Protein Alignment DAAM and dia

DIOPT Version :10

• Sequence 1: NP_001188522.1
• Gene: DAAM / 31075
• FlyBaseID: FBgn0025641
• Length: 1463
• Species: Drosophila melanogaster
• Sequence 2: XP_061518216.1
• Gene: dia / 1279020
• VectorBaseID: AGAMI1_005236
• Length: 1118
• Species: Anopheles gambiae
• Alignment Length: 1168
• Identity: 317/1168 - (27%)
• Similarity: 517/1168 - (44%)
• Gaps: 215/1168 - (18%)

  Fly   355 ELDTKFAELVEELDLTAPNKEAMLSLPAQKKWQIYCSRKLPLDAADGPDAAAVTQPPTAEHYIER 419
            |::..|.|::|::::....::.:|..|.::|      ||:    .|......::....|....|:
Mosquito    83 EVNKLFLEILEDMNIPKDKRDPLLGKPLEEK------RKM----IDMHVKGKISSEHRANSRFEK 137

  Fly   420 LKELVVHISLSPEDSPSHELG---NRLDGHAAFVDALKTALRTSTHSFVLRFVELDGLPALLDLL 481
            ..:.|.::         || |   ||.:...|.:::|:.||.::..|::..|.| ||:..::.||
Mosquito   138 PSDYVQYL---------HE-GDYLNRTNKLLACLESLRVALTSNPISWIKDFGE-DGINEIVSLL 191

  Fly   482 LQLDIRVANSPLHT---SLIGCIKALMNNSMGRAHVLAHP---TAIDTIARSLAADNIRTKIAAL 540
            ..  .:.....:|.   ..:.|:||::|||.| .:|:..|   ..:..:|:.:......|...|:
Mosquito   192 RY--CKTVPRRMHKIEYECLRCLKAILNNSWG-LNVILTPDQHAVVLLLAQCIDTTQPHTMCEAI 253

  Fly   541 EILGAVCLVP--GGHRKVLQAMLHFQVF---ATERTR--FQSIVNDLDRSTYAYRDNVNLKTALM 598
            ::|.|:.|:.  .|:.|||:|:.:....   ..||.|  .:.::.|.||       |..|..:.|
Mosquito   254 KLLSALTLLKDRNGYEKVLRAITNVSSMRKPGAERFRPIVEGLLMDNDR-------NYELTCSTM 311

  Fly   599 SFVNAVLNYGPGQENLEFRLHLRYEFLMLGIQPVIDKLRTH----ENETLDRHLDFFEMVRAEDE 659
            .|:|.::|   ...::.||||||.|.:..|:...||:|...    .||.|..|:..|...|.||.
Mosquito   312 IFINCIIN---TPTDINFRLHLRCEIMRAGLYERIDQLSEMVDKCGNENLVNHIKIFNSYREEDF 373

  Fly   660 KEFARRFKEEHVDTKSAGSMFELLRRKLSHSPAYPHMLSLLQHMLLL----PYTGHCTEHWLLID 720
            :||:.||....::.......||||:..::.:.:.|:.||:|||:|.:    .|.   ..::.||:
Mosquito   374 EEFSNRFDNVRLELDDMNDCFELLKNLVADTASEPYFLSILQHLLFIRDDHQYR---PAYFKLIE 435

  Fly   721 RVVQQIVLQVEQRPNSDLIVDPDDPEKQLKLAAESPVHDP--DVAPLQIDVAKLVRLLVKEEQLT 783
            ..|.||||                         ....:||  |.....||.:.|:
Mosquito   436 ECVSQIVL-------------------------HKSGYDPNFDSRDFHIDTSTLL---------- 465

  Fly   784 QARKRADELERENFDVQSRLAKKEQELDLRMQE----KEDLETGLARMRERLEKESAQHSQAVQR 844
                  |::..:...::|   ||.::.:.||.|    |::.|..:|.:.:||::..|.
Mosquito   466 ------DDMAEKTKQIES---KKSEDFEKRMTELQTAKQEAEARVAALEDRLKEIEAT------- 514

  Fly   845 AQTAEMRAEDLQHRLISEQQERARLERLVTEGSIPDDQKVAGLTGCNGAVSPPPAP---PMLK-- 904
                         .::...:.:::|.::......|      ||....|...|||.|   |::.
Mosquito   515 -------------GVVVSPKGKSKLPQITIPPPPP------GLLPGGGPPPPPPCPGAVPVMMGG 560

  Fly   905 ---AIPPPPPPMAPSMM---PPPPPPCP--GAPPPPPSMAQTMAPAPPKVDLPKKN-VPQP---- 956
               ..||||||..|...   ||||||.|  |.|||||.....|...||.:..|..| .|:|
Mosquito   561 GGGGAPPPPPPPFPGAAAGGPPPPPPMPGMGGPPPPPPPMMMMGMRPPGMPPPFPNAAPKPLPYG 625

  Fly   957 ---------TNPLKSFNWSKLPDAK--LQGTVWSELDESKLYNNMELESIDKLFSAYQKNGVSAT 1010
                     ..|:|..||:.| |||  .:.:.|.::.|.:|.:|.....:...||:.....:.
Mosquito   626 LKPKKKWDTDGPMKRANWNGL-DAKNLSENSFWVQVQEEQLADNDMFARLALKFSSKPAKPID-- 687

  Fly  1011 DGSYEDLRVTGKAAKQKV-LSVIDGRRAQNCTILL-SKLK-MSDMEISKAILSMDSNEQLQLDMV 1072
                :|.....:::|:.| |.|:|.:.|||.:||| ..|| :|..:|...:|..|:: .|...::
Mosquito   688 ----KDAADRPQSSKKNVDLRVLDAKAAQNLSILLGGSLKHLSHEQIRTCLLRCDTS-VLSPSVL 747

  Fly  1073 EQLLKFTPSAEERALLDEHSEDIESLARADRFLYEISKIPHYEQRLKSLHYKKRFMLTINDLVPR 1137
            :||:::.|..::...|.|.....|.||.|:||...|..|.....||:||.:|......:.|:.|.
Mosquito   748 QQLIQYLPPPDQLKRLQEIRARGEDLAGAERFAATIGDIKRLGARLQSLSFKIDLPDMVQDVKPD 812

  Fly  1138 ITSVMEASREVARSRRLRKLLELVLALGNYMNRGARGN-ASGFRLASLNRLADTKSSAAKGTTLL 1201
            |.:...|..||..|::..|:|||:|.||||||.|::.: |.||.::.|.:|:.||....| .|||
Mosquito   813 IVAGTAACEEVKTSKKFAKVLELILLLGNYMNSGSKKDPAYGFEMSFLPKLSSTKDHENK-QTLL 876

  Fly  1202 HYLVQVIERKFKDLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEFHRSSGPAQQG 1266
            |||.:|||.||.:.|...:|:.||.:||:|||..:.|.::.:...|.::  |.:.:.:..|..:.
Mosquito   877 HYLAEVIESKFPEALTFYEDLSHVDKASRVSLDTIQKTMRQMNNALKNL--ESDLNNNKVPQSED 939

  Fly  1267 DRFLPVMREFHAQASVRFAELEDKFQDMKTRFDRAVRLFGEDGSVLQPDEFFGIFDSFLAAFAEA 1331
            ||||.||.:|..:...:...|......|::.|......:..|.:....:|||....:|..||.:|
Mosquito   940 DRFLDVMGQFAVECRAQVEVLGRMLAQMESLFGSLSEYYCFDPAKYTMEEFFTDIKTFKDAFVQA 1004

  Fly  1332 RHDNESFRRRQEEEEKRAKQEAELKKRTIERKNKTGLMTSVARNLGLKSGSSNGDPDSPAKGGDN 1396
            ..||  .|.|:|||:||..|||:      ||..:..|.....|.:.|    .|.|     .....
Mosquito  1005 HADN--CRLREEEEKKRRAQEAK------ERSQRELLERQQQRKVDL----INID-----AAQTQ 1052

  Fly  1397 KGEFDDLISALRTGDVFGEDMAKFKRSRKARVLNGGGSSTGHTSPPRHGSLQREESGRERERT 1459
            :|..|.|:.||:||..||.     :..|:.|            .|...|:.:|.:..|.|.||
Mosquito  1053 EGVMDSLLEALQTGSAFGN-----REQRRRR------------GPRPAGAERRAQLNRSRSRT 1098

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:461886	44/201 (22%)
		Drf_FH3	551..737	CDD:461885	59/198 (30%)
		Smc	<765..>875	CDD:440809	17/113 (15%)
		FH2	950..1328	CDD:396655	120/397 (30%)
dia	XP_061518216.1	None