DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAAM and Fmnl3

DIOPT Version :9

Sequence 1:	NP_001188522.1	Gene:	DAAM / 31075	FlyBaseID:	FBgn0025641	Length:	1463	Species:	Drosophila melanogaster
Sequence 2:	NP_035841.1	Gene:	Fmnl3 / 22379	MGIID:	109569	Length:	1028	Species:	Mus musculus

Alignment Length:	1195	Identity:	320/1195 - (26%)
Similarity:	515/1195 - (43%)	Gaps:	318/1195 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   328 EPPEICVVEGAFTLQTLTPTQ-PMPSVDELDTKFAELVEELDLTAPNKEAML-SLPAQKKWQIYC 390
            |||.:.::        |.|.: |||...||:.:||.::..::| .|:|..:| ....:|||.:.|
Mouse    13 EPPSVPLL--------LPPGKTPMPEPCELEERFALVLSSMNL-PPDKARLLRQYDNEKKWDLIC 68

  Fly   391 SRKLPLDAADGPDAAAVTQPPTAEHYIER------------------------LKELVV-----H 426
            .:          :...|..||  ..||::                        |:||.:     |
Mouse    69 DQ----------ERFQVKNPP--HTYIQKLQSFLDPNVTRKKFRRRVQESTKVLRELEISLRTNH 121

  Fly   427 IS-----LSPE--------------------DSPSHELGNRLDG--------------------- 445
            |.     |:.|                    |....|.|:  ||
Mouse   122 IGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGD--DGAFDKLRSWSRSIEDLQPPNAL 184

  Fly   446 HAAFVDALKTALRTSTHSFVLRFVELDGLPALLD--LLLQLDIRVANSPLHTSLIGCIKALMNNS 508
            .|.|.::|..:.|.|    |||:..|.|..||.:  |:.|.|      .:|..:: |::|:||..
Mouse   185 SAPFTNSLARSARQS----VLRYSTLPGRRALKNSRLVSQKD------DVHVCIL-CLRAIMNYQ 238

  Fly   509 MGRAHVLAHPTAIDTIARSLAADNIRTKIAALEILGAVCLVPGGHRKVLQAMLHFQVFATERTRF 573
            .|...|::||.|::.||.||...|.|||...||:|.|||||.|||..:|.|..:|:....|..||
Mouse   239 YGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKELHRF 303

  Fly   574 QSIVNDLDRSTYAYRD---NVNLKTALMSFVNAVLNYGPGQENLEFRLHLRYEFLMLGIQPVIDK 635
            :.::.       .:|:   |::...|.|.|:|.|::   ..|::.||:||:|||..||::..:.|
Mouse   304 EKLME-------YFRNEDSNIDFMVACMQFINIVVH---SVEDMNFRVHLQYEFTKLGLEEFLQK 358

  Fly   636 LRTHENETLDRHLDFFEMVRAEDEKEFARRFKEEHVDTKSAGSMFELLRRKLSHSPAYPHMLSLL 700
            .|..|:|.|...:                   :.::|     ::|::
Mouse   359 SRHTESEKLQVQI-------------------QAYLD-----NVFDV------------------ 381

  Fly   701 QHMLLLPYTGHCTEHWLLIDRVVQQIVLQ-VEQRPNSDLIVDPDDPEKQLKLAAESPVHDPDVAP 764
                          ..||.|...:.:.|: ||:
Mouse   382 --------------GGLLEDAETKNVALEKVEE-------------------------------- 400

  Fly   765 LQIDVAKLVRLLVKEEQLTQARKRADELERENF----DVQSRLAKKEQELDLRMQEKEDLETGLA 825
                         .||.::...::..:||.||.    :::.:|.::|:||:...:..|:....:.
Mouse   401 -------------LEEHVSHLTEKLLDLENENMMRVAELEKQLLQREKELESIKETYENTSNQVH 452

  Fly   826 RMRERLEKESAQHSQAVQRAQTAEMRAEDLQHRLISEQQERARLERL----VTEGSIPDDQKVAG 886
            .:| ||.||.   .:|.||....|..|..|      |......|.|:    :|||..|.|..:..
Mouse   453 TLR-RLIKEK---EEAFQRRCHLEPSARGL------ESMGGEALARVGPTELTEGIPPSDLDLLA 507

  Fly   887 LTGCNGAVSPPPAPPMLKAIPPPPPPMAPSMMPPPPPP----CPGAPPPP---PSMAQTMAPAPP 944
                       ||||..:.:|.||||..|  :||||||    ||.|||.|   ||:..|:..:..
Mouse   508 -----------PAPPTEETLPLPPPPAPP--LPPPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAI 559

  Fly   945 KVDLPKKNVPQPTNPLKSFNWSKLPDAKLQGTVWSELDESKLYNNMELESIDKLFSAYQKNGVSA 1009
            ::..|.|...:    |..|||:.|...::.|||:||||:.|:..:::|:..::||.       :.
Mouse   560 RIKKPIKTKFR----LPVFNWTALKPNQINGTVFSELDDEKILEDLDLDRFEELFK-------TK 613

  Fly  1010 TDGSYEDLRVTGKAAKQKVLS---VIDGRRAQNCTILLSKLKMSDMEISKAILSMDSNEQLQLDM 1071
            ..|...||..:.....||..|   :::..||:|..|.|.|...|..||.:||.:.|. :.|.:|.
Mouse   614 AQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDL-QTLPVDF 677

  Fly  1072 VEQLLKFTPSAEERALLDEHSED---IESLARADRFLYEISKIPHYEQRLKSLHYKKRFMLTIND 1133
            ||.|::|.|:..|..||.::..:   :|.||..|||:...||:....||:..:.:...|...:..
Mouse   678 VECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQM 742

  Fly  1134 LVPRITSVMEASREVARSRRLRKLLELVLALGNYMNRGARGNASGFRLASLNRLADTKSSAAKGT 1198
            |.|::.:::.||..|..|::|:::||::||||||||...||...||:|.||:.|.||||:..| .
Mouse   743 LTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRK-M 806

  Fly  1199 TLLHYLVQVIERKFKDLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEFHRSSGPA 1263
            ||||::...::.|:.:|.....::..|.:|:.|||..:..|::.|..|:..:.||...|.:|
Mouse   807 TLLHFIALTVKEKYPELANFWQELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNS--- 868

  Fly  1264 QQGDRFLPVMREFHAQASVRFAELEDKFQDMKT---RFDRAVRLFGEDGSVLQPDEFFGIFDSFL 1325
                    |:|.|   .|....:|:...:|.||   .::..||.|||......|..||.:|..|:
Mouse   869 --------VLRNF---LSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFI 922

  Fly  1326 AAFAEARHDNESFRRRQEE--EEKRAKQEA-ELKKRTIERKNK---TGLMTSVARNLGLKSGSSN 1384
            .::.||..:||: |::|||  .||:..||| :|..:|..::||   ..|:..:.|.        .
Mouse   923 RSYKEAEQENEA-RKKQEEVMREKQLAQEAKKLDAKTPSQRNKWQQQELIAELRRR--------Q 978

  Fly  1385 GDPDSPAKGGDNKGEFDDLISALRT 1409
            .....|...|.: |..:|:|:.|::
Mouse   979 AKEHRPVYEGKD-GTIEDIITVLKS 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:283920	70/276 (25%)
		Drf_FH3	551..737	CDD:283917	39/189 (21%)
		FliJ	779..>875	CDD:280262	25/103 (24%)
		FH2	950..1328	CDD:280362	122/386 (32%)
Fmnl3	NP_035841.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		5/22 (23%)
		Drf_GBD	26..278	CDD:283920	70/277 (25%)
		Drf_FH3	281..472	CDD:283917	58/305 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	493..541		23/60 (38%)
		FH2	561..926	CDD:280362	123/391 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54599
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950