Protein Alignment DAAM and Daam1

DIOPT Version :10

• Sequence 1: NP_001188522.1
• Gene: DAAM / 31075
• FlyBaseID: FBgn0025641
• Length: 1463
• Species: Drosophila melanogaster
• Sequence 2: NP_080378.2
• Gene: Daam1 / 208846
• MGIID: 1914596
• Length: 1077
• Species: Mus musculus
• Alignment Length: 1176
• Identity: 557/1176 - (47%)
• Similarity: 775/1176 - (65%)
• Gaps: 133/1176 - (11%)

  Fly   312 PGFRGRR----VWCGCFKDDEPPEICV---VEGAFTLQTLTPTQPMPSVDELDTKFAELVEELDL 369
            |..||.|    ::| ||::::.|||..   .:..|.|||:.|..|||.|:|||..|:|||:||||
Mouse     3 PRKRGGRGISFIFC-CFRNNDHPEITYRLRNDSNFALQTMEPALPMPPVEELDVMFSELVDELDL 66

  Fly   370 TAPNKEAMLSLPAQKKWQIYCSRKLPLDAADGPDAAAVTQPPTAEHYIERLKELVVHISLSPEDS 434
            |..::|||.:|||:||||||||:|     .|..:....|..|  |.||::|..:....||...:.
Mouse    67 TDKHREAMFALPAEKKWQIYCSKK-----KDQEENKGATSWP--EFYIDQLNSMAARKSLLALEK 124

  Fly   435 PSHELGNRLDGHAAFVDALKTALRTSTHSFVLRFVELDGLPALLDLLLQLDIRVANSPLHTSLIG 499
            ...|..::.      :::|||||||....||.||::||||..:|:.|..:|...:.|.:||||||
Mouse   125 EEEEERSKT------IESLKTALRTKPMRFVTRFIDLDGLSCILNFLKTMDYETSESRIHTSLIG 183

  Fly   500 CIKALMNNSMGRAHVLAHPTAIDTIARSLAADNIRTKIAALEILGAVCLVPGGHRKVLQAMLHFQ 564
            |||||||||.||||||||..:|:.||:||:.:||:||:|.||||||||||||||:||||||||:|
Mouse   184 CIKALMNNSQGRAHVLAHSESINVIAQSLSTENIKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQ 248

  Fly   565 VFATERTRFQSIVNDLDRSTYAYRDNVNLKTALMSFVNAVLNYGPGQENLEFRLHLRYEFLMLGI 629
            .:|:||||||:::||||:||..|||.|:||||:|||:||||:.|.|.|:|:||||||||||||||
Mouse   249 KYASERTRFQTLINDLDKSTGRYRDEVSLKTAIMSFINAVLSQGAGVESLDFRLHLRYEFLMLGI 313

  Fly   630 QPVIDKLRTHENETLDRHLDFFEMVRAEDEKEFARRFKEEHVDTKSAGSMFELLRRKLSHSPAYP 694
            ||||||||.|||.|||||||||||:|.|||.|||:||:..|:|||||..||||.||:|:||.|||
Mouse   314 QPVIDKLREHENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTKSATQMFELTRRRLTHSEAYP 378

  Fly   695 HMLSLLQHMLLLPY--TGHCTEHWLLIDRVVQQIVLQVEQRPNSDLIVDPDDPEKQLKLAAESPV 757
            |.:|:|.|.|.:||  :|:..::|||:||::||||:|.::.
Mouse   379 HFMSILHHCLQMPYKRSGNTVQYWLLLDRIIQQIVIQNDKG------------------------ 419

  Fly   758 HDPDVAPLQ-IDVAKLVRLLVKEEQLTQARKRADELERENFDVQSRLAKKEQELDLRMQEKEDLE 821
            .|||..||: .::..:||:||.|.::.|.:::|:::.:|:.::|.:|.|||:|.|.:.||||::.
Mouse   420 QDPDSTPLENFNIKNVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMM 484

  Fly   822 TGLARMRERLEKESAQHSQAVQRAQTAEMRAEDLQHRLISEQQERARLERL-------VTEGSIP 879
            ..|.:|:|:||||:.:|.|..|  |.|::.|:      :.|...||....:       ...|..|
Mouse   485 QTLNKMKEKLEKETTEHKQVKQ--QVADLTAQ------LHELNRRAVCAAVPGGPSPGAPGGPFP 541

  Fly   880 DDQKVAGLTGCNGAVSPPPAPPMLK--AIPPPPPPMAPSMMPPP--PPPCPGAPPPPPSMAQTMA 940
            .    :||    |::.|||.||:|.  |:||||||:.|...|||  |||..|..|||
Mouse   542 S----SGL----GSLLPPPPPPLLSGGALPPPPPPLPPGGPPPPPGPPPLGGVLPPP-------- 590

  Fly   941 PAPPKVDLPKKNVPQPTNPLKSFNWSKLPDAKLQGTVWSELDESKLYNNMELESIDKLFSAYQK- 1004
            .||..:.|.|||:|||||.||||||||||:.||.||||:|:|::|::..::||.:::.|||||:
Mouse   591 GAPVSLTLKKKNIPQPTNALKSFNWSKLPENKLDGTVWTEIDDTKVFKILDLEDLERTFSAYQRQ 655

  Fly  1005 -----NGVSATDGSYEDLRVTGKAAKQKVLSVIDGRRAQNCTILLSKLKMSDMEISKAILSMDSN 1064
                 |.....:....|..::.| .|.|.||||||||||||.||||:||:|:.||.:|||:||..
Mouse   656 QEFFVNNSKQKEADAIDDTLSSK-LKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRAILTMDEQ 719

  Fly  1065 EQLQLDMVEQLLKFTPSAEERALLDEHSEDIESLARADRFLYEISKIPHYEQRLKSLHYKKRFML 1129
            |.|..||:||||||.|...:..||:||..:::.:|:|||||:|:|:|.||:|||:||::||:|..
Mouse   720 EDLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKADRFLFEMSRINHYQQRLQSLYFKKKFAE 784

  Fly  1130 TINDLVPRITSVMEASREVARSRRLRKLLELVLALGNYMNRGARGNASGFRLASLNRLADTKSSA 1194
            .:.::.|::.::...|.||.|||.|::|||:|||.|||||:|.||||.||:::|||::||||||.
Mouse   785 RVAEVKPKVEAIRSGSEEVFRSRALKQLLEVVLAFGNYMNKGQRGNAYGFKISSLNKIADTKSSI 849

  Fly  1195 AKGTTLLHYLVQVIERKFKDLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEFHRS 1259
            .|..||||||:.::|.|:..:|.|.:::..:.:|:||::.|:||:|..||:||..|..|:|:.:|
Mouse   850 DKNITLLHYLITIVENKYPKVLNLSEELRDIPQAAKVNMTELDKEISTLRSGLKAVETELEYQKS 914

  Fly  1260 SGPAQQGDRFLPVMREFHAQASVRFAELEDKFQDMKTRFDRAVRLFGEDGSVLQPDEFFGIFDSF 1324
            . |.|.||:|:.|:.:|...||..|:::||...:.|..|.:||:.|||:...:||||||||||.|
Mouse   915 Q-PPQPGDKFVSVVSQFITLASFSFSDVEDLLAEAKELFTKAVKHFGEEAGKIQPDEFFGIFDQF 978

  Fly  1325 LAAFAEARHDNESFRRRQEEEEKRAKQEAELK-KRTIERKNKTGLMTSVARNLGLKSGSSNGDPD 1388
            |.|.|||:.:||:.|:|:||||:||:.||:|| :|..|||.:....:|
Mouse   979 LQAVAEAKQENENMRKRKEEEERRARLEAQLKEQRERERKVRKAKESS----------------- 1026

  Fly  1389 SPAKGGDNKGEFDDLISALRTGDVFGEDMAKFKRSRKARVLNGGGSSTGHTSPPRHGSLQREESG 1453
                  :..||||||:||||:|:||.:|::|.||:|| |:.|                 |..:|.
Mouse  1027 ------EESGEFDDLVSALRSGEVFDKDLSKLKRNRK-RISN-----------------QVTDSS 1067

  Fly  1454 RERERT 1459
            |||..|
Mouse  1068 RERPIT 1073

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:461886	100/198 (51%)
		Drf_FH3	551..737	CDD:461885	125/187 (67%)
		Smc	<765..>875	CDD:440809	36/117 (31%)
		FH2	950..1328	CDD:396655	191/383 (50%)
Daam1	NP_080378.2	Drf_GBD	45..232	CDD:461886	100/199 (50%)
		Drf_FH3	235..439	CDD:461885	132/227 (58%)
		PRK12704	444..>513	CDD:237177	26/70 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	457..478		8/20 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	526..596		31/85 (36%)
		FH2	600..982	CDD:396655	191/383 (50%)
		Actin-binding. /evidence=ECO:0000250	693..702		7/8 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1007..1033		10/48 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1056..1077		10/36 (28%)