Protein Alignment DAAM and Grid2ip

DIOPT Version :9

• Sequence 1: NP_001188522.1
• Gene: DAAM / 31075
• FlyBaseID: FBgn0025641
• Length: 1463
• Species: Drosophila melanogaster
• Sequence 2: NP_001152793.1
• Gene: Grid2ip / 170935
• MGIID: 2176213
• Length: 1203
• Species: Mus musculus
• Alignment Length: 517
• Identity: 143/517 - (27%)
• Similarity: 224/517 - (43%)
• Gaps: 96/517 - (18%)

  Fly   860 ISEQQERARLERLVTEGSIPDDQKVAGLTGCNGAVSPPPAPPMLKAIPPPPP------------- 911
            :|..:|.:.|    |..||.|.            :.|||..|     |||||
Mouse   723 VSSSEEGSSL----TYSSISDH------------IPPPPLSP-----PPPPPLPFHDPKPSSRTS 766

  Fly   912 ------------PMAPSMMPPPPPPCPGAPPPPPSMAQTMAPAPPKVDLPKKNVPQPTN--PLKS 962
                        |:.....|.||||.|..|||.|.       |||.:.....:....|:  .:|.
Mouse   767 DGPRGPPQSLTKPLTQINHPVPPPPPPPLPPPVPC-------APPMLSRGVGHRRSETSHMSVKR 824

  Fly   963 FNWSKLPDAKLQGTVWSELDESKLYNNMELESIDKLFSAYQKNGVSATDGSYEDLRV---TGKA- 1023
            ..|.::.::  :||:|.:|.|...|        |||....:          |.||.:   |.|.
Mouse   825 LRWEQVENS--EGTIWGQLGEDSDY--------DKLSDMVK----------YLDLELHFGTQKPP 869

  Fly  1024 ---------AKQKVLSVIDGRRAQNCTILLSKLKMSDMEISKAILSMDSNEQLQLDMVEQLLKFT 1079
                     .|::|:.::..::|.|.:|||:.||::..|:.:.::||:. .:|:...:.|||.|.
Mouse   870 KPVPGPEPFRKKEVVEILSHKKAYNTSILLAHLKLTPGELRQVLMSMEP-RRLEPAHLAQLLLFA 933

  Fly  1080 PSAEERALLDEHSEDIESLARADRFLYEISKIPHYEQRLKSLHYKKRFMLTINDLVPRITSVMEA 1144
            |.|:|........|....|:..|:|:.::..:|.|:.||:|||::........::...:..:.:|
Mouse   934 PDADEEQRYQAFREAPGRLSEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQA 998

  Fly  1145 SREVARSRRLRKLLELVLALGNYMNRG--ARGNASGFRLASLNRLADTKSSAAKGTTLLHYLVQV 1207
            |.|:..||:|.|:||.|||:|||:|.|  .....:||::..|..|..||:...| :|.||.|.:.
Mouse   999 SLELKNSRKLAKILEFVLAMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGK-STFLHILAKS 1062

  Fly  1208 IERKFKDLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEFHRSSGPAQQGDRFLPV 1272
            :.:.|.:||....|:|.|..|:||:...:..|:    ..|.|...||:....|......|||..|
Mouse  1063 LSQHFPELLGFAQDLPTVPLAAKVNQRALTGDL----ADLHDTVSEIQVACQSMAPSSEDRFAVV 1123

  Fly  1273 MREFHAQASVRFAELEDKFQDMKTRFDRAVRLFGEDGSVLQPDEFFGIFDSFLAAFAEARHD 1334
            |..|...|......|:...::......:|:..||||......:.|||||..|::.|..|..|
Mouse  1124 MASFLETAQPALRALDGLQREAMEELGKALAFFGEDSKATTSEAFFGIFSEFMSKFERALSD 1185

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:283920
		Drf_FH3	551..737	CDD:283917
		FliJ	779..>875	CDD:280262	3/14 (21%)
		FH2	950..1328	CDD:280362	110/394 (28%)
Grid2ip	NP_001152793.1	PDZ_signaling	9..69	CDD:238492
		HN_L-delphilin-R1_like	122..201	CDD:259820
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	215..270
		PDZ_signaling	269..342	CDD:238492
		HN_L-delphilin-R2_like	378..457	CDD:259821
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	466..541
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	563..586
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	611..656
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	710..821		31/125 (25%)
		FH2	812..1180	CDD:280362	110/393 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1922
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45725
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.940