Protein Alignment DAAM and Diaph1

DIOPT Version :10

• Sequence 1: NP_001188522.1
• Gene: DAAM / 31075
• FlyBaseID: FBgn0025641
• Length: 1463
• Species: Drosophila melanogaster
• Sequence 2: NP_001292909.1
• Gene: Diaph1 / 13367
• MGIID: 1194490
• Length: 1264
• Species: Mus musculus
• Alignment Length: 1310
• Identity: 347/1310 - (26%)
• Similarity: 550/1310 - (41%)
• Gaps: 318/1310 - (24%)

  Fly   325 KDDEPPEICVVEG------AFTLQTLTPTQPMPSVDELDTKFAELVEELDLTAPNKEAMLSLPAQ 383
            |...|.|:....|      .|||:.|       ..|||: :|..:..:.:...||.
Mouse    19 KGRSPDELPATGGDGGKHKKFTLKRL-------MADELE-RFTSMRIKKEKEKPNS--------- 66

  Fly   384 KKWQIYCSRKLPLDAADGPDAAAV------------------------TQPPTAEHYIERLKELV 424
                  ..|.......|.|.|.::                        .|.|..|..|...:|:|
Mouse    67 ------AHRNSSASYGDDPTAQSLQDISDEQVLVLFEQMLVDMNLNEEKQQPLREKDIVIKREMV 125

  Fly   425 ---VHISLS----PEDSPS-----HELGNRL-DGH-AAFVDALKTALRTSTHSFVLRFVELDGLP 475
               :|.|.:    .|.|.|     .||.:.| |.| .:.:::|:.:|..:..|:|..| ..:||.
Mouse   126 SQYLHTSKAGMNQKESSRSAMMYIQELRSGLRDMHLLSCLESLRVSLNNNPVSWVQTF-GAEGLA 189

  Fly   476 ALLDLLLQL-DIRVANSPLHTS-----LIGCIKALMNNSMGRAHVLAHPTAIDTIARSL--AADN 532
            :|||:|.:| |.:...|..:.|     :|.|:||.|||..|...:|.....|..:.|::  |..|
Mouse   190 SLLDILKRLHDEKEETSGNYDSRNQHEIIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPN 254

  Fly   533 IRTKIAALEILGAVCLVP---GGHRKVLQAMLHFQVFATERT------RFQSIVNDLDRSTYAYR 588
            :  .|.|.::|.|:|::|   ..:.:||:||       |||.      |||.:::.|...|
Mouse   255 M--MIDAAKLLSALCILPQPEDMNERVLEAM-------TERAEMDEVERFQPLLDGLKSGT---- 306

  Fly   589 DNVNLKTALMSFVNAVLNYGPGQENLEFRLHLRYEFLMLGIQPVIDKLRTHENETLDRHLDFFEM 653
             ::.||...:..:||::.  |.:| |:||:|:|.|.:.||:..|:.:||..|||.:...|..|:.
Mouse   307 -SIALKVGCLQLINALIT--PAEE-LDFRVHIRSELMRLGLHQVLQELREIENEDMKVQLCVFDE 367

  Fly   654 VRAEDEKEFARRFKEEHVDTKSAGSMFELLRRKLSHSPAYPHMLSLLQHMLLL--PYTGHCTEHW 716
            ...||..:...|..:..::....|.:|:::...:..|.|.||.||:|||:||:  .|... .:::
Mouse   368 QGDEDFFDLKGRLDDIRMEMDDFGEVFQIILNTVKDSKAEPHFLSILQHLLLVRNDYEAR-PQYY 431

  Fly   717 LLIDRVVQQIVLQVEQRPNSDLIVDPDDPEKQLKLAAESPVHDPDVAPLQIDVAKLVRLLVKEEQ 781
            .||:..|.||||....       .|||...:.                ||||:.:||..::.:.:
Mouse   432 KLIEECVSQIVLHKNG-------TDPDFKCRH----------------LQIDIERLVDQMIDKTK 473

  Fly   782 LTQARKRADELERE-------NFDVQSRLAKKEQELDLRMQ----EKEDLETGLARMRERLEKES 835
            :.::..:|.|||::       ..::|..:.|.|.:.:.::|    ||:.|::         ||:.
Mouse   474 VEKSEAKATELEKKLDSELTARHELQVEMKKMENDFEQKLQDLQGEKDALDS---------EKQQ 529

  Fly   836 AQHSQAVQRAQTAEMRAE--DLQHRLISEQQERARLERLVTEGSIPDDQKV---AGLTGCNGAVS 895
            ....:....|:.:::..|  .|...|...:.|.|.|..:|...|:.....|   ..|.|.:|.|.
Mouse   530 ITAQKQDLEAEVSKLTGEVAKLSKELEDAKNEMASLSAVVVAPSVSSSAAVPPAPPLPGDSGTVI 594

  Fly   896 PPPAPPML--------------------------------------------------------- 903
            |||.||..
Mouse   595 PPPPPPPPLPGGVVPPSPPLPPGTCIPPPPPLPGGACIPPPPQLPGSAAIPPPPPLPGVASIPPP 659

  Fly   904 ------------------------------KAIPPPPPPMAPSM-------------MPPPPPPC 925
                                          ..|||||||:..|:             :||||||.
Mouse   660 PPLPGATAIPPPPPLPGATAIPPPPPLPGGTGIPPPPPPLPGSVGVPPPPPLPGGPGLPPPPPPF 724

  Fly   926 PGA---PPPPPSMAQTMAPAPP-----------KVDLPKKNVPQPTNPLKSFNWSKLPDAKL-QG 975
            |||   |||||.|.  :.|.||           ...|..|.|.:|...|:..||||.....| |.
Mouse   725 PGAPGIPPPPPGMG--VPPPPPFGFGVPAAPVLPFGLTPKKVYKPEVQLRRPNWSKFVAEDLSQD 787

  Fly   976 TVWSELDESKLYNNMELESIDKLFSAYQKNGVSATD--GSYEDLRVTGKAAKQKVLSVIDGRRAQ 1038
            ..|:::.|.:..||.....:...|||..|...:..|  |..|...|..|  |.|.|.|:|.:.||
Mouse   788 CFWTKVKEDRFENNELFAKLTLAFSAQTKTSKAKKDQEGGEEKKSVQKK--KVKELKVLDSKTAQ 850

  Fly  1039 NCTILLSKLKMSDMEISKAILSMDSNEQ-LQLDMVEQLLKFTPSAEERALLDEHSEDIESLARAD 1102
            |.:|.|...:|...||...||.:  ||. |...|::.|:|..|..|:..:|.|..|:.:.||.::
Mouse   851 NLSIFLGSFRMPYQEIKNVILEV--NEAVLTESMIQNLIKQMPEPEQLKMLSELKEEYDDLAESE 913

  Fly  1103 RFLYEISKIPHYEQRLKSLHYKKRFMLTINDLVPRITSVMEASREVARSRRLRKLLELVLALGNY 1167
            :|...:..:|....||.::.:|.:|...:.::.|.|.||..|..|:.:|.....||||.|.:|||
Mouse   914 QFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSENFSSLLELTLLVGNY 978

  Fly  1168 MNRGAR-GNASGFRLASLNRLADTKSSAAKGTTLLHYLVQVIERKFKDLLKLEDDIPHVREASKV 1231
            ||.|:| ..|.||.::.|.:|.||||:..| .||||:|.::.|....::||..|::.||.:||:|
Mouse   979 MNAGSRNAGAFGFNISFLCKLRDTKSADQK-MTLLHFLAELCENDHPEVLKFPDELAHVEKASRV 1042

  Fly  1232 SLGEMDKDIQMLRTGLADVAREIEFHRSSGPA--QQGDRFLPVMREFHAQASVRFAELEDKFQDM 1294
            |...:.|.:..::..:|||.|:::    :.||  .:.|:|:..|..|...|..::.:|.....:|
Mouse  1043 SAENLQKSLDQMKKQIADVERDVQ----NFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNM 1103

  Fly  1295 KTRFDRAVRLFGEDGSVLQPDEFFGIFDSFLAAFAEARHDNESFRRRQEEEEKR----AKQEAEL 1355
            :|.:......|..|...|..:|||....:|...|.:|..:|:  :||:.||:.|    ||::||
Mouse  1104 ETLYKELGDYFVFDPKKLSVEEFFMDLHNFRNMFLQAVKENQ--KRRETEEKMRRAKLAKEKAE- 1165

  Fly  1356 KKRTIERKNKTGLMTSVARNLGLKSGSSNGDPDSPAKGGDNKGEFDDLISALRTGDVFGEDMAKF 1420
             |..:|::.|...:..:           |.:       ||..|..|.|:.||::|       |.|
Mouse  1166 -KERLEKQQKREQLIDM-----------NAE-------GDETGVMDSLLEALQSG-------AAF 1204

  Fly  1421 KRSRKARVLN 1430
            :|.|..|.:|
Mouse  1205 RRKRGPRQVN 1214

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:461886	58/244 (24%)
		Drf_FH3	551..737	CDD:461885	58/193 (30%)
		Smc	<765..>875	CDD:440809	27/122 (22%)
		FH2	950..1328	CDD:396655	123/384 (32%)
Diaph1	NP_001292909.1	Drf_GBD	88..268	CDD:461886	48/182 (26%)
		Drf_FH3	274..464	CDD:461885	65/228 (29%)
		SMC_prok_B	<429..>564	CDD:274008	34/166 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	576..746		36/171 (21%)
		FH2	761..1137	CDD:396655	123/384 (32%)