DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAAM and LOC101733308

DIOPT Version :9

Sequence 1:	NP_001188522.1	Gene:	DAAM / 31075	FlyBaseID:	FBgn0025641	Length:	1463	Species:	Drosophila melanogaster
Sequence 2:	XP_004918788.3	Gene:	LOC101733308 / 101733308	-ID:	-	Length:	754	Species:	Xenopus tropicalis

Alignment Length:	788	Identity:	167/788 - (21%)
Similarity:	312/788 - (39%)	Gaps:	177/788 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   609 PGQENLEF---RLHLRYEFLMLGIQPVIDKLRTHENETLDRHLDFFEM--VRAEDEKEFARRFKE 668
            |.::...|   :...|::..:|.|....:.:...|..||.:...|.::  .:..|:.:|...| .
Frog    62 PSKQQYNFTVYKFRYRWQKRILQIDFYSEMIFNIEKGTLKKQFPFSQIKACKKTDDLKFVISF-Y 125

  Fly   669 EHVDTKSAGS-----------MFELLRR--KLSHSPAY--PHMLS--LLQHMLLLPYTGHCTEHW 716
            .|.|.:...:           |.::::|  :.|||.:|  .|..|  ||:.:|.|
Frog   126 GHQDYELEAACREDKESIMKIMNDIIQRNDQTSHSQSYAKKHAYSDVLLEGILEL---------- 180

  Fly   717 LLIDRVVQQIVLQVEQRPNSDLIVDPDDPEKQLKLAAESPVHDPDVAPLQIDVAKLVRLLVKEEQ 781
                           ..||||..|      |.|                 :.:.|...:....||
Frog   181 ---------------AEPNSDTWV------KNL-----------------VKMKKEELIFYSYEQ 207

  Fly   782 LTQARKRADELE-----------RENFDVQS---------RLAKKEQELDLRMQEKEDLETGLAR 826
            .|:..|....|.           ..:|.::|         .|.|..|:.:.|::|::|...
Frog   208 KTEPLKNTLTLSDCHVTPSPNGVSPSFTLKSGGHSYMFRIPLNKHTQDPENRIKERDDWVA---- 268

  Fly   827 MRERLEKESAQHSQAVQRAQTAEMRAEDLQHRLISEQQERARLERLVTEGSIPDDQKVAGLTGCN 891
               .|:|:.||..|....   .|....|..| |.:...|....:.|.....:....:....|...
Frog   269 ---LLQKQCAQSQQCPAH---QEEPPSDAGH-LTNNHTEPLLYQELHIYSQVKRGPRDCNETNIY 326

  Fly   892 GAVSPPPAPPMLKAIPPPPPPMAPSMMPPPPPPCPGAPPPP---PSMAQTMAPAPPKVDLPKKNV 953
            ..:|.....|..:.:.|....:.|...|.|||     ||||   ||:.:         |:.||.
Frog   327 NELSFRSTSPNKEVLSPSAGFLIPPSRPAPPP-----PPPPILFPSVQR---------DIIKKT- 376

  Fly   954 PQPTNPLKSFNWSKLPDAKLQGTVWSE-LDESKLYNNMELESIDKLFSAYQKNGVSATDGSYEDL 1017
                   |:|:|..:|:.|::.::||: ..:.|:.:...:     :|....::...|||.|.::|
Frog   377 -------KAFHWDVVPNDKIKHSMWSQAASDPKILDTQRI-----MFQFQTQDKPVATDMSLDNL 429

  Fly  1018 RVTGKAAKQKVLSVIDGRRAQNCTILLSKLKMSDMEI-SKAILSMDSNEQLQLDMVEQLLKFTPS 1081
            :     .:|.:|:|   :.|.|.:|:|....|...:: .|.::..:.:..|..:.:..|.::.|:
Frog   430 K-----NQQIILNV---KVAHNFSIVLKGFNMEPWQLKDKLLIIHERDGGLSDENLTNLRRYIPT 486

  Fly  1082 AEER----ALLDEHSEDIESLARADRFLYEISKIPHYEQRLKSLHYKKRFMLTINDLVPRITSVM 1142
            .:::    ||....||    |...|:|:.|:.|||....:|..|...:...:.:.|:.|.:...:
Frog   487 LKDKNTYLALKSPPSE----LHIVDQFMLEMCKIPDLGPKLDVLLAIREVPMYMKDIHPLLCHKI 547

  Fly  1143 EASREVARSRRLRKLLELVLALGNYMNRGA-RGNASGFRLASLNRLADTKSSAAKGTTLLHYLVQ 1206
            :|.:::.:|:...::|:.:||:||::|..| :.:|.||||:||.:::...|. .|..||.|.||:
Frog   548 QACQQLLKSQSFSQVLKYILAIGNFLNENAGKESAKGFRLSSLLKMSHLMSK-EKRFTLTHALVE 611

  Fly  1207 VIERKFKDLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIE----FHRS-SGPAQQG 1266
            .|..:..||.....::.........|:..:..::.:       .|:|:|    :.:: ....|:|
Frog   612 QILLQEPDLASFSQELTEFEAVPGASVKGLTAEVDV-------TAKELEKINQYRKTFKSKLQKG 669

  Fly  1267 ----DRFLP----VMREFHAQASVRFAELEDKFQDMKTRFDRAVRLFGEDGSVLQPDEFFGIFDS 1323
                .:||.    :::.:.||..    ||..|..::|..:...::.|||:.. ....|.||...|
Frog   670 AANETQFLKDLTNILKVYQAQQE----ELSKKSCELKKLYSEVLQKFGEEDD-QDSQELFGWVSS 729

  Fly  1324 FLAAFAEA 1331
            |:..|..|
Frog   730 FIKEFKNA 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:283920
		Drf_FH3	551..737	CDD:283917	28/149 (19%)
		FliJ	779..>875	CDD:280262	24/115 (21%)
		FH2	950..1328	CDD:280362	91/397 (23%)
LOC101733308	XP_004918788.3	PH	172..275	CDD:395117	27/157 (17%)
LOC101733308	XP_004918788.3	FH2	374..735	CDD:418645	91/398 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010