Protein Alignment DAAM and DIAPH2

DIOPT Version :10

• Sequence 1: NP_001188522.1
• Gene: DAAM / 31075
• FlyBaseID: FBgn0025641
• Length: 1463
• Species: Drosophila melanogaster
• Sequence 2: NP_006720.1
• Gene: DIAPH2 / 1730
• HGNCID: 2877
• Length: 1101
• Species: Homo sapiens
• Alignment Length: 1255
• Identity: 344/1255 - (27%)
• Similarity: 553/1255 - (44%)
• Gaps: 221/1255 - (17%)

  Fly   263 LDGSGNCNSNCNGSSNTNGLG-LRKWLSGNTSSNETPLQ---------KHYRHQQKKKMPGFRGR 317
            ::..|...|...|.|...|.| ..|..:||.::||...:         |......:.::..||..
Human     1 MEQPGAAASGAGGGSEEPGGGRSNKRSAGNRAANEEETKNKPKLNIQIKTLADDVRDRITSFRKS 65

  Fly   318 RVWCGCFKDDEPPEICVVEGAFTLQTLTPTQPMPSVDELDTKFAELVEELDLTAPNKEAMLSLPA 382
            .|     |.::|.....::....:......||:  .||.....:| .|.|||.....|.| :|..
Human    66 TV-----KKEKPLIQHPIDSQVAMSEFPAAQPL--YDERSLNLSE-KEVLDLFEKMMEDM-NLNE 121

  Fly   383 QKKWQIYCSRKLPLDAADGPDAAAVTQPPTAEHYIER------LKELVVHISLSPEDSPSHELGN 441
            :|        |.||...|     ..|:......||..      ||......:||.::. .|||.:
Human   122 EK--------KAPLRNKD-----FTTKREMVVQYISATAKSGGLKNSKHECTLSSQEY-VHELRS 172

  Fly   442 RLDGHAAF--VDALKTALRTSTHSFVLRF------VELDGLPALLDLLLQLDIRVANSPLHTSLI 498
            .:......  :::|:.:|.::..|:|..|      :.||.|..|||...|.:|...|   ...||
Human   173 GISDEKLLNCLESLRVSLTSNPVSWVNNFGHEGLGLLLDELEKLLDKKQQENIDKKN---QYKLI 234

  Fly   499 GCIKALMNNSMGRAHVLAHPTAIDTIARSL--AADNIRTKIAALEILGAVCLVPGGHRKVLQAML 561
            .|:||.|||..|...:|....::..:||::  ...|:.|:|  ::||.|:|:|  |...:|..:|
Human   235 QCLKAFMNNKFGLQRILGDERSLLLLARAIDPKQPNMMTEI--VKILSAICIV--GEENILDKLL 295

  Fly   562 HFQVFATERT---RFQSIVNDLDRSTYAYRDNVNLKTALMSFVNAVLNYGPGQENLEFRLHLRYE 623
            .....|.||.   ||..||..|:.     ::.:.|:.|.|.|:||::.   ....|:||:|||.|
Human   296 GAITTAAERNNRERFSPIVEGLEN-----QEALQLQVACMQFINALVT---SPYELDFRIHLRNE 352

  Fly   624 FLMLGIQPVIDKLRTHENETLDRHLDFFEMVRAEDEKEFARRFKEEHVDTKSAGSMFELLRRKLS 688
            ||..|::.::..|:..||:.||..|..|:..:.:|..|.:.|..:...:......::.||...|.
Human   353 FLRSGLKTMLPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNMLK 417

  Fly   689 HSPAYPHMLSLLQHMLLLPYTGHC-TEHWLLIDRVVQQIVLQVEQRPNSDLIVDPDDPEKQLKLA 752
            .:.|..:.||:|||.||:....:. .:::.:|:..|.||||....       :|||...:|
Human   418 DTAAENYFLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSG-------MDPDFKYRQ---- 471

  Fly   753 AESPVHDPDVAPLQIDVAKLVRLLVKEEQLTQARKRADELERENFDVQSRLAKKEQELDLRMQEK 817
                       .|.||:..|:...|.:.::.::.::|.|..:          |.::|...|.:.:
Human   472 -----------RLDIDLTHLIDSCVNKAKVEESEQKAAEFSK----------KFDEEFTARQEAQ 515

  Fly   818 EDLETGLARMRERLEKESAQHSQAVQRAQTAEMRAEDLQHRLISEQQERARLERLVTEGSIPDDQ 882
                   |.:::|.||             ..|:.||        .||.|.:.:.|.:...||...
Human   516 -------AELQKRDEK-------------IKELEAE--------IQQLRTQAQVLSSSSGIPGPP 552

  Fly   883 KVAGLTGCNGAVSPPPAPPMLKAIP-PPPPPMAPSMM--PPPPPPCP---GAPPPPPSMAQTMAP 941
            ....|.|. |...||||||:....| |||||..|.||  |||||| |   |.|||||.:..  .|
Human   553 AAPPLPGV-GPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPP-PLLFGGPPPPPPLGG--VP 613

  Fly   942 APPKVDL------PKKNVPQPTNPLKSFNWSKLPDAKL-QGTVWSELDESKLYNNMELESIDKLF 999
            .||.:.|      .:|.:.:|...:|..||||:...:| :...|..:.|.|..|......:...|
Human   614 PPPGISLNLPYGMKQKKMYKPEVSMKRINWSKIEPTELSENCFWLRVKEDKFENPDLFAKLALNF 678

  Fly  1000 SA---YQKNGVSATDGSYEDLRVTGKAAKQ-KVLSVIDGRRAQNCTILLSKLKMSDMEISKAILS 1060
            :.   .|||..:..:      :.||...|: |.|.::|.:.|||.:|.|...:|...:|...||.
Human   679 ATQIKVQKNAEALEE------KKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILE 737

  Fly  1061 MDSNEQLQLDMVEQLLKFTPSAEERALLDEHSE---DIESLARADRFLYEISKIPHYEQRLKSLH 1122
            : :.:.|...:::.|:|..|   |:.:|:|.:|   :.:.|...::|...:|.:...:.||.|:.
Human   738 V-NEDMLSEALIQNLVKHLP---EQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSIL 798

  Fly  1123 YKKRFMLTINDLVPRITSVMEASREVARSRRLRKLLELVLALGNYMNRGARGNAS-GFRLASLNR 1186
            :|..|...||::.|.|.:|..|..|:.:|....:||||||.:|||||.|:|...| ||::..|.:
Human   799 FKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGFKINFLCK 863

  Fly  1187 LADTKSSAAKGTTLLHYLVQVIERKFKDLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVA 1251
            :.||||:..| |||||::..:.|.|::|:||..:::.||..|||||       .|:|::.||.:.
Human   864 IRDTKSADQK-TTLLHFIADICEEKYRDILKFPEELEHVESASKVS-------AQILKSNLASME 920

  Fly  1252 REI-----EFHRSSGPAQQGDRFLPVMREFHAQASVRFAELEDKFQDMKTRFDRAVRLFGEDGSV 1311
            ::|     :..:......|.|:|:..|..|...|..::.:|.....:|...::.....|..|...
Human   921 QQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEKLSTMHNNMMKLYENLGEYFIFDSKT 985

  Fly  1312 LQPDEFFGIFDSFLAAFAEARHDNESFRRRQEEEEKR---AKQEAELKKRTIERKNKTGLMTSVA 1373
            :..:||||..::|...|.||..:|.. ||..||:.:|   ||::||.:|  :||:.|...:..:
Human   986 VSIEEFFGDLNNFRTLFLEAVRENNK-RREMEEKTRRAKLAKEKAEQEK--LERQKKKKQLIDI- 1046

  Fly  1374 RNLGLKSGSSNGDPDSPAKGGDNKGEFDDLISALRTGDVFGEDMAKFKRSRKARVLNGGGSSTGH 1438
                             .|.||..|..|:|:.||::|..|        |.|:.|:
Human  1047 -----------------NKEGDETGVMDNLLEALQSGAAF--------RDRRKRI---------- 1076

  Fly  1439 TSPPRHGSLQREESGRERER 1458
               ||:...:|....|.|.|
Human  1077 ---PRNPDNRRVPLERSRSR 1093

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:461886	58/214 (27%)
		Drf_FH3	551..737	CDD:461885	54/189 (29%)
		Smc	<765..>875	CDD:440809	21/109 (19%)
		FH2	950..1328	CDD:396655	114/391 (29%)
DIAPH2	NP_006720.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		11/42 (26%)
		Drf_GBD	101..284	CDD:461886	55/203 (27%)
		Drf_FH3	292..480	CDD:461885	59/217 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	536..594		24/58 (41%)
		FH2	628..1002	CDD:396655	114/391 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1010..1048		13/58 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1070..1101		9/37 (24%)