DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAAM and LOC101886015

DIOPT Version :9

Sequence 1:	NP_001188522.1	Gene:	DAAM / 31075	FlyBaseID:	FBgn0025641	Length:	1463	Species:	Drosophila melanogaster
Sequence 2:	XP_021336758.1	Gene:	LOC101886015 / 101886015	-ID:	-	Length:	1224	Species:	Danio rerio

Alignment Length:	1258	Identity:	326/1258 - (25%)
Similarity:	560/1258 - (44%)	Gaps:	222/1258 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   339 FTLQTLTPTQPMPSVDELDTKFAEL----VEELDLTAPNKEAMLSLPAQKKWQIYCSRKLPLDAA 399
            |||:.|.|       |||: :|..:    .:|...|..|:.:     :..:::|
Zfish    34 FTLKRLIP-------DELE-RFTSMRTKKEKEKSSTMGNRHS-----SAAQYEI----------- 74

  Fly   400 DGPDAAAVTQPPTAEHYIERLKELVVHISLSPE--------------DSPSHELGNRLDG----- 445
              |..::.....:.||.:|..::::|.::|:.|              :..|..|.....|
Zfish    75 --PSQSSSLHELSDEHVLELFEQMLVDMNLNEEKQRPLRQKDIMIKREMVSQYLHTSTAGKNQKE 137

  Fly   446 --HAAFV------------------DALKTALRTSTHSFVLRFVELDGLPALLDLLLQL-DIRVA 489
              .:|.|                  ::|:.:|..:..|:|..|.:.|||..||..|.:| |.|
Zfish   138 SSKSALVYIQELKADLKDTQLLSCLESLRVSLNNNPVSWVQTFGDGDGLDLLLKFLRKLQDER-- 200

  Fly   490 NSPLH--------TSLIGCIKALMNNSMGRAHVLAHPTAIDTIARSLAADNIRTKIAALEILGAV 546
            ..||:        ..:|.|:||.|||..|...:|.....|..:.||:..|.....:..:.:|.|:
Zfish   201 EEPLNGGIGVKCQHEIIRCLKAFMNNKHGLKAMLMSAEGIPLLVRSINPDVQHMMVDVVRLLSAI 265

  Fly   547 CLV--PGG-HRKVLQAMLHFQVFATERTRFQSIVNDLDRSTYAYRDNVNLKTALMSFVNAVLNYG 608
            |::  |.. |.:||:.:.. |....:..|||.:::.:.      ::::.||...|..:||:::
Zfish   266 CILDHPDNIHERVLECITE-QAEEHDIERFQPLLSGMQ------KNSITLKAGCMQLINALIS-- 321

  Fly   609 PGQENLEFRLHLRYEFLMLGIQPVIDKLRTHENETLDRHLDFFEMVRAEDEKEFARRFKEEHVDT 673
             ..|.|:||:|||.|...||::.::..:|..|||.|...|..|:....||.::...|..:..::.
Zfish   322 -RVEELDFRIHLRSELSRLGLRDMLKDVRAIENEELKVQLQVFDEQADEDTEDLRARLDDIRIEM 385

  Fly   674 KSAGSMFELLRRKLSHSPAYPHMLSLLQHMLLL--PYTGHCTEHWLLIDRVVQQIVLQVEQRPNS 736
            .....:|::|...:..|.|.|..||||||:||:  .|... .:::.|||....||||....
Zfish   386 DDVTEVFQILVNTVKDSKAEPLFLSLLQHLLLVRNDYMSR-PQYYKLIDECTAQIVLHKNG---- 445

  Fly   737 DLIVDPDDPEKQLKLAAESPVHD-PDVAPLQIDVAKLVRLLVK-EEQLTQARKRADELERENFDV 799
               .|||...::.:|.....:.: .|...::|..||...|..| :.:||..::...||::...|.
Zfish   446 ---CDPDFKCRKFELEVGHLIDNMVDQTKVEISEAKATELEKKLDAELTARQELQVELKKLEADY 507

  Fly   800 QSRL----AKKE---QELDLRMQEKEDLETGLARMRERLEKESAQHSQAVQRAQTAEMRAEDLQH 857
            :.:|    |:||   :|...:.:|.:.:::.:..::|::||.|....:|..:..|..:....
Zfish   508 EQKLLDLSAEKETLGKEKGEQEKENKVMQSEINLLKEKIEKLSKDLKEAKAKVITVHVPVAP--- 569

  Fly   858 RLISEQQERARLER----LVTEGSIPDDQKVAGLTGCNGAVSPPPAPPMLKA--IPPPPPPM--- 913
               ..:...|.|..    |....::|.......|.|..|...|||.||:..|  :||||||:
Zfish   570 ---PPRPGEASLPTPPPPLPGHTAMPHPPPPPPLPGGPGFPPPPPPPPLPGAAGMPPPPPPLPGA 631

  Fly   914 --------APSM-----MPPPPPPCPGA------PPPPPSMAQTMAP------------------ 941
                    .|.:     :||||||.||.      |||||.||....|
Zfish   632 AGFPPPPPPPPLPGGPGLPPPPPPLPGGPGMPPPPPPPPGMAGMPPPPPPMGGPGMPPPPPFGGW 696

  Fly   942 APPKVDL-----PKKNVPQPTNPLKSFNWSKL-PDAKLQGTVWSELDESKLYNNMEL-ESIDKLF 999
            |||...|     |||:. :|...:|..||||: |:...:|:.|.:..|.: |.:.|| ..:...|
Zfish   697 APPVPQLPFGLQPKKDY-KPEVQMKRANWSKISPEDLSEGSFWVKAKEDR-YEDKELFAKLTLAF 759

  Fly  1000 SAYQKNGVSATDGSYEDLRVTGKAAKQKVLSVIDGRRAQNCTILLSKLKMSDMEISKAILSMDSN 1064
            |...|...:..|....:.:.:.:..|.|.|.|:|.:.:||.:|.|...::...|:...||.:  |
Zfish   760 STQTKTSKAKKDQEASEEKKSAQKKKVKELKVLDSKTSQNLSIFLGSNRLPYEEMKTVILEV--N 822

  Fly  1065 EQLQLD-MVEQLLKFTPSAEERALLDEHSEDIESLARADRFLYEISKIPHYEQRLKSLHYKKRFM 1128
            |.|..: ||:.|||..|..|:...|.|..::.|.||.:::|...||.:...:.||.::.:|.:|.
Zfish   823 ETLLTENMVQSLLKLLPEQEQLNTLSEMKDEYEELAESEQFGVVISSVKRLKPRLTAILFKLQFE 887

  Fly  1129 LTINDLVPRITSVMEASREVARSRRLRKLLELVLALGNYMNRGAR-GNASGFRLASLNRLADTKS 1192
            ..:|::.|.:.:|..|..|:.:|....||||:.|.|||::|.|:| ..|.||.::.|.:|.||||
Zfish   888 EQVNNVKPDVVAVTAACEELRKSESFAKLLEITLLLGNFLNAGSRNAKAFGFSVSYLCKLRDTKS 952

  Fly  1193 SAAKGTTLLHYLVQVIERKFKDLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEFH 1257
            :..| .||||:|.:..:.::.:::...:::.||.:|||||...:.|.:..:...:..:.::||
Zfish   953 ADQK-QTLLHFLAETCQEQYPEVMTFPEELIHVEKASKVSAETLQKSLDQMGKQIKSLEKDIE-- 1014

  Fly  1258 RSSGPAQQGDRFLPVMREFHAQASVRFAELEDKFQDMKTRFDRAVRLFGEDGSVLQPDEFFGIFD 1322
            ....|....|:|:..|..|.:.|...|.:|:...::|:.:::...:.|..|...:.|:||||..:
Zfish  1015 TFPPPQSDKDKFVEKMTSFVSTARENFEKLQLLHENMEKQYEDLGKYFVFDPKKMTPEEFFGDLN 1079

  Fly  1323 SFLAAFAEARHDNESFRRRQEEEEKRAK---QEAELKKRTIERKNKTGLMTSVARNLGLKSGSSN 1384
            :|...|.:|..:|:. |:..||:.:|||   ::||.:|...:::..:|.:.::           |
Zfish  1080 NFRTMFQQAVKENQK-RKEAEEKLRRAKLAREKAEKEKEEKQKRINSGQIPNI-----------N 1132

  Fly  1385 GDPDSPAKGGDNKGEFDDLISALRTGDVFGEDMAKFKRSRKARVLNGGGSSTGHT---------- 1439
            .|       ||..|..|.|:.||::|       |.|:|.|..|.........||.
Zfish  1133 DD-------GDETGIMDGLLEALQSG-------AAFRRKRGPRPAANNRRGAGHAVTNLLAKELL 1183

  Fly  1440 ---SPPRHGSLQREESGRERERT 1459
               :||......|:::...:|.|
Zfish  1184 QEDAPPSATKKSRQDATDGKEST 1206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:283920	51/250 (20%)
		Drf_FH3	551..737	CDD:283917	53/188 (28%)
		FliJ	779..>875	CDD:280262	20/106 (19%)
		FH2	950..1328	CDD:280362	112/381 (29%)
LOC101886015	XP_021336758.1	Drf_GBD	81..267	CDD:310750	42/187 (22%)
		Drf_FH3	273..462	CDD:310747	57/206 (28%)
		SMC_N	<469..>563	CDD:330553	21/93 (23%)
		FH2	709..1086	CDD:280362	113/383 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010