DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAAM and daam-1

DIOPT Version :9

Sequence 1:	NP_001188522.1	Gene:	DAAM / 31075	FlyBaseID:	FBgn0025641	Length:	1463	Species:	Drosophila melanogaster
Sequence 2:	NP_503132.3	Gene:	daam-1 / 186392	WormBaseID:	WBGene00018976	Length:	987	Species:	Caenorhabditis elegans

Alignment Length:	1135	Identity:	344/1135 - (30%)
Similarity:	531/1135 - (46%)	Gaps:	204/1135 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   323 CF-----KDDEPPEICVVEGAFTLQTLTPTQPMPSVDELDTKFAELVEELDLTAPNKEAMLSLPA 382
            ||     |||...:....:..|....|.|.       ::|..|..||:||.|....::.|.:...
Worm    14 CFYRDRDKDDPGKQHVHDDVIFAPAPLDPA-------KIDKDFECLVKELGLNEEKQQEMHNYSM 71

  Fly   383 QKKWQIYCSRKLPLDAADGPDAAAVTQPPTAEHYIERLKELVVHISLSPEDSPSHELGNRLDGHA 447
            :||..:..|:.             ..|...|.|:|..||.|  ..|...:.:...:|
Worm    72 EKKMSLLVSQH-------------CLQTEDASHFIGFLKNL--QQSFVIDSNTIRQL-------- 113

  Fly   448 AFVDALKTALRTSTHSFVLRFVELDGLPALLDLLLQLDIRVANSPLHTSLIGCIKALMNNSMGRA 512
               ..|..:|||..:|::..|:...||..|.:||.|...:..........:..::||:|:..||.
Worm   114 ---QELVISLRTQNYSYLESFISSSGLKLLTELLNQCHQQYTLEQPALFFLYALRALLNSPNGRV 175

  Fly   513 HVL---AHPTAIDTIARSLAADNIRTKIAALEILGAVCLVPG-GHRKVLQAMLHFQVFATERTRF 573
            .||   .|  .:.:|||::...:.:.||.|:|||..:|.:|. ||.:||:|:........|||||
Worm   176 AVLNDEQH--VLVSIARAVDFRDFKCKIVAIEILSGLCFIPDEGHIQVLRAITEVSTLLGERTRF 238

  Fly   574 QSIVNDLDRSTYAYRDNVNLKTALMSFVNAVLNYGPGQENLEFRLHLRYEFLMLGIQPVIDKLRT 638
            |::|:||.|:....||...::||:...:||:|..|..:....:|.|||.|.||||:...:::.|.
Worm   239 QTLVSDLHRTYSTDRDTDRVRTAIFGLINALLRTGAAENCAIYRQHLRSELLMLGMSTTLEQCRE 303

  Fly   639 HENETLDRHLDFFEMVRAEDEKEFARRFKEEH----------VDTKSAGSMFELLRRKLSHSPAY 693
            ..::.|:.|:|.|||:|.|||...|.......          :|.:|...|.|.|..||:||.|.
Worm   304 GASQRLEDHIDLFEMMRKEDEISLAGSCTSSDISMSSETSSPIDFESVVGMAEALHIKLNHSQAL 368

  Fly   694 PHMLSLLQHMLLLPYTGHCTEHWLLIDRVVQQIVLQVEQRPNSDLIVDPDDPEKQLKLAAESPVH 758
            ||..|||||:.::|........|.|.|.::|.:.||......:|:               .||:.
Worm   369 PHFHSLLQHLFMVPSDDQHVPLWRLFDLILQHLTLQTTVNGMTDV---------------NSPLQ 418

  Fly   759 DPDVAPLQIDVAKLVRLLVKEEQLTQARKRADELERENFDVQSRLAKKEQELDLRMQEKEDLETG 823
            :      .:|:::::..|                  :|.....|:||   ||:   :.|||::..
Worm   419 N------HVDMSEILARL------------------QNHCDYERIAK---ELE---KAKEDMDLE 453

  Fly   824 LARMRERLEKESAQHS--QAVQRAQTAEMRAEDLQHRLISEQQERARLERLVTEGSIPDDQKVAG 886
            ..|:.| ||...|..|  :|..|...|...|                       .|.|.|
Worm   454 RTRIME-LENRLADFSDGRAGSRISLASTSA-----------------------SSSPSD----- 489

  Fly   887 LTGCNGAVSPPPAPPMLKAIPPPPPPMAPSMMPPPPPPCPGAPPPPPSMAQTMAPAPPKVDLPKK 951
                     |.|:||:|       ||:.|...||||||..|...||....              |
Worm   490 ---------PCPSPPLL-------PPVCPPAPPPPPPPIGGLTSPPKDAL--------------K 524

  Fly   952 NVPQPTNPLKSFNWSKLPDAKLQGTVWSELDESKLYNNMELESIDKLFSAYQKNGVSATDGSYED 1016
            |||:|...:|:.||.:|...|.:||||..:|:.|:|..::|..:...|:|...:....||..|..
Worm   525 NVPEPPGNMKTLNWQRLTLDKTRGTVWDGIDDEKIYKQLDLTELSGCFAASSSHKDEDTDTLYGT 589

  Fly  1017 LRVTGKAAKQKVLSVIDGRRAQNCTILLSKLKMSDMEISKAILSMDSNEQLQLDMVEQLLKFTPS 1081
            :   .:..:|..::|||.||.|||||:|||||:|..||.:|::|||...:|..||:||:|||.|:
Worm   590 I---NRRPQQANITVIDPRRYQNCTIMLSKLKLSHKEIKQAMMSMDEKCKLPKDMIEQMLKFMPT 651

  Fly  1082 AEERALLDEHSEDIES---LARADRFLYEISKIPHYEQRLKSLHYKKRFMLTINDLVPRITSVME 1143
            .||...::|..:...|   ||.|||::||||.||.:||||:.|:..:.|...:..|||.|..|::
Worm   652 KEELTQINESVQKHGSPTVLALADRYMYEISSIPRFEQRLRCLNIIRSFHDRVEALVPFIQVVLK 716

  Fly  1144 ASREVARSRRLRKLLELVLALGNYMNRGAR-GNASGFRLASLNRLADTKSSAAKGTTLLHYLVQV 1207
            |:....:::|.|::|.::||:|||:|.|.| |||.||.:||:|:|||.|::......|||:||..
Worm   717 ATSSCQQNKRFRQILTIILAIGNYLNFGKRNGNAYGFEMASINKLADVKNALRNDRNLLHFLVNF 781

  Fly  1208 IERKFKDLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEFHRSSGPAQ-------Q 1265
            ||:|:.||.|.:.|...|.||::.|..|...:|:.|...|..|.:|:....|:...:       :
Worm   782 IEKKYPDLTKFKKDFATVTEAARFSQSETAAEIRNLEEALLIVRKELNLLESTTKVELPEHIPPE 846

  Fly  1266 GDRFLPVMREFHAQASVRFAELEDKFQDMKTRFDRAVRLF--GEDGSVLQPDEFFGIFDSFLAAF 1328
            .|||..|.:.|..:|:..:..|:..|::||.:|....:.|  ...|.|..|:|||.:.:.||..|
Worm   847 NDRFALVAKAFIEKATAEYHNLDKMFREMKNKFSDCAKYFCYSPSGGVPVPEEFFSVINKFLNTF 911

  Fly  1329 AEARHDNESFRRRQEEEEKRAKQEAELKKRTIERKNKTGLMTSVARNLGLKSGSSNGDPDSPAKG 1393
            .|.   ::......|||||       :|::||            ||:...|..::.      .|.
Worm   912 NEY---HQQLWAEVEEEEK-------IKRQTI------------ARSFLAKKSTTR------RKE 948

  Fly  1394 GDNKGEFDDLISALRTGDVFGEDMAKFKRS 1423
            ...:.:|:.|||||::||:|.|::::.:.|
Worm   949 NHKERDFEQLISALQSGDIFKEELSRLRTS 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:283920	49/201 (24%)
		Drf_FH3	551..737	CDD:283917	68/196 (35%)
		FliJ	779..>875	CDD:280262	19/97 (20%)
		FH2	950..1328	CDD:280362	148/390 (38%)
daam-1	NP_503132.3	Drf_GBD	39..212	CDD:368864	51/207 (25%)
		Drf_FH3	216..408	CDD:368862	68/191 (36%)
		FH2	524..973	CDD:214697	172/479 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164550
Domainoid	1	1.000	264	1.000	Domainoid score	I1023
eggNOG	1	0.900	-	-		E1_KOG1922
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	443	1.000	Inparanoid score	I924
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54599
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	1	1.000	-	-		oto17907
orthoMCL	1	0.900	-	-		OOG6_102298
Panther	1	1.100	-	-	LDO	PTHR45725
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	1	1.000	-	-		X1795
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.840