DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAAM and Fhdc1

DIOPT Version :9

Sequence 1:	NP_001188522.1	Gene:	DAAM / 31075	FlyBaseID:	FBgn0025641	Length:	1463	Species:	Drosophila melanogaster
Sequence 2:	NP_001099907.1	Gene:	Fhdc1 / 295161	RGDID:	1311955	Length:	1148	Species:	Rattus norvegicus

Alignment Length:	544	Identity:	158/544 - (29%)
Similarity:	259/544 - (47%)	Gaps:	67/544 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   884 VAGLTGCNGAVSPPPAPPMLKAIPPPPPP-----MAPSMMPPPPPPCPG---APPPPPSMAQTMA 940
            :.|.|..:.:.:|||.||     ||||.|     ..||..||.|||.||   .|||||.:
  Rat    25 MTGQTSPSASPAPPPPPP-----PPPPCPHSGEGFPPSPPPPLPPPLPGGPPVPPPPPGL----- 79

  Fly   941 PAPPKVDLPKKNVPQPTNPLKSFNWSKLPDAKLQG--TVWSELDESKLYNNMELESIDKLF---- 999
              ||...|...:.......::||.|..:|:.:::|  .:|:...:.:.:..::.::|::||
  Rat    80 --PPASYLNGYSSLGKKKRMRSFFWKTIPEEQVRGKTNIWTLAAKQQHHYQIDKKTIEELFGQQE 142

  Fly  1000 ----SAYQKNGVSATDGSYEDLRVTGKAAKQKVLSVIDGRRAQNCTILLSKLKMSDMEISKAILS 1060
                ::..|.| .|.:.|:.|.|        :.::|:|.:|:.|..|.|.:.|.|...|.:.| .
  Rat   143 DTSKASLPKRG-GALNSSFRDAR--------EEIAVLDAKRSMNIGIFLKQFKKSPQSIVEDI-H 197

  Fly  1061 MDSNEQLQLDMVEQLLKFTPSAEERALLDEHSEDIESLARADRFLYEISKIPHYEQRLKSLHYKK 1125
            ...:|....:.:.::||..|.:||...|...:.|:..|:.||.|||.:.::|:|..|::::..||
  Rat   198 QGRSEHYGSETLREILKLLPESEEVKKLKTFNGDVSKLSLADSFLYCLIQVPNYSLRIEAMVLKK 262

  Fly  1126 RFMLTINDLVPRITSVMEASREVARSRRLRKLLELVLALGNYMNRGA-RGNASGFRLASLNRLAD 1189
            .|:.....|...||::..|.:|:.....|..:|.|||..||.||.|. .|||.||:|:||.:|||
  Rat   263 EFLPFCTSLYKDITTLRAAMKELMLCEELHSILHLVLQAGNIMNAGGYAGNAVGFKLSSLLKLAD 327

  Fly  1190 TKSSAAKGTTLLHYLVQVIERKFKDLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREI 1254
            ||:: ..|..|||::.|..::....||...:.:..|:|.|::||..::.::..|......:...|
  Rat   328 TKAN-KPGMNLLHFVAQEAQKHNTILLNFSEKLQQVQETSRLSLDIIEAELHSLFVRTKSLRENI 391

  Fly  1255 EFHRSSGPAQQGDRFLPVMREFHAQASVRFAELEDKFQDMKTRFDRAVRLFGEDGSVLQPDEFFG 1319
            :  |.....||       |.:|...|..:.||||...::::......:..|.||...::.||.|.
  Rat   392 Q--RDQELRQQ-------MEDFLQFAVEKLAELELWKRELQVEAHTLIDFFCEDKETMKLDECFQ 447

  Fly  1320 IFDSFLAAFAEARHDNESFRRRQEEEEKRAKQEAELKKRTIERKNKTGLMTSVARNLGLKSGSSN 1384
            ||..|...|.:|..||..   |:|:|.|:.::..||:::  .....||.:....|:      ||.
  Rat   448 IFRDFCTRFNKAVKDNHD---REEQERKQLQRLKELEQK--RHSWTTGELGGFGRS------SSE 501

  Fly  1385 GDPDSPAKGGDNKGEFDDLISALR 1408
            .|....||.|.     :||.|.|:
  Rat   502 NDVQMLAKKGT-----EDLPSFLK 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:283920
		Drf_FH3	551..737	CDD:283917
		FliJ	779..>875	CDD:280262
		FH2	950..1328	CDD:280362	106/388 (27%)
Fhdc1	NP_001099907.1	FH2	93..457	CDD:396655	106/383 (28%)
		PTZ00449	<559..760	CDD:185628
		PHA03307	733..>1128	CDD:223039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1922
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820