DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAAM and FMNL2

DIOPT Version :9

Sequence 1:	NP_001188522.1	Gene:	DAAM / 31075	FlyBaseID:	FBgn0025641	Length:	1463	Species:	Drosophila melanogaster
Sequence 2:	XP_011508832.1	Gene:	FMNL2 / 114793	HGNCID:	18267	Length:	1099	Species:	Homo sapiens

Alignment Length:	1276	Identity:	319/1276 - (25%)
Similarity:	536/1276 - (42%)	Gaps:	377/1276 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   349 PMPSVDELDTKFAELVEELDLTAPNKEAML-SLPAQKKWQIYCSRKLPLDAADGPDAAAVTQPPT 412
            |||...||:.:||.::..::| .|:|..:| ....:|||::.|.:          :...|..||
Human    24 PMPEPGELEERFAIVLNAMNL-PPDKARLLRQYDNEKKWELICDQ----------ERFQVKNPP- 76

  Fly   413 AEHYIERLKELVVHISLSPEDSPSHELGNRLDGHAAFVDALKTALRTSTHSFVLRFV--ELDGLP 475
             ..||::||..     |.|..: ..:...|:......:..|:.:|||:...:|..|:  |..||.
Human    77 -HTYIQKLKGY-----LDPAVT-RKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENKGLD 134

  Fly   476 ALLDLL------LQLDIR------------------------------------VANSPLHTSL- 497
            .|::.|      :..|..                                    |:.|..|::|
Human   135 VLVEYLSFAQYAVTFDFESVESTVESSVDKSKPWSRSIEDLHRGSNLPSPVGNSVSRSGRHSALR 199

  Fly   498 -------------------------IGCIKALMNNSMGRAHVLAHPTAIDTIARSLAADNIRTKI 537
                                     |.|::|:||...|...|::||.|::.||.||...|.|||.
Human   200 YNTLPSRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKA 264

  Fly   538 AALEILGAVCLVPGGHRKVLQAMLHFQVFATERTRFQSIVNDLDRSTYAYRDNVNLKTALMSFVN 602
            ..||:|.|||||.|||..:|.|..:|:....|:.||:.::.......    :|::...|.|.|:|
Human   265 LVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFEKLMEHFRNED----NNIDFMVASMQFIN 325

  Fly   603 AVLNYGPGQENLEFRLHLRYEFLMLGIQPVIDKLRTHENETLDRHLDFFEMVRAEDEKEFARRFK 667
            .|::   ..|::.||:||:|||..||:...:|||:..|::.|.      ..::|..:..|.....
Human   326 IVVH---SVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQ------VQIQAYLDNVFDVGAL 381

  Fly   668 EEHVDTKSAG-SMFELLRRKLSHSPAYPHMLSLLQHMLLLPYTGHCTEHWLLIDRVVQQIVLQVE 731
            .|..:||:|. ...|.|...:||                            |.:::
Human   382 LEDAETKNAALERVEELEENISH----------------------------LSEKL--------- 409

  Fly   732 QRPNSDLIVDPDDPEKQLKLAAESPVHDPDVAPLQIDVAKLVRLLVKEEQLTQARKRADELEREN 796
                       .|.|.:.                   ::|:|.|   |:||.|..|
Human   410 -----------QDTENEA-------------------MSKIVEL---EKQLMQRNK--------- 432

  Fly   797 FDVQSRLAKKEQELDLRMQEKEDLETGLARMRERL-EKESAQHSQAVQRAQTAEMRAEDLQHRLI 860
                        |||:..:..:|..|.:..:|:.: |||     :|:||..|.|.:..:|
Human   433 ------------ELDVVREIYKDANTQVHTLRKMVKEKE-----EAIQRQSTLEKKIHEL----- 475

  Fly   861 SEQQERARLER----------LVTEGSIP-DDQKVAGLT-------GCNGAVSPPPAP------- 900
             |:|...::::          :|..|::. ..:.|||.:       ..:|.:.|||.|
Human   476 -EKQGTIKIQKKGDGDIAILPVVASGTLSMGSEVVAGNSVGPTMGAASSGPLPPPPPPLPPSSDT 539

  Fly   901 -------PMLKAIPPPPPPMAPSMMPPPPPPCPGAPPPPP---SMAQTMAPAPPKVDLPKKNVP- 954
                   |:...:||||||      ||||||.|..|||||   ..|:|: ||||... |..:.|
Human   540 PETVQNGPVTPPMPPPPPP------PPPPPPPPPPPPPPPLPGPAAETV-PAPPLAP-PLPSAPP 596

  Fly   955 -----QPT--------------------NPLKS------FNWSKLPDAKLQGTVWSELDESKLYN 988
                 .||                    .|:|:      |||..|...::.|||::|:|:.::..
Human   597 LPGTSSPTVVFNSGLADGPIKLFSVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILE 661

  Fly   989 NMELESIDKLFSAYQKNGVSATDGSYEDLRVTGKAAKQKV-------LSVIDGRRAQNCTILLSK 1046
            ::.::..:::|.       :...|...||    .::|||:       :::::..||:|..|.|.|
Human   662 DLNVDEFEEIFK-------TKAQGPAIDL----SSSKQKIPQKGSNKVTLLEANRAKNLAITLRK 715

  Fly  1047 LKMSDMEISKAILSMDSNEQLQLDMVEQLLKFTPSAEERALL---DEHSEDIESLARADRFLYEI 1108
            ...:..||.|||...|. :.|.:|.||.|::|.|:..|..:|   :...:.:|:|:..|||:.:.
Human   716 AGKTADEICKAIHVFDL-KTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQF 779

  Fly  1109 SKIPHYEQRLKSLHYKKRFMLTINDLVPRITSVMEASREVARSRRLRKLLELVLALGNYMNRGAR 1173
            |||....|::..:.:...|..:|..|.|::.:::.||..:..|::|:|:||::||||||||...|
Human   780 SKIERLMQKMTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKR 844

  Fly  1174 GNASGFRLASLNRLADTKSSAAKGTTLLHYLVQVIERKFKDLLKLEDDIPHVREASKVSLGEMDK 1238
            |...||:|.||:.|.||||:..| .|||||:..|::.|:..:....:::.:|.:|:.|||..:..
Human   845 GAVYGFKLQSLDLLLDTKSTDRK-QTLLHYISNVVKEKYHQVSLFYNELHYVEKAAAVSLENVLL 908

  Fly  1239 DIQMLRTGLADVAREIEFHRSSGPAQQGDRFLPVMREFHAQASVRFAELEDKFQDMKTRFDRAVR 1303
            |::.|:.|:....||...|..:          .:::||......:..:|:|..:..:..||..|:
Human   909 DVKELQRGMDLTKREYTMHDHN----------TLLKEFILNNEGKLKKLQDDAKIAQDAFDDVVK 963

  Fly  1304 LFGEDGSVLQPDEFFGIFDSFLAAFAEARHDNESFRRRQEEE--EKRAKQEAELKKRTIERKNKT 1366
            .|||:.....|..||.:|..|:.|:.:|..:|| .|::||:.  ||..:|||.::::
Human   964 YFGENPKTTPPSVFFPVFVRFVKAYKQAEEENE-LRKKQEQALMEKLLEQEALMEQQ-------- 1019

  Fly  1367 GLMTSVARNLGLKSGSSNGDPDSPAKGGDNKGEFDDLISALRTGDVFGEDMAKFKRSRKARVLNG 1431
                               ||.||:.  .:|.:..:||:.||...|        |.:|
Human  1020 -------------------DPKSPSH--KSKRQQQELIAELRRRQV--------KDNR------- 1048

  Fly  1432 GGSSTGHTSPPRHGSLQ------REESGRERE---RTVRRQ 1463
                  |....:.|:::      |.:..|..:   |:|||:
Human  1049 ------HVYEGKDGAIEDIITDLRNQPYRRADAVRRSVRRR 1083

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:283920	64/269 (24%)
		Drf_FH3	551..737	CDD:283917	41/186 (22%)
		FliJ	779..>875	CDD:280262	23/106 (22%)
		FH2	950..1328	CDD:280362	116/419 (28%)
FMNL2	XP_011508832.1	Drf_GBD	23..275	CDD:283920	64/269 (24%)
		Drf_FH3	278..475	CDD:283917	65/305 (21%)
		FH2	623..974	CDD:280362	108/373 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54599
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950