DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAAM and Grid2ip

DIOPT Version :9

Sequence 1:	NP_001188522.1	Gene:	DAAM / 31075	FlyBaseID:	FBgn0025641	Length:	1463	Species:	Drosophila melanogaster
Sequence 2:	XP_006248928.1	Gene:	Grid2ip / 288484	RGDID:	1310492	Length:	1203	Species:	Rattus norvegicus

Alignment Length:	517	Identity:	143/517 - (27%)
Similarity:	224/517 - (43%)	Gaps:	96/517 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   860 ISEQQERARLERLVTEGSIPDDQKVAGLTGCNGAVSPPPAPPMLKAIPPPPP------------- 911
            :|..:|.:.|    |..||.|.            :.|||..|     |||||
  Rat   723 VSSSEEGSSL----TYSSISDH------------IPPPPLSP-----PPPPPLPFHDPKPSSRTS 766

  Fly   912 ------------PMAPSMMPPPPPPCPGAPPPPPSMAQTMAPAPPKVDLPKKNVPQPTN--PLKS 962
                        |:.....|.||||.|..|||.|.       |||.:.....:....|:  .:|.
  Rat   767 DGPRGPPQSLTKPLTQISHPVPPPPPPPLPPPVPC-------APPMISRGVGHRRSETSHMSVKR 824

  Fly   963 FNWSKLPDAKLQGTVWSELDESKLYNNMELESIDKLFSAYQKNGVSATDGSYEDLRV---TGKA- 1023
            ..|.::.::  :||:|.:|.|...|        |||....:          |.||.:   |.|.
  Rat   825 LRWEQVENS--EGTIWGQLGEDSDY--------DKLSDMVK----------YLDLELHFGTQKPP 869

  Fly  1024 ---------AKQKVLSVIDGRRAQNCTILLSKLKMSDMEISKAILSMDSNEQLQLDMVEQLLKFT 1079
                     .|::|:.::..::|.|.:|||:.||::..|:.:.::||:. .:|:...:.|||.|.
  Rat   870 KPVPGPEPFRKKEVVEILSHKKAYNTSILLAHLKLTPGELRQVLMSMEP-RRLEPAHLAQLLLFA 933

  Fly  1080 PSAEERALLDEHSEDIESLARADRFLYEISKIPHYEQRLKSLHYKKRFMLTINDLVPRITSVMEA 1144
            |.|:|........|....|:..|:|:.::..:|.|:.||:|||::........::...:..:.:|
  Rat   934 PDADEEQRYQAFREAPGRLSEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQA 998

  Fly  1145 SREVARSRRLRKLLELVLALGNYMNRG--ARGNASGFRLASLNRLADTKSSAAKGTTLLHYLVQV 1207
            |.|:..||:|.|:||.|||:|||:|.|  .....:||::..|..|..||:...| :|.||.|.:.
  Rat   999 SLELKNSRKLAKILEFVLAMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGK-STFLHILAKS 1062

  Fly  1208 IERKFKDLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEFHRSSGPAQQGDRFLPV 1272
            :.:.|.:||....|:|.|..|:||:...:..|:    ..|.|...||:....|......|||..|
  Rat  1063 LSQHFPELLGFAQDLPTVPLAAKVNQRALTVDL----ADLHDTVSEIQVACQSMVPSSEDRFAVV 1123

  Fly  1273 MREFHAQASVRFAELEDKFQDMKTRFDRAVRLFGEDGSVLQPDEFFGIFDSFLAAFAEARHD 1334
            |..|...|......|:...::......:|:..||||......:.|||||..|::.|..|..|
  Rat  1124 MTSFLETAQPALRALDGLQREAMEELGKALAFFGEDSKATTSEAFFGIFSEFMSKFERALSD 1185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:283920
		Drf_FH3	551..737	CDD:283917
		FliJ	779..>875	CDD:280262	3/14 (21%)
		FH2	950..1328	CDD:280362	110/394 (28%)
Grid2ip	XP_006248928.1	PDZ_signaling	9..69	CDD:238492
		HN_L-delphilin-R1_like	122..201	CDD:259820
		PDZ_signaling	269..342	CDD:238492
		HN_L-delphilin-R2_like	378..457	CDD:259821
		FH2	812..1180	CDD:280362	110/393 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1922
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45725
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910