Protein Alignment DAAM and DAAM

DIOPT Version :10

• Sequence 1: NP_001188522.1
• Gene: DAAM / 31075
• FlyBaseID: FBgn0025641
• Length: 1463
• Species: Drosophila melanogaster
• Sequence 2: XP_061497016.1
• Gene: DAAM / 1269191
• VectorBaseID: AGAMI1_014762
• Length: 1286
• Species: Anopheles gambiae
• Alignment Length: 1280
• Identity: 925/1280 - (72%)
• Similarity: 1038/1280 - (81%)
• Gaps: 66/1280 - (5%)

  Fly   212 RSSSANDNGGGSDQQQSQSNHENGLGSEAGSFYTHNILGYTFGYPFGLKEDLDGSGNCNSNCNGS 276
            :.:..|..|..:..:.:..|:.:.:.:.|.:||.                        .:...||
Mosquito    45 KEAVTNSGGSTTTPEGTSGNYSSNITATADAFYQ------------------------PTTVPGS 85

  Fly   277 SNT----NGLGLRKWLSGNTSSNETPLQKHYRHQQKKKMPGFRGRRVWCGCFKDDEPPEICVVEG 337
            .:|    ||..:....:.....::|.|.|||:  ..||||.|||||.||||.:||||||||||||
Mosquito    86 LHTVVPANGTAVTVQPTAQQHYHQTNLHKHYK--AHKKMPAFRGRRGWCGCLQDDEPPEICVVEG 148

  Fly   338 AFTLQTLTPTQPMPSVDELDTKFAELVEELDLTAPNKEAMLSLPAQKKWQIYCSRKLPLDAADGP 402
            .|:|||||||||||::||||:||||||||||||||||.||:|||.|||||||||||.|||:  ||
Mosquito   149 VFSLQTLTPTQPMPAIDELDSKFAELVEELDLTAPNKAAMMSLPPQKKWQIYCSRKSPLDS--GP 211

  Fly   403 DAAAV-TQPPTAEHYIERLKELVVHI-SLSPEDSPSHELGNRLDGHAAFVDALKTALRTSTHSFV 465
            :...: |.||:.||||||||::.|.: :.:|::||:||.|.:::...|..||||||||||.||||
Mosquito   212 NGTPLQTVPPSPEHYIERLKDMAVQLKACAPDESPTHEYGPKIESQTALFDALKTALRTSAHSFV 276

  Fly   466 LRFVELDGLPALLDLLLQLDIRVANSPLHTSLIGCIKALMNNSMGRAHVLAHPTAIDTIARSLAA 530
            :||:||.||||||:||..|||||||||||||||||||||||||.||:|||||||.||||||||||
Mosquito   277 IRFIELQGLPALLELLQALDIRVANSPLHTSLIGCIKALMNNSTGRSHVLAHPTGIDTIARSLAA 341

  Fly   531 DNIRTKIAALEILGAVCLVPGGHRKVLQAMLHFQVFATERTRFQSIVNDLDRSTYAYRDNVNLKT 595
            |||:|||||||||||||||||||:|||.|||::|.:|.||.|||.|||||||||.||||:|||||
Mosquito   342 DNIKTKIAALEILGAVCLVPGGHKKVLNAMLNYQEYAAERARFQGIVNDLDRSTGAYRDDVNLKT 406

  Fly   596 ALMSFVNAVLNYGPGQENLEFRLHLRYEFLMLGIQPVIDKLRTHENETLDRHLDFFEMVRAEDEK 660
            |:|||:||||||||||||||||||||||||||||||||||||.|||:||:||||||||||.||||
Mosquito   407 AIMSFINAVLNYGPGQENLEFRLHLRYEFLMLGIQPVIDKLRKHENDTLNRHLDFFEMVRNEDEK 471

  Fly   661 EFARRFKEEHVDTKSAGSMFELLRRKLSHSPAYPHMLSLLQHMLLL--PYTGHCTEHWLLIDRVV 723
            |.||:|..||||||||.:||:|:||||||||||||:||||||||||  |.||...:||||.||||
Mosquito   472 ELARKFDHEHVDTKSASAMFDLIRRKLSHSPAYPHLLSLLQHMLLLPPPTTGPNAQHWLLFDRVV 536

  Fly   724 QQIVLQVEQRPNSDLIVDPDDP------EKQLKLAAESPVHDPDVAPLQIDVAKLVRLLVKEEQL 782
            ||:|||.|:||.||.: |||.|      |.....:|...:.|||||||.|||.|:|:||||||:|
Mosquito   537 QQLVLQHEERPASDCL-DPDAPGADKRSETGSVASASLKLQDPDVAPLAIDVRKVVKLLVKEEEL 600

  Fly   783 TQARKRADELERENFDVQSRLAKKEQELDLRMQEKEDLETGLARMRERLEKESAQHSQAVQRAQT 847
            ..||.||::|||||.::.:|||||||:||.|.||||||||.|||||||||||||.||||||||..
Mosquito   601 VAARTRAEDLERENAEIVARLAKKEQDLDHRTQEKEDLETALARMRERLEKESANHSQAVQRALN 665

  Fly   848 AEMRAEDLQHRLISEQQERARLERLVTEGSIPDDQKVAGLTG--CNG-AVSPPPAPPMLKAIPPP 909
            |||||||||||::||||||.||||||||||||||||||||.|  ||| |.||||.||....:|||
Mosquito   666 AEMRAEDLQHRIVSEQQERLRLERLVTEGSIPDDQKVAGLQGANCNGQATSPPPPPPPACKLPPP 730

  Fly   910 PPPMAPSMMP--PPPPPCPGAPPPPPSMAQTMAPAPPKV-DLPKKNVPQPTNPLKSFNWSKLPDA 971
            |||  |.|||  |||||.||..|.........|||.||. :.||||||||.|||||||||||||:
Mosquito   731 PPP--PMMMPAAPPPPPAPGGLPKVAPAGGPQAPAAPKAPEAPKKNVPQPANPLKSFNWSKLPDS 793

  Fly   972 KLQGTVWSELDESKLYNNMELESIDKLFSAYQKNGVS-ATDGSYEDLRVTGKAAKQKVLSVIDGR 1035
            |||||||||||::|.||::|||||||||||||||||: :.|||.||||:.|| .|.|:|||||||
Mosquito   794 KLQGTVWSELDDTKWYNSIELESIDKLFSAYQKNGVAVSNDGSIEDLRLIGK-NKAKILSVIDGR 857

  Fly  1036 RAQNCTILLSKLKMSDMEISKAILSMDSNEQLQLDMVEQLLKFTPSAEERALLDEHSEDIESLAR 1100
            ||||||||||||||:|.|||||||||||||||.:||||||||||||||||||||||||||:||||
Mosquito   858 RAQNCTILLSKLKMTDEEISKAILSMDSNEQLPIDMVEQLLKFTPSAEERALLDEHSEDIDSLAR 922

  Fly  1101 ADRFLYEISKIPHYEQRLKSLHYKKRFMLTINDLVPRITSVMEASREVARSRRLRKLLELVLALG 1165
            ||||||||||||||||||:||||||||.:|:|||.|||.|||||||||||||:||||||||||||
Mosquito   923 ADRFLYEISKIPHYEQRLRSLHYKKRFQVTVNDLAPRIASVMEASREVARSRKLRKLLELVLALG 987

  Fly  1166 NYMNRGARGNASGFRLASLNRLADTKSSAAKGTTLLHYLVQVIERKFKDLLKLEDDIPHVREASK 1230
            |||||||||||||||||||||||||||||||||||||||||:||:||||:|.||:|:|||:||||
Mosquito   988 NYMNRGARGNASGFRLASLNRLADTKSSAAKGTTLLHYLVQIIEKKFKDILTLEEDLPHVKEASK 1052

  Fly  1231 VSLGEMDKDIQMLRTGLADVAREIEFHRSSGPAQQGDRFLPVMREFHAQASVRFAELEDKFQDMK 1295
            ||||||||||.|||.|||:|.||||||||||.:|.||||||||||||||||||||||||:|||||
Mosquito  1053 VSLGEMDKDITMLRAGLAEVNREIEFHRSSGASQPGDRFLPVMREFHAQASVRFAELEDQFQDMK 1117

  Fly  1296 TRFDRAVRLFGEDGSVLQPDEFFGIFDSFLAAFAEARHDNESFRRRQEEEEKRAKQEAELKKRTI 1360
            ||||||||||||||||:||:|||||||.||:|..||:.|||:|||||||||||||||||||||||
Mosquito  1118 TRFDRAVRLFGEDGSVVQPEEFFGIFDGFLSALMEAKQDNENFRRRQEEEEKRAKQEAELKKRTI 1182

  Fly  1361 ERKNKTGLMTSVARNLGLKSGSSNGDPDSPAKGGD--NKGEFDDLISALRTGDVFGEDMAKFKRS 1423
            |||:|.||:.|||..|||||..|||....|..|.|  ||||||||||||||||||||||||||||
Mosquito  1183 ERKSKEGLLNSVAGKLGLKSKHSNGTNGGPVPGADPNNKGEFDDLISALRTGDVFGEDMAKFKRS 1247

  Fly  1424 RKARVLNGGGSSTGHTSPPR-HGSLQREESGRERERT----VRRQ 1463
            ||.|:   |.:.|.:||||| ..|:.||:|   ||||    .|||
Mosquito  1248 RKTRL---GPNGTNNTSPPRSRNSIGREDS---RERTGVANNRRQ 1286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:461886	148/200 (74%)
		Drf_FH3	551..737	CDD:461885	149/187 (80%)
		Smc	<765..>875	CDD:440809	84/109 (77%)
		FH2	950..1328	CDD:396655	329/378 (87%)
DAAM	XP_061497016.1	None