DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAAM and DIAPH1

DIOPT Version :9

Sequence 1:	NP_001188522.1	Gene:	DAAM / 31075	FlyBaseID:	FBgn0025641	Length:	1463	Species:	Drosophila melanogaster
Sequence 2:	XP_024310152.1	Gene:	DIAPH1 / 1729	HGNCID:	2876	Length:	1313	Species:	Homo sapiens

Alignment Length:	1361	Identity:	338/1361 - (24%)
Similarity:	550/1361 - (40%)	Gaps:	371/1361 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   325 KDDEPPEICVVEG------AFTLQTLTPTQPMPSVDELDTKFAELVEELDLTAPNKEAMLSLPAQ 383
            |...|.|:....|      .|||:.|       ..|||: :|..:..:.:...||.
Human    19 KGRSPDELPSAGGDGGKSKKFTLKRL-------MADELE-RFTSMRIKKEKEKPNS--------- 66

  Fly   384 KKWQIYCSRKLPLDAADGPDAAAVTQPPTAEHYIERLKELVVHISLSPE-DSPSHE--------- 438
                  ..|.......|.|.|.:: |..:.|..:...:::::.::|:.| ..|..|
Human    67 ------AHRNSSASYGDDPTAQSL-QDVSDEQVLVLFEQMLLDMNLNEEKQQPLREKDIIIKREM 124

  Fly   439 -----------LGNRLDGHAAF------------------VDALKTALRTSTHSFVLRFVELDGL 474
                       :..:....:|.                  :::|:.:|..:..|:|..| ..:||
Human   125 VSQYLYTSKAGMSQKESSKSAMMYIQELRSGLRDMPLLSCLESLRVSLNNNPVSWVQTF-GAEGL 188

  Fly   475 PALLDLLLQL-DIRVANSPLHTS-----LIGCIKALMNNSMGRAHVLAHPTAIDTIARSL--AAD 531
            .:|||:|.:| |.:...:..:.|     :|.|:||.|||..|...:|.....|..:.|::  |..
Human   189 ASLLDILKRLHDEKEETAGSYDSRNKHEIIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVP 253

  Fly   532 NIRTKIAALEILGAVCLVP---GGHRKVLQAMLHFQVFATERT------RFQSIVNDLDRSTYAY 587
            |:  .|.|.::|.|:|::|   ..:.:||:||       |||.      |||.:::.|...|
Human   254 NM--MIDAAKLLSALCILPQPEDMNERVLEAM-------TERAEMDEVERFQPLLDGLKSGT--- 306

  Fly   588 RDNVNLKTALMSFVNAVLNYGPGQENLEFRLHLRYEFLMLGIQPVIDKLRTHENETLDRHLDFFE 652
              .:.||...:..:||::.  |.:| |:||:|:|.|.:.||:..|:..||..|||.:...|:.|:
Human   307 --TIALKVGCLQLINALIT--PAEE-LDFRVHIRSELMRLGLHQVLQDLREIENEDMRVQLNVFD 366

  Fly   653 MVRAEDEKEFARRFKEEHVDTKSAGSMFELLRRKLSHSPAYPHMLSLLQHMLLL--PYTGHCTEH 715
            ....||..:...|..:..::......:|::|...:..|.|.||.||:|||:||:  .|... .::
Human   367 EQGEEDSYDLKGRLDDIRMEMDDFNEVFQILLNTVKDSKAEPHFLSILQHLLLVRNDYEAR-PQY 430

  Fly   716 WLLIDRVVQQIVLQVEQRPNSDLIVDPDDPEKQLKLAAESPVHDPD--VAPLQIDVAKLVRLLVK 778
            :.||:..:.||||.                    |..|     |||  ...|||::..|:..::.
Human   431 YKLIEECISQIVLH--------------------KNGA-----DPDFKCRHLQIEIEGLIDQMID 470

  Fly   779 EEQLTQARKRADELERE-------NFDVQSRLAKKEQELDLRMQ----EKEDLET---GLARMRE 829
            :.::.::..:|.|||::       ..::|..:.|.|.:.:.::|    ||:.|.:   .:|..::
Human   471 KTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQKLQDLQGEKDALHSEKQQIATEKQ 535

  Fly   830 RLEKESAQHSQAVQRAQTAEMRAEDLQHRLISEQQERARLE--RLVTEGSIPDDQKV---AGLTG 889
            .||.|.:|.:..|.:          |...|...::|.|.|.  .:....|:|....|   ..|.|
Human   536 DLEAEVSQLTGEVAK----------LTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPG 590

  Fly   890 CNGAVSPPP-----------------------------APPMLKA-------------------- 905
            .:|.:.|||                             :||.|..
Human   591 DSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPP 655

  Fly   906 -------------------------------IPPPPPPMAPSM--------------MPPPPPPC 925
                                           |||||||:..|.              |||||||.
Human   656 PLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPL 720

  Fly   926 PGA---------------PPPPPSMAQTMAPAPP-----------KVDLPKKNVPQPTNPLKSFN 964
            ||.               |||||.|.  |.|.||           ...|..|.:.:|...|:..|
Human   721 PGGPGIPPPPPFPGGPGIPPPPPGMG--MPPPPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPN 783

  Fly   965 WSKLPDAKL-QGTVWSELDESKLYNNMELESIDKLFSAYQKNGVSATD--GSYEDLRVTGKAAKQ 1026
            ||||....| |...|:::.|.:..||.....:...|||..|...:..|  |..|...|..|  |.
Human   784 WSKLVAEDLSQDCFWTKVKEDRFENNELFAKLTLTFSAQTKTSKAKKDQEGGEEKKSVQKK--KV 846

  Fly  1027 KVLSVIDGRRAQNCTILLSKLKMSDMEISKAILSMDSNEQ-LQLDMVEQLLKFTPSAEERALLDE 1090
            |.|.|:|.:.|||.:|.|...:|...||...||.:  ||. |...|::.|:|..|..|:..:|.|
Human   847 KELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEV--NEAVLTESMIQNLIKQMPEPEQLKMLSE 909

  Fly  1091 HSEDIESLARADRFLYEISKIPHYEQRLKSLHYKKRFMLTINDLVPRITSVMEASREVARSRRLR 1155
            ..::.:.||.:::|...:..:|....||.::.:|.:|...:.::.|.|.||..|..|:.:|....
Human   910 LKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSESFS 974

  Fly  1156 KLLELVLALGNYMNRGAR-GNASGFRLASLNRLADTKSSAAKGTTLLHYLVQVIERKFKDLLKLE 1219
            .|||:.|.:|||||.|:| ..|.||.::.|.:|.||||:..| .||||:|.::.|..:.|:||..
Human   975 NLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQK-MTLLHFLAELCENDYPDVLKFP 1038

  Fly  1220 DDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEFHRSSGPA--QQGDRFLPVMREFHAQASV 1282
            |::.||.:||:||...:.|::..::..::||.|:::    :.||  .:.|:|:..|..|...|..
Human  1039 DELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQ----NFPAATDEKDKFVEKMTSFVKDAQE 1099

  Fly  1283 RFAELEDKFQDMKTRFDRAVRLFGEDGSVLQPDEFFGIFDSFLAAFAEARHD--NESF------- 1338
            ::.:|.....:|:|.:......|..|...|..:|||....:|...|..::..  .|||
Human  1100 QYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLVSKGYLLTESFVGISHFP 1164

  Fly  1339 ------------------------------RRRQEEEEKR----AKQEAELKKRTIERKNKTGLM 1369
                                          :||:.||:.|    ||::||  |..:|::.|...:
Human  1165 LGSCWLVVGIQCPCVPSSSSLPQQAVKENQKRRETEEKMRRAKLAKEKAE--KERLEKQQKREQL 1227

  Fly  1370 TSVARNLGLKSGSSNGDPDSPAKGGDNKGEFDDLISALRTGDVFGEDMAKFKRSRKARVLN 1430
            ..:           |.:       ||..|..|.|:.||::|       |.|:|.|..|..|
Human  1228 IDM-----------NAE-------GDETGVMDSLLEALQSG-------AAFRRKRGPRQAN 1263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:283920	48/245 (20%)
		Drf_FH3	551..737	CDD:283917	57/193 (30%)
		FliJ	779..>875	CDD:280262	22/111 (20%)
		FH2	950..1328	CDD:280362	121/384 (32%)
DIAPH1	XP_024310152.1	Drf_GBD	84..268	CDD:310750	38/187 (20%)
		Drf_FH3	274..464	CDD:310747	65/230 (28%)
		SMC_N	<429..>570	CDD:330553	37/175 (21%)
		Drf_FH1	598..>700	CDD:283903	13/101 (13%)
		FH2	769..1145	CDD:280362	121/384 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950