLYEISKIPHYEQRLKSLHYKKRFMLTINDLVPRITSVMEASREVARSRRLRKLLELVLALG 1165
            :::|...:..:|....||.::.:|.:|...:.::.|.|.||..|..|:.:|.....||||.|.:|
  Rat   914 SEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSENFSSLLELTLLVG 978

  Fly  1166 NYMNRGAR-GNASGFRLASLNRLADTKSSAAKGTTLLHYLVQVIERKFKDLLKLEDDIPHVREAS 1229
            ||||.|:| ..|.||.::.|.:|.||||:..| .||||:|.::.|....|:||..|::.||.:||
  Rat   979 NYMNAGSRNAGAFGFNISFLCKLRDTKSADQK-MTLLHFLAELCETDHPDVLKFPDELAHVEKAS 1042

  Fly  1230 KVSLGEMDKDIQMLRTGLADVAREIEFHRSSGPA--QQGDRFLPVMREFHAQASVRFAELEDKFQ 1292
            :||...:.|::..::..:|||.|:::    :.||  .:.|:|:..|..|...|..::.:|.....
  Rat  1043 RVSAENLQKNLDQMKKQIADVERDVQ----NFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHS 1103

  Fly  1293 DMKTRFDRAVRLFGEDGSVLQPDEFFGIFDSFLAAFAEARHDNESFRRRQEEEEKR----AKQEA 1353
            :|:|.:......|..|...|..:|||....:|...|.:|..:|:  :||:.||:.|    ||::|
  Rat  1104 NMETLYKELGDYFVFDPKKLSVEEFFMDLHNFRNMFLQAVKENQ--KRRETEEKMRRAKLAKEKA 1166

  Fly  1354 ELKKRTIERKNKTGLMTSVARNLGLKSGSSNGDPDSPAKGGDNKGEFDDLISALRTGDVFGEDMA 1418
            |  |..:|::.|...:..:           |.:       ||..|..|.|:.||::|       |
  Rat  1167 E--KERLEKQQKREQLIDM-----------NAE-------GDETGVMDSLLEALQSG-------A 1204

  Fly  1419 KFKRSRKARVLN 1430
            .|:|.|..|.:|
  Rat  1205 AFRRKRGPRQVN 1216

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:461886	58/244 (24%)
		Drf_FH3	551..737	CDD:461885	56/193 (29%)
		Smc	<765..>875	CDD:440809	26/128 (20%)
		FH2	950..1328	CDD:396655	124/384 (32%)
Diaph1	NP_001100863.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..42		6/22 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	54..83		6/43 (14%)
		Drf_GBD	88..268	CDD:461886	48/182 (26%)
		Drf_FH3	274..464	CDD:461885	63/228 (28%)
		SMC_prok_B	<429..>564	CDD:274008	34/166 (20%)
		FH2	763..1139	CDD:396655	124/384 (32%)