DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAAM and DAAM1

DIOPT Version :9

Sequence 1:	NP_001188522.1	Gene:	DAAM / 31075	FlyBaseID:	FBgn0025641	Length:	1463	Species:	Drosophila melanogaster
Sequence 2:	NP_055807.1	Gene:	DAAM1 / 23002	HGNCID:	18142	Length:	1078	Species:	Homo sapiens

Alignment Length:	1174	Identity:	550/1174 - (46%)
Similarity:	771/1174 - (65%)	Gaps:	128/1174 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   312 PGFRGRR----VWCGCFKDDEPPEICV---VEGAFTLQTLTPTQPMPSVDELDTKFAELVEELDL 369
            |..||.|    ::| ||::::.|||..   .:..|.|||:.|..|||.|:|||..|:|||:||||
Human     3 PRKRGGRGISFIFC-CFRNNDHPEITYRLRNDSNFALQTMEPALPMPPVEELDVMFSELVDELDL 66

  Fly   370 TAPNKEAMLSLPAQKKWQIYCSRKLPLDAADGPDAAAVTQPPTAEHYIERLKELVVHISLSPEDS 434
            |..::|||.:|||:||||||||:|     .|..:....|..|  |.||::|..:....||...:.
Human    67 TDKHREAMFALPAEKKWQIYCSKK-----KDQEENKGATSWP--EFYIDQLNSMAARKSLLALEK 124

  Fly   435 PSHELGNRLDGHAAFVDALKTALRTSTHSFVLRFVELDGLPALLDLLLQLDIRVANSPLHTSLIG 499
            ...|..::.      :::|||||||....||.||::||||..:|:.|..:|...:.|.:||||||
Human   125 EEEEERSKT------IESLKTALRTKPMRFVTRFIDLDGLSCILNFLKTMDYETSESRIHTSLIG 183

  Fly   500 CIKALMNNSMGRAHVLAHPTAIDTIARSLAADNIRTKIAALEILGAVCLVPGGHRKVLQAMLHFQ 564
            |||||||||.||||||||..:|:.||:||:.:||:||:|.||||||||||||||:||||||||:|
Human   184 CIKALMNNSQGRAHVLAHSESINVIAQSLSTENIKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQ 248

  Fly   565 VFATERTRFQSIVNDLDRSTYAYRDNVNLKTALMSFVNAVLNYGPGQENLEFRLHLRYEFLMLGI 629
            .:|:||||||:::||||:||..|||.|:||||:|||:||||:.|.|.|:|:||||||||||||||
Human   249 KYASERTRFQTLINDLDKSTGRYRDEVSLKTAIMSFINAVLSQGAGVESLDFRLHLRYEFLMLGI 313

  Fly   630 QPVIDKLRTHENETLDRHLDFFEMVRAEDEKEFARRFKEEHVDTKSAGSMFELLRRKLSHSPAYP 694
            ||||||||.|||.|||||||||||:|.|||.|||:||:..|:|||||..||||.|::|:||.|||
Human   314 QPVIDKLREHENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTKSATQMFELTRKRLTHSEAYP 378

  Fly   695 HMLSLLQHMLLLPY--TGHCTEHWLLIDRVVQQIVLQVEQRPNSDLIVDPDDPEKQLKLAAESPV 757
            |.:|:|.|.|.:||  :|:..::|||:||::||||:|.::.
Human   379 HFMSILHHCLQMPYKRSGNTVQYWLLLDRIIQQIVIQNDKG------------------------ 419

  Fly   758 HDPDVAPLQ-IDVAKLVRLLVKEEQLTQARKRADELERENFDVQSRLAKKEQELDLRMQEKEDLE 821
            .|||..||: .::..:||:||.|.::.|.:::|:::.:|:.::|.:|.|||:|.|.:.||||::.
Human   420 QDPDSTPLENFNIKNVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMM 484

  Fly   822 TGLARMRERLEKESAQHSQAVQRAQTAEMRAE--DLQHRLISEQQERARLERLVTEGSIPDDQKV 884
            ..|.:|:|:||||:.:|.|..|  |.|::.|:  :|..|.:.              .|||....
Human   485 QTLNKMKEKLEKETTEHKQVKQ--QVADLTAQLHELSRRAVC--------------ASIPGGPS- 532

  Fly   885 AGLTGCNGAVSPPPAPPMLKAIPPPPPPMAPSMMPPPPPPC-PGAPPPPPS---MAQTMAP--AP 943
               .|..|...|...|..|.. ||||||:...|:||||||. ||.|||||.   :...|.|  ||
Human   533 ---PGAPGGPFPSSVPGSLLP-PPPPPPLPGGMLPPPPPPLPPGGPPPPPGPPPLGAIMPPPGAP 593

  Fly   944 PKVDLPKKNVPQPTNPLKSFNWSKLPDAKLQGTVWSELDESKLYNNMELESIDKLFSAYQK---- 1004
            ..:.|.||::|||||.||||||||||:.||:||||:|:|::|::..::||.:::.|||||:
Human   594 MGLALKKKSIPQPTNALKSFNWSKLPENKLEGTVWTEIDDTKVFKILDLEDLERTFSAYQRQQDF 658

  Fly  1005 ----NGVSATDGSYEDLRVTGKAAKQKVLSVIDGRRAQNCTILLSKLKMSDMEISKAILSMDSNE 1065
                |.......:.:|  ......|.|.||||||||||||.||||:||:|:.||.:|||:||..|
Human   659 FVNSNSKQKEADAIDD--TLSSKLKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRAILTMDEQE 721

  Fly  1066 QLQLDMVEQLLKFTPSAEERALLDEHSEDIESLARADRFLYEISKIPHYEQRLKSLHYKKRFMLT 1130
            .|..||:||||||.|...:..||:||..:::.:|:|||||:|:|:|.||:|||:||::||:|...
Human   722 DLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKADRFLFEMSRINHYQQRLQSLYFKKKFAER 786

  Fly  1131 INDLVPRITSVMEASREVARSRRLRKLLELVLALGNYMNRGARGNASGFRLASLNRLADTKSSAA 1195
            :.::.|::.::...|.||.||..|::|||:|||.|||||:|.||||.||:::|||::||||||..
Human   787 VAEVKPKVEAIRSGSEEVFRSGALKQLLEVVLAFGNYMNKGQRGNAYGFKISSLNKIADTKSSID 851

  Fly  1196 KGTTLLHYLVQVIERKFKDLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEFHRSS 1260
            |..||||||:.::|.|:..:|.|.:::..:.:|:||::.|:||:|..||:||..|..|:|:.:|.
Human   852 KNITLLHYLITIVENKYPSVLNLNEELRDIPQAAKVNMTELDKEISTLRSGLKAVETELEYQKSQ 916

  Fly  1261 GPAQQGDRFLPVMREFHAQASVRFAELEDKFQDMKTRFDRAVRLFGEDGSVLQPDEFFGIFDSFL 1325
             |.|.||:|:.|:.:|...||..|:::||...:.|..|.:||:.|||:...:||||||||||.||
Human   917 -PPQPGDKFVSVVSQFITVASFSFSDVEDLLAEAKDLFTKAVKHFGEEAGKIQPDEFFGIFDQFL 980

  Fly  1326 AAFAEARHDNESFRRRQEEEEKRAKQEAELKKRTIERKNKTGLMTSVARNLGLKSGSSNGDPDSP 1390
            .|.:||:.:||:.|:::||||:||:.||:||::. ||:.|            ::....|
Human   981 QAVSEAKQENENMRKKKEEEERRARMEAQLKEQR-ERERK------------MRKAKEN------ 1026

  Fly  1391 AKGGDNKGEFDDLISALRTGDVFGEDMAKFKRSRKARVLNGGGSSTGHTSPPRHGSLQREESGRE 1455
               .:..||||||:||||:|:||.:|::|.||:|| |:.|                 |..:|.||
Human  1027 ---SEESGEFDDLVSALRSGEVFDKDLSKLKRNRK-RITN-----------------QMTDSSRE 1070

  Fly  1456 RERT 1459
            |..|
Human  1071 RPIT 1074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:283920	100/198 (51%)
		Drf_FH3	551..737	CDD:283917	124/187 (66%)
		FliJ	779..>875	CDD:280262	30/97 (31%)
		FH2	950..1328	CDD:280362	188/385 (49%)
DAAM1	NP_055807.1	Drf_GBD	45..232	CDD:368864	100/199 (50%)
		Drf_FH3	235..439	CDD:368862	131/227 (58%)
		PRK12704	444..>513	CDD:237177	26/70 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	456..480		9/23 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..585		28/79 (35%)
		FH2	600..984	CDD:366959	189/386 (49%)
		Actin-binding	693..702		7/8 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	987..1034		19/68 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1055..1078		11/38 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159334
Domainoid	1	1.000	385	1.000	Domainoid score	I816
eggNOG	1	0.900	-	-		E1_KOG1922
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H36635
Inparanoid	1	1.050	1008	1.000	Inparanoid score	I285
Isobase	1	0.950	-	0	Normalized mean entropy	S3569
OMA	1	1.010	-	-		QHG54599
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	1	1.000	-	-		oto90231
orthoMCL	1	0.900	-	-		OOG6_102298
Panther	1	1.100	-	-	O	PTHR45725
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	1	1.000	-	-		X1795
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	16	15.790